penisdoc.md
Urology research digest. Science journalism, not medical advice.
- Gene Defect Leaves Sperm Trapped in Cytoplasm2026-07-15
A single gene defect leaves mouse and human sperm wrapped in leftover cytoplasm, misshapen, and infertile
SPEM2 deficiency disrupts spermiation leading to oligoasthenoteratozoospermia and male infertility male infertility genetics spermatogenesis animal study semen quality
- Low T From Stress Isn't Broken Testicles2026-07-15
Military and athlete studies suggest stress-related low testosterone is often reversible brain signaling, not testicular failure
Stress-associated testosterone suppression: central adaptation or hypogonadism? testosterone hypogonadism narrative review stress exercise
- Skip Leg Day, Hurt Your Fertility?2026-07-11
A narrative review argues weak muscles and low testosterone track with worse sperm quality, but cites no new data of its own
Male fertility as an integral reflection of metabolic, endocrine, and musculoskeletal health male infertility narrative review testosterone exercise
- Clomiphene Matches TRT's Testosterone Boost, Not Libido2026-07-11
Clomiphene raised testosterone about as well as TRT gel in 1,512 men, but libido scores came out lower
Clomiphene citrate versus testosterone replacement therapy in male hypogonadism: a systematic review of literature and meta-analysis hypogonadism testosterone therapy male infertility meta-analysis
- Nanoparticle Packaging Makes an Antioxidant More Testicle-Protective2026-07-06
Chitosan-wrapped naringin protected rat testes from pesticide damage better than the plain compound did
Molecular insights into the protective role of nano-naringin in mancozeb-induced testicular damage and infertility animal study nanomedicine oxidative stress male infertility
- TRT and Heart Risk: Is a Gel Safer Than a Shot?2026-07-05
Low testosterone tracks with worse blood vessel markers, and TRT improves most of them, but gel vs. injection safety claims are still unproven
Circulating Markers of Cardiovascular Health in Hypogonadism Before and After Testosterone Therapy: Molecular Aspects and Formulation Comparison hypogonadism testosterone therapy cardiovascular disease vascular health biomarkers narrative review
- Healthy Obesity Barely Moves the ED Needle2026-07-03
In 3,767 men, metabolically unhealthy obesity roughly tripled ED odds, but obesity alone with no metabolic issues didn't
Association between metabolic obesity phenotypes and erectile dysfunction: Insights from a nationally cross-sectional study erectile dysfunction obesity metabolic syndrome cross-sectional
- Female Testosterone Therapy: Only 2 Trials Back Premenopausal Use2026-07-03
Postmenopausal testosterone therapy has 7 RCTs behind it, premenopausal use has just 2
Testosterone therapy for female sexual dysfunction: a systematic review of the literature demonstrating outcomes in premenopausal and postmenopausal women testosterone therapy women's health sexual dysfunction systematic review menopause
- The Fertility Add-On That Doesn't Add Up2026-07-01
ICSI showed no live birth edge over standard IVF in 1,438 couples without severe male infertility
Does Intracytoplasmic Sperm Injection Outperform Conventional In Vitro Fertilization in Couples Without Severe Male Factor Infertility? A Systematic Review and Meta-Analysis of Randomized Controlled Trials infertility male infertility evidence quality systematic review
- RF Device Boosts Sex Scores, But Blinding Is Shaky2026-07-01
Radiofrequency device beat sham for postmenopausal sexual function in a 62-woman trial, but effect sizes look implausibly large
Efficacy of nonablative radiofrequency on sexual function in postmenopausal women: a randomized clinical trial menopause women's health sexual dysfunction quality of life
- Testosterone After Prostate Cancer, Zero Recurrences2026-07-01
Testosterone restored sex drive in prostate cancer survivors, with zero recurrences in 136 men over 12 weeks
Testosterone Treatment in Prostate Cancer Survivors With Hypogonadism: A Randomized Clinical Trial hypogonadism testosterone therapy prostate cancer cancer survivors
- The Radiologist's Guide to a Broken Penile Implant2026-07
A single-author review argues MRI, not CT or ultrasound, is the best tool for spotting penile implant failures
Imaging of the Three-Piece Inflatable Penile Prosthesis penile prosthesis erectile dysfunction narrative review surgical outcomes
- OCD Linked to Female Arousal Problems, Not Male2026-06-30
A 13-study review finds OCD symptoms track with female desire and arousal problems, but the male sexual function data is a wash
The interplay between the obsessive-compulsive disorder and sexual function: a systematic review sexual dysfunction mental health systematic review women's health evidence quality
- Two-Thirds of Hypertensive African Men Report ED2026-06-30
Pooled data from 3,648 hypertensive African men found 65% report erectile dysfunction, but studies barely agree
Prevalence of erectile dysfunction and its associated factors among hypertensive men in Africa: a systematic review and meta-analysis erectile dysfunction hypertension meta-analysis epidemiology
- A Huge Effect Size Nobody Should Trust Yet2026-06-30
Counseling for MS-related sexual problems looks massively effective, but most trials are tiny, unregistered, and from one country
Effectiveness of non-pharmacological treatments for sexual difficulties in adults with multiple sclerosis: a systematic review and meta-analysis multiple sclerosis sexual dysfunction meta-analysis evidence quality
- A Gut Bug That Flags Kidney Stone Return2026-06-29
A Chinese prospective study found Escherichia-Shigella gut abundance, family history, and creatinine predicted stone recurrence with AUC 0.943 in validation.
Development and Validation of a Predictive Model for Calcium Oxalate Kidney Stone Recurrence Integrating Gut Microbiome and Clinical Features kidney stones gut microbiome biomarkers cohort study
- Two Standard Methods Get Penile Physics Backwards2026-06-29
Two common elastography methods gave physiologically reversed results in penile stiffness imaging; a filtering fix corrected them across all 6 patients
Reverberant Wavefield Characterization and Directional Filtering for Penile Vibro-Elastography: A Pilot Feasibility Study in Post-Prostatectomy Erectile Dysfunction erectile dysfunction surgical outcomes biomarkers prostate cancer
- High Blood Pressure Causes ED, Study Claims2026-06-26
Genetic data links hypertension to erectile dysfunction, but the paper never states the actual effect size
Bibliometric and Two-Sample Mendelian Randomization Analyses of the Causal Relationship Between Hypertension and Erectile Dysfunction hypertension erectile dysfunction bibliometrics genetics
- Lifelong Male Infertility Diagnosis Reverses in 1-in-102026-06-25
~10–15% of men with congenital hypogonadotropic hypogonadism spontaneously recover testosterone and fertility after stopping treatment
Reversible Congenital Hypogonadotropic Hypogonadism: Keys for Clinical Management hypogonadism male infertility genetics narrative review
- 82% of Young Cancer Survivors Report Sexual Dysfunction2026-06-25
82% of young adult cancer survivors reported at least mild sexual dysfunction; female survivors scored nearly twice as impaired as males
Appraisal of sexual functioning before and after cancer: insights from adolescent and young adult (AYA) cancer survivors and matched healthy controls. survivorship sexual dysfunction cross-sectional quality of life women's health cancer survivors
- 75% of Klinefelter Cases Go Undiagnosed2026-06-24
A review argues Klinefelter syndrome wrecks more than fertility, yet up to 75% of cases go undiagnosed
Klinefelter syndrome beyond hypogonadism: multisystem manifestations and a framework for clinical surveillance hypogonadism cardiovascular disease testosterone therapy narrative review
- Most Low Testosterone Is Just Obesity2026-06-23
JAMA review puts obesity-driven low T (2–8% prevalence) well ahead of true gonadal failure (<1%), with weight loss as first-line.
Adult Male Hypogonadism: A Review hypogonadism testosterone obesity testosterone therapy narrative review
- Meet the Immune Cells Guarding Your Sperm Supply2026-06-23
A review of mouse studies argues rogue immune cells in the testis may drive some male infertility
Testicular macrophages: core immune regulators and emerging therapeutic targets in spermatogenic dysfunction male infertility spermatogenesis immunology testicular disease animal study narrative review
- Shockwave Therapy Works, But Not How They Thought2026-06-23
Radial shockwave therapy improved erectile function in 44% of 48 men with vasculogenic ED, but left cavernosal oxidative stress markers unchanged
Evaluation of Cavernosal Oxidative Biomarkers Following Radial Li-ESWT in Vasculogenic Erectile Dysfunction erectile dysfunction oxidative stress vascular health biomarkers
- Robotic Testis Cancer Surgery: One Country, One Hospital2026-06-22
A 20-year literature map of robotic RPLND finds 93 total papers, nearly 40% from the US, with Johns Hopkins alone matching the output of every other institution.
Research trends and collaboration patterns in robotic retroperitoneal lymph node dissection for testicular cancer testicular cancer robotics surgical outcomes bibliometrics
- Pesticide Wrecks Rat Sperm; Nanoparticles Help2026-06-22
Niosome-encapsulated l-carnitine and quercetin partially reversed atrazine-induced sperm damage in rats — in groups of 5 animals each
Niosomal l-carnitine and quercetin improve sperm quality and testicular function in atrazine-induced reproductive toxicity in rats animal study oxidative stress male infertility environmental exposure nanomedicine semen quality
- 100% Success Rate Raises More Questions Than It Answers2026-06-20
Couple-based behavioral therapy resolved psychogenic ED in all 66 unconsummated marriages — a suspiciously perfect result with no control group
Treatment of Unconsummated Marriage in Psychogenic Erectile Dysfunction among Iranian Couples erectile dysfunction sexual dysfunction mental health relationship health couples therapy
- 1 in 4 NOA Men Become Fathers via TESE2026-06-20
Only 40 of 168 men with severe infertility fathered a child via TESE-ICSI, taking a median 19.5 months
Cumulative live birth rates following testicular sperm extraction in non-obstructive male infertility. male infertility retrospective cohort pregnancy surgical outcomes
- The Testicular Tumor That Fools Every Blood Test2026-06-19
A 21-year-old's painless testicular mass turned out to be a tumor type so rare it accounts for under 1% of testicular neoplasms — and all standard tumor markers came back normal.
Primary Testicular Neuroendocrine Tumor: Diagnostic Challenges and WHO 2022 Classification Insights case report testicular cancer testicular disease pathology biomarkers
- New Ultrasound Spots Fertility Treatment Response Early2026-06-18
A super-resolution ultrasound scan detected testicular treatment response before blood hormone tests did
Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility hypogonadism male infertility biomarkers case-control study
- Two Hormones Beat One for Azoospermic Men2026-06-16
74% of azoospermic men produced sperm on hormone therapy; combination outperformed monotherapy 78% vs 33%
Therapeutic Benefits of Gonadotropins in Male Hypogonadotropic Hypogonadism hypogonadism male infertility spermatogenesis retrospective cohort pregnancy
- One Testosterone Test Isn't Enough for ED2026-06-16
Lab review argues most ED workups over-order hormones and under-order glucose and lipids
High-value laboratory testing in erectile dysfunction, reduced sexual desire, and suspected hypogonadism: analytical pitfalls and selective biomarker use erectile dysfunction hypogonadism testosterone biomarkers narrative review
- Five Cell Death Routes Killing Sperm2026-06-16
Narrative review maps five regulated cell death pathways — apoptosis, autophagy, pyroptosis, ferroptosis, efferocytosis — as drivers of spermatogenic failure
Targeting Programmed Cell Death in Male Infertility: Pathogenic Mechanisms and Therapeutic Strategies male infertility spermatogenesis autophagy oxidative stress narrative review inflammation
- Kidney Stone Nanotech: All Lab, No Clinic2026-06-16
A narrative review of nanomaterial strategies for kidney stones — none have reached clinical use, and the authors admit it
The Application of Nanomaterials in Kidney Stone Disease: Emerging Strategies for Early Diagnosis, Targeted Therapy, and Prevention kidney stones nanomedicine narrative review oxidative stress
- Could a Blood Test Replace Testicular Biopsy?2026-06-15
A 2026 narrative review maps the landscape of non-invasive biomarkers for azoospermia diagnosis, covering small RNAs, proteomics, genetic markers, and imaging
Research Progress on the Pathogenesis and Diagnostic Biomarkers of Azoospermia male infertility biomarkers genetics genomics spermatogenesis narrative review
- Routine Kidney Stone Stents: More Pain, No Benefit2026-06-13
32 RCTs and 3,572 patients find routine double-J stenting after ureteroscopy increases morbidity without improving stone clearance
Does Omitting a Ureteral Stent Affect the Outcomes of Uncomplicated Ureteroscopy for Ureteral and Kidney Stones in Adults? Results from a Systematic Review and Meta-Analysis of Comparative Randomized Trials by the EAU Endourology Section kidney stones surgical outcomes systematic review meta-analysis quality of life
- The Iodine Kidney Stone Paper That Can't Agree With Itself2026-06-12
NHANES data on 9,443 adults hints at a kidney stone risk bump at mid-range iodine levels — but the numbers in the abstract don't match the results table
The Association Between Dietary Intake of Iodine and Kidney Stones: A Study of the National Health and Nutrition Examination Survey 2007-2018 kidney stones cross-sectional epidemiology dietary exposure
- Joint Hypermobility and Vulvodynia: 100% — With a Catch2026-06-12
In 44 clinic patients with hEDS, every single one had vestibulodynia — but they were all already there for pelvic pain
Characterizing Sexual Dysfunction in Females with Hypermobile Ehlers Danlos Syndrome or Hypermobility Spectrum Disorder and Genito-Pelvic Pain cross-sectional sexual dysfunction pelvic floor women's health
- Vaccine Maker Tallies Peru's HPV Cancer Burden2026-06-12
Five of seven authors work for Merck; their study finds 208 HPV-attributable male cancer deaths in Peru (2015–2019), penile cancer driving most hospitalizations
Burden of HPV-Associated Cancers in Peruvian Men: Evidence from National Health Data HPV penile cancer epidemiology health services
- Early Sex Linked to ED Risk—But Just Barely2026-06-12
Genetic proxies for later first sex associated with ~37% lower ED odds in mixed-sex cohorts; male-only results lose significance once confounders are stripped out.
Bayesian Mendelian Randomization Reveals a Protective Effect of Later Age at First Sexual Intercourse Against Erectile Dysfunction erectile dysfunction genetics epidemiology sexual dysfunction
- Why Won't Testicular Cancer Respond to Immunotherapy?2026-06-11
Checkpoint inhibitors largely fail in testicular germ cell tumors despite PD-L1 expression and tumor-infiltrating lymphocytes — a review argues miRNAs may explain why
MicroRNAs and Immunotherapy in Testicular Germ Cell Tumors: Opportunities and Challenges for Modulation of the Immune Microenvironment testicular cancer immunology biomarkers narrative review
- Melatonin Reverses Shift-Work-Like Erectile Dysfunction — In Rats2026-06-11
Melatonin partly restored erectile function in rats with disrupted light cycles by blocking a cell-death pathway
Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis erectile dysfunction animal study oxidative stress circadian rhythm
- Vitamins Topped Every Other Lifestyle Factor in IVF2026-06-10
Of 501 couples undergoing IVF, the only factor linked to pregnancy when both partners were assessed together was taking vitamins, minerals, and trace elements
Occupational and Lifestyle Factors of Male and Female Infertility Patients: Do They Impact ART Success? infertility male infertility occupational exposure pregnancy cohort study
- Hair Drug Users Take ED Pills 8 Months Earlier2026-06-08
Men on finasteride 1mg for hair loss were prescribed PDE5 inhibitors at 13.6% vs 10.5% — and 238 days sooner
The Urologic Impact of Long-Term Finasteride 1-mg Use for Androgenic Alopecia: A Matched-Cohort Database Analysis erectile dysfunction BPH prostate cancer retrospective cohort pharmacovigilance
- **Analysis failed:**2026-06-06
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- Sildenafil Wins — But Viatris Paid For It2026-06-05
Network meta-analysis of 83 RCTs finds sildenafil 100mg has the highest odds ratio (9.06) vs placebo — funded by sildenafil's manufacturer
A Comparative Evaluation of On-Demand Phosphodiesterase-5 Inhibitor Efficacy in Erectile Dysfunction Treatment: A Systematic Review and Network Meta-Analysis of Double-Blind, Placebo-Controlled, Randomized Trials erectile dysfunction systematic review meta-analysis pharmacovigilance
- The Gene That Kills Erections in Hypertensive Rats2026-06-05
In hypertensive rats, Ephx2 overexpression in penile endothelium suppresses the AKT/eNOS pathway; silencing it or giving icariin restored measurable erectile function
Suppression of Ephx2 in Endothelial Cells of Penile Cavernous Tissue Improves SHR Erectile Function animal study erectile dysfunction hypertension vascular health traditional chinese medicine genetics
- Penile Implant Restores Function—For One Man2026-06-05
Single-patient case report argues for earlier prosthesis referral after radical prostatectomy, with no data beyond one outcome
Restoring Sexual Health and Relationship Quality Through Penile Prosthesis Implantation case report erectile dysfunction penile prosthesis prostate cancer survivorship patient satisfaction
- Shockwave, PRP, Stem Cells: Still Not Proven2026-06-05
ISSM-commissioned review of 36 studies finds mixed, inconsistent evidence for all restorative ED therapies, with 78% of trials failing to report clinically meaningful outcomes
Systematic Review on the Safety and Effectiveness of Restorative Therapies for Erectile Dysfunction erectile dysfunction systematic review evidence quality stem cells
- Chinese Herb Mix Repairs Cadmium-Damaged Sperm — In Mice2026-06-04
A 7-herb TCM formula reversed cadmium-induced testicular damage in mice, improving sperm DNA fragmentation and hormone levels — no human data exists
A mechanistic study on the repair of cadmium-induced male infertility using Yishen Tongluo formula based on network toxicology and experimental validation male infertility animal study oxidative stress traditional chinese medicine DNA fragmentation environmental exposure
- Kidney Transplant Fixes Hormones, Not Sexual Function2026-06-04
65% of women with advanced CKD had sexual dysfunction; hormones improved after transplant but sexual dysfunction persisted
Sex Hormones and Sexual Health in Chronic Kidney Disease Before and After Kidney Transplantation sexual dysfunction women's health longitudinal study chronic kidney disease
- Bile Pigment Spotted Where Kidney Stones Form2026-06-04
Red-orange crystals in 1.1% of Randall's plaque stones were identified as calcium bilirubinate — a bile pigment — possibly linked to liver disease.
Calcium Bilirubinate at the Randall's Plaque-Kidney Stone Interface: First Description kidney stones pathology retrospective cohort case report
- Your Father's Chemical Exposure May Shape Your Health2026-06-03
Review links six ubiquitous EDC classes to sperm damage and transgenerational harm — paternal occupational exposure tied to low birth weight and congenital heart disease in offspring
Endocrine Disruption and Male Fertility environmental exposure epigenetics male infertility semen quality oxidative stress infertility
- How Radiologists Spot Penile Emergencies2026-06-02
A picture-based radiology primer on penile fractures, priapism, Peyronie's disease and tumors
Decoding penile pathology and imaging techniques. Peyronie's disease priapism penile cancer narrative review
- Two Cheap Drugs Beat One for Diabetic Testis Damage — In Mice2026-06-02
Combination metformin + vitamin C outperformed either drug alone on sperm viability and Johnsen scores in streptozotocin-diabetic mice (n=6/group)
Protective Effects of Metformin and Vitamin C on Diabetes-Induced Testicular Dysfunction animal study diabetes male infertility oxidative stress spermatogenesis
- Most Priapism Cases Arrive Too Late to Save Erections2026-06-01
39% of priapism patients developed ED at 30 days — most arrived with erections lasting over 24 hours
Ischemic Priapism: Evaluation in a Third-Level Hospital in Mexico erectile dysfunction cross-sectional surgical outcomes priapism health services
- **Analysis failed:**2026-06-01
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- Male Infertility's Default Drug May Be Wrong for Most2026-06-01
Opinion review argues clomiphene and aromatase inhibitors are empirically prescribed without endocrine phenotyping — and proposes gonadotropins instead
From Tablets to Targeted Therapy: The APHRODITE Era in Male Infertility male infertility hypogonadism spermatogenesis narrative review evidence quality
- Pediatric Penile Emergencies: Screen for Abuse2026-06-01
Narrative review covering ED diagnosis and management of pediatric penile conditions, from paraphimosis to strangulation injury, with abuse screening emphasized
Management of pediatric penile problems in the emergency department. pediatric urology narrative review health services emergency medicine
- Two Men Failed IVF Until Doctors Checked Their DNA2026-06
Two novel PLCZ1 frameshift mutations caused near-total IVF failure; adding assisted oocyte activation pushed fertilization rates to 73–80%
Clinical Features and PLCZ1 Gene Variants in Two Cases of Male Infertility: A Case Series and Literature Review genetics genomics male infertility case report
- Folate Doesn't Move the Needle on Kidney Stones2026-05-29
Folate intake and circulating folate markers had no significant association with kidney stone disease in 9,208 US adults after adjusting for confounders.
Association Between Dietary and Circulating Folate Markers and Kidney Stones in American Adults: A Cross-Sectional NHANES Analysis kidney stones cross-sectional epidemiology biomarkers
- When Testicular Cancer Attacks the Brain2026-05-29
Anti-KLHL11 encephalitis is rare, lethal in 1 of 3 patients within a year, and linked to seminoma in nearly a third of cases.
Clinical Manifestations, Tumor Associations, and Long-Term Outcomes of Anti-KLHL11 Encephalitis testicular cancer immunology paraneoplastic syndrome retrospective cohort
- Synbiotics Cut Oxalate — And Nothing Else2026-05-29
Synbiotic capsules reduced urinary oxalate significantly (P=.001) vs placebo over 12 weeks, but left all other stone-risk markers unchanged.
Effects of Synbiotic Supplementation on Blood and Urinary Concentrations of Factors Related to Kidney Stone Formation in Overweight or Obese Patients with Hyperoxaluria: A Randomized Controlled Trial kidney stones gut microbiome obesity oxidative stress
- Insulin Pumps May Protect Female Sexual Function2026-05-28
About 1 in 3 women with T1DM has sexual dysfunction — twice the rate of healthy controls, and higher than T2DM
Female Sexual Dysfunction in Type 1 Diabetes: A Systematic Review and Meta-Analysis diabetes sexual dysfunction women's health meta-analysis systematic review
- Radiation Snaps the Hinge That Makes Sperm Swim2026-05-27
Synchrotron imaging in irradiated mice reveals the sperm annulus — a structural ring — as the primary fracture point after ionizing radiation exposure
Annulus Fracture Underlies Radiation-Induced Sperm Dysfunction Revealed by Multimodal Nano-Imaging animal study male infertility spermatogenesis environmental exposure semen quality
- High Uric Acid Triples Kidney Stone Risk in Men2026-05-26
In 31,198 Korean adults, men with the highest uric acid levels had 3.5× the odds of kidney stones — women showed no such link
Association Between Asymptomatic Hyperuricemia and Kidney Stones kidney stones cross-sectional epidemiology metabolic syndrome
- Can Varicocele Inflammation Reach the Penis?2026-05-25
A narrative review proposes that varicocele-driven systemic inflammation may impair erectile function — but the clinical evidence is thin
Advances in Immune-Inflammatory Interactions Within the Testicular-Penile Microenvironment of Varicocele Patients varicocele erectile dysfunction inflammation narrative review oxidative stress spermatogenesis immunology male infertility
- Who Trained Your Stone Doc Changes Your Surgery2026-05-24
300 endourologists worldwide agree on watching small stones; for large ones, treatment varies by where and when you trained
Shifting Paradigms in Stone Disease: How Geography, Training, and Technology Shape Endourologic Practice Worldwide kidney stones health services surgical outcomes cross-sectional
- Oxidative Lipid Damage Markers: A New IVF Yardstick?2026-05-23
A narrative review argues F2-isoprostanes and isofurans could be stable, reliable markers of reproductive oxidative damage — but admits the evidence base is thin
Isoprostanes and Isofurans in Infertility and Assisted Reproduction: What Do We Know So Far? oxidative stress infertility male infertility biomarkers narrative review semen quality
- Lupus Sexual Dysfunction: Body Image Is a Red Herring2026-05-23
In 68 Mexican women with lupus, overall body image did not predict sexual dysfunction — partner status, age, and self-esteem did
Body image and sexual function in women with systemic lupus erythematosus: a cross-sectional study sexual dysfunction cross-sectional women's health mental health quality of life
- Weight Loss Surgery Improved Sperm Quality — No Pregnancies Followed2026-05-23
43 obese infertile men saw testosterone rise and semen motility improve after bariatric surgery — but zero pregnancies in 12 months
The Influence of Different Bariatric Surgeries on Male Sex Hormones and Semen Parameters Among Infertile Obese Male Patients: An Observational Study male infertility obesity testosterone semen quality surgical outcomes
- Their Own Herbal Formula Fixed Sperm — in Mice2026-05-22
Mouse study: a team's proprietary herbal decoction improved sperm count and motility after drug-induced damage, via PI3K/Akt and MAPK pathways
Chinese Medicine Sheng Jing Decoction Alleviates Oligoasthenospermia by Modulating PI3K/Akt and MAPK Signaling Pathways animal study male infertility traditional chinese medicine spermatogenesis oxidative stress
- Two Supplements Blunt Chemo's Testicular Damage — In Rats2026-05-21
Melatonin and apigenin each partially reversed paclitaxel-induced testicular damage in rats, raising Johnsen scores from 5 back to ~8 out of 9
Comparative Protective Effects of Melatonin and Apigenin Against Paclitaxel-Induced Testicular Injury in Rats: Oxidative Stress, DNA Damage, Apoptosis, and NF-κB Signaling animal study oxidative stress spermatogenesis testicular disease male infertility
- Brain Immune Cells Gatekeep Fertility Hormones2026-05-21
Brain immune cells (microglia) use RANK signaling to control GnRH neurons — and rare RANK variants show up in 564 hypogonadism patients
Microglia Rank Signaling Regulates GnRH Neuronal Function and the Hypothalamic-Pituitary-Gonadal Axis hypogonadism infertility genetics animal study
- Measuring Female Sexual Dysfunction With ED Pills2026-05-20
SNRIs carried the highest SD risk (aOR 1.75) among antidepressants; women's data is nearly unmeasurable by design
Patterns and Treatment of Sexual Dysfunction in Major Depressive Disorder: A Cohort and Case-Control Study in Sweden antidepressants sexual dysfunction cohort study mental health epidemiology
- Nerve-Repair Bubbles Restore Erections in Rats2026-05-20
Rat study: injecting lipid-packed cellular vesicles near injured cavernous nerves boosted ATP, cut apoptosis, and raised intracavernous pressure.
Microvesicles Rewire Nerve Energy to Restore Erections in Rats animal study erectile dysfunction nanomedicine oxidative stress
- Plastic in Every Kidney Stone Tested2026-05-19
Microplastics found in 100% of kidney stone samples tested, median 12.89 μg/g, with six distinct polymer types identified
Multimodal Detection of Microplastics in Human Kidney Stones and Multi-Omics Exploration of Renal Cell Metaflammation kidney stones environmental exposure oxidative stress inflammation
- New Gene Found Behind Structurally Broken Sperm2026-05-19
Knockout mice lacking DNAI4 are completely infertile with shattered sperm flagella, pointing to a candidate gene for the ~40% of human MMAF cases still unexplained.
DNAI4 is Required for Flagellum Assembly and Male Fertility in Mice animal study male infertility genetics spermatogenesis
- 1 in 5 Online Testosterone Clinics Invent Cardiovascular Benefits2026-05-19
253 testosterone clinic websites worldwide: 1 in 4 promote off-guideline treatments, 1 in 5 falsely claim cardiovascular benefits
Discordance Between Online Information and Male Hypogonadism Clinical Guidelines: A Global Multilingual Content Analysis hypogonadism testosterone therapy health services evidence quality
- Brain Tumors Trigger Both Early and Late Puberty2026-05-19
In 60 kids with intracranial germ cell tumors, 45% developed a puberty disorder—too early, too late, or both in sequence
Pubertal Dysfunctions in Intracranial Germ Cell Tumors hypogonadism pediatric urology retrospective cohort survivorship
- Lab Mice Can't Fake 30 Years of Kidney Stones2026-05-18
Most kidney stone animal models induce acute disease; human idiopathic CaOx stones develop over decades — a mismatch this review maps out.
Animal Models for Calcium Oxalate Kidney Stone Research kidney stones animal study narrative review evidence quality
- The Testicular Tumors That Fool Even Pathologists2026-05-17
10% of testicular sex cord stromal tumors follow an aggressive, therapy-resistant course that can rapidly become fatal
Testicular Sex Cord Stromal Tumors testicular cancer testicular disease pathology narrative review
- Gut Bacteria May Hurt Sperm. The Evidence Is Thin.2026-05-16
A plausible gut-testis axis linking dysbiosis to poor sperm quality — authors themselves admit few human studies back it up
Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions gut microbiome male infertility spermatogenesis narrative review testosterone inflammation
- Testosterone Therapy May Raise Fracture Risk2026-05-16
TRAVERSE trial found higher fracture rates in men randomized to testosterone — a result the review calls "unexpected"
Testosterone and Bone Health in Men testosterone testosterone therapy hypogonadism evidence quality
- Curable Cancer That Still Kills Young Men2026-05-14
Testicular cancer is among the most curable metastatic solid tumors — but the poor-risk subset still carries significant mortality in young men
How to Optimize Treatment for Patients With Poor-Risk Testicular Cancer testicular cancer narrative review surgical outcomes survivorship
- CML Drug Hits Developing Testes Hardest2026-05-14
Imatinib damages testes via c-KIT/PDGFR inhibition; neonatal exposure carries high irreversibility risk, adult exposure is more forgiving
A Scoping Review of Imatinib-Induced Testicular Toxicity and Male Fertility Impairment male infertility spermatogenesis scoping review pharmacovigilance pediatric urology
- One Editorial, No New Data on Varicocele2026-05-12
A leading infertility surgeon's editorial preview of a themed issue, containing no original data of its own
Varicocele: new perspectives on an old problem varicocele male infertility narrative review testosterone
- Immune War in the Testis — Mostly Mouse Data2026-05-12
A review proposes that a shared immune-inflammatory cascade disrupts sperm production — then admits most evidence comes from animals, not men.
Immunological Mechanisms and Precision Stratification in Male Infertility immunology male infertility inflammation oxidative stress narrative review biomarkers spermatogenesis
- Birch Tree Compound Fights Post-Surgery ED — In Rats2026-05-12
Betulinic acid reduced penile smooth muscle apoptosis in nerve-injured rats, but this is a 5-rats-per-group rodent study with no funding disclosure
Betulinic Acid Ameliorates Cavernous Nerve Injury-Induced Erectile Dysfunction Through Nrf2/HO-1 Pathway Activation and Inhibition of Mitochondrial Damage-Dependent Corpus Cavernosum Smooth Muscle Cells Apoptosis animal study erectile dysfunction oxidative stress surgical outcomes
- Online Sex Therapy: 8 Studies, Mostly Cancer Patients2026-05-11
A meta-analysis of 8 studies and 961 participants — mostly cancer patients — found online CBT and psychoeducation measurably improved sexual function
Online Interventions for the Treatment of Sexual Dysfunctions: Systematic Review and Meta-Analysis sexual dysfunction systematic review meta-analysis mental health quality of life
- BPH Drugs Tank Sex Drive. Does Rezum?2026-05-11
Rezum patients gained sexual desire and erectile function at 1 year; every drug regimen caused significant declines across multiple sexual domains
Sexual Function Outcomes of 5-Year Rezum Treatment vs. Drug Therapy for BPH BPH erectile dysfunction sexual dysfunction surgical outcomes
- Exercise Moves the Needle on Prostate Cancer Sex Life2026-05-11
Exercise improved sexual activity (SMD 0.38) and sexual function (SMD 0.32) in prostate cancer patients across 10 RCTs of 558 men
Effects of Exercise on Sexual Activity and Sexual Dysfunction in Patients with Prostate Cancer: A Systematic Review and Meta-Analysis exercise prostate cancer sexual dysfunction systematic review meta-analysis quality of life
- Yes, Exercise Helps ED. The Effect Is Modest.2026-05-11
16 RCTs, 1,477 men: lifestyle interventions improved IIEF scores by 2.35 points — statistically significant, clinically borderline.
Efficacy of Lifestyle Interventions in Treating Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials erectile dysfunction systematic review meta-analysis vascular health exercise
- Penile Implant Drains: Trend Toward Worse, Not Better2026-05-11
Drain use after three-piece penile implant surgery showed no benefit — hematoma rates trended slightly higher in the drain group
Does a 24-h Closed-Suction Drain Reduce Infection and Hematoma After Inflatable Penile Prosthesis Surgery? A Comparative Study penile prosthesis surgical outcomes erectile dysfunction retrospective cohort
- Young Men With ED Almost Never See a Psychiatrist2026-05-11
In a cohort of young men with ED and a diagnosed mental health condition, only 6.2% ever had a psychiatry appointment.
Evaluating Mental Health Risk and Psychiatric Care Access in 18–40 Year Old Men with Erectile Dysfunction erectile dysfunction mental health health services retrospective cohort
- Modified Hypospadias Fix: Better Flow, Same Risk2026-05-11
Modified TIPU improved urinary flow rates and penile straightness scores at 2 years, with no increase in complication rates (n=183)
Efficacy of Modified Tubularized Incised Plate Urethroplasty for Hypospadias hypospadias pediatric urology surgical outcomes
- Hypospadias Men Care About Looks, Not Meatus Location2026-05-11
78 of 501 patients responded: those who did reported good overall satisfaction, driven more by appearance than urinary function (r = .60)
Long-Term Sex Life After Hypospadias Repair: Appearance Beats Anatomy hypospadias surgical outcomes patient satisfaction pediatric urology sexual dysfunction quality of life
- New ED Drug: Higher Dose, Same Effect, More Side Effects2026-05-09
Phase 2 RCT of 255 men finds simenafil (5–20 mg) improves IIEF-EF scores ~9 points over placebo, but 20 mg hits 62% adverse event rate with no clear efficacy advantage over 5 mg
Efficacy and Safety of Simenafil in Men with Erectile Dysfunction: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Parallel-Group, Phase 2 Trial erectile dysfunction vascular health sexual dysfunction
- Diabetes Wrecks Sex Lives, Doctors Rarely Ask2026-05-09
A single-author narrative review argues South Asian diabetes clinics routinely skip sexual health screening entirely
Sexual dysfunction in patients with Type 2 diabetes: A South Asian perspective diabetes sexual dysfunction erectile dysfunction women's health narrative review
- Exercise Boosts Female Sexual Function—Evidence Weak2026-05-09
Exercise interventions produced a mean 5.31-point FSFI improvement vs. controls (15 studies), but evidence certainty is rated low.
Systematic Review and Meta-Analysis on the Beneficial Effect of Exercise on Sexual Dysfunction in Women sexual dysfunction systematic review meta-analysis women's health pelvic floor evidence quality
- Plastic Chemicals May Rewrite Fertility Across Generations2026-05-08
A narrative review argues BPA harms male fertility via gut dysbiosis and epigenetic marks — but admits the transgenerational evidence is provisional at best
Transgenerational Exposure to Plastics-Derived Endocrine-Disrupting Bisphenol A and Its Analogs on Male Infertility: Impact of Gut Dysbiosis and Epigenetic Regulation environmental exposure epigenetics male infertility narrative review spermatogenesis gut microbiome
- Diabetes Breaks Both Sperm and Memory — Here's How2026-05-08
A narrative review proposes shared neuroendocrine-immune pathways linking diabetic infertility and cognitive decline — no new data, theory only
The relationships between diabetic male infertility, diabetic cognitive impairment, and the neuroendocrine-immune network: A review diabetes male infertility narrative review spermatogenesis neurodegenerative diseases
- Frailty Score Predicts ED—But Only Moderately2026-05-08
Frail men had 22% higher odds of ED vs. non-frail men in a 1,372-person NHANES analysis; predictive accuracy was moderate (AUC 0.662)
Association Between Frailty Index and Erectile Dysfunction: A Cross-Sectional Study Using NHANES 2001 to 2004 Data erectile dysfunction cross-sectional epidemiology biomarkers
- Female Sexual Dysfunction: Still Playing Catch-Up2026-05-07
Narrative review from Duke maps all 4 DSM-5 subtypes of female sexual dysfunction and finds evidence for multiple treatments—but measurement tools remain unstandardized
Female Sexual Dysfunction: Current Models and Treatment Options sexual dysfunction women's health narrative review pelvic floor
- One Y Chromosome Deletion Beats Two for Sperm Retrieval2026-05-07
AZFc deletions yield sperm retrieval in 58.85% of azoospermic men; complete AZFa/b deletions are essentially futile for TESE.
Y Chromosome and Male Fertility: The AZF Genes and Their Deletion genetics male infertility spermatogenesis genomics
- Your Kidney Doctor Has No Idea You're Drinking That2026-05-07
~20% of kidney stone patients use cranberry extract or ACV; 87% believe them safe, almost none heard about them from a physician
Patient Perceptions of Dietary Supplement Use and Kidney Stone Disease kidney stones cross-sectional health services evidence quality
- Testicular Cancer Gets Its First Moderate-Risk Gene2026-05-06
CHEK2 becomes the first moderate-penetrance predisposition gene identified for testicular germ cell tumors, alongside growing ties to inherited cancer syndromes
Recent Advances in Genetic Predisposition to Primary Testicular Tumors testicular cancer genetics genomics narrative review
- Lab-Grown Mini-Testes Make Hormones — Sperm Still Elusive2026-05-06
Testicular organoids sustain testosterone and inhibin B production for up to 12 weeks in culture, but complete spermatogenesis remains out of reach
Generation and Utility of Endocrine Functional Testicular Organoids stem cells spermatogenesis male infertility narrative review testicular disease
- Semen Inflammation Signals Sperm DNA Damage — With Caveats2026-05-06
High sperm DNA fragmentation correlated with elevated NLRP3, caspase-1, IL-1β, and IL-18 — but the protein data came from only 5 men per group
Inflammasome-Related Markers and Long Non-Coding RNAs in Seminal Plasma: Associations with Sperm DNA Fragmentation and Male Infertility male infertility DNA fragmentation inflammation biomarkers epigenetics oxidative stress
- Viral Orchitis Treatments Still Largely Inadequate2026-05-05
This narrative review covers how viruses like HIV and mumps damage testicular function—and admits current treatments fall short
Viral Orchitis and Male Infertility: A Comprehensive Review of Pathogenic Mechanisms and Outcomes male infertility orchitis spermatogenesis inflammation narrative review immunology
- Half of Cancer Survivors Can't Sleep. Nobody's Asking.2026-05-05
Commentary argues sleep disorders go unscreened in testicular cancer follow-up, citing a meta-analysis finding 60.7% prevalence of sleep disturbance across cancer survivors
Integrating the Relevance of Sleep into Testicular-Cancer Survivorship Care testicular cancer survivorship systematic review meta-analysis
- Breast Cancer Therapy's Unspoken Sexual Toll2026-05-04
An integrative review of 43 studies found sexual dysfunction in 51–93% of breast cancer patients on endocrine therapy, yet providers routinely stay silent about it.
Sexual Health Among Patients With Breast Cancer Undergoing Endocrine Therapy: An Integrative Review sexual dysfunction women's health survivorship systematic review
- Every Man After a Heart Attack Had ED2026-05-04
All 400 post-MI men had ED, and its severity was the single strongest predictor of quality of life after a heart attack.
Erectile Dysfunction and Quality of Life After Myocardial Infarction: A Cross-Sectional Study with Routine Point-of-Care Penile Doppler Ultrasonography erectile dysfunction cardiovascular disease cross-sectional quality of life vascular health
- Lupus Roughly Doubles the Odds of Female Sexual Dysfunction2026-05-04
58.8% of lupus patients screen positive for FSD — 2.6x healthy controls, though extreme heterogeneity muddies the estimate
Prevalence of Female Sexual Dysfunction Among Women with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis sexual dysfunction women's health immunology systematic review meta-analysis epidemiology
- Prostate Patients Fear Bowel Damage More Than Erectile Dysfunction2026-05-04
In 88 men with intermediate-risk prostate cancer, bowel symptoms ranked as the #1 factor to avoid — above erectile dysfunction — while urinary symptoms didn't significantly sway choices at all.
Patient Preferences for Treatment of Intermediate-risk Prostate Cancer: A Discrete Choice Experiment prostate cancer patient satisfaction health services erectile dysfunction quality of life
- The Psych Treatment That Works Isn't CBT2026-05-01
Overall effect looks strong (SMD=1.37), but CBT and mindfulness had near-zero effect — counseling and education drove the headline.
Psychological Treatments for Sexual Concerns in Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-Analysis menopause women's health sexual dysfunction meta-analysis systematic review mental health
- Inside Infertile Sperm: The Missing Power Switch2026-05
In sperm from oligoasthenospermic men, ATP synthase subunits dropped significantly while cytochrome c oxidase rose — in just 17 men
High-Resolution Imaging Reveals Mitochondrial Protein Imbalance in Sperm of Oligoasthenospermic Men male infertility semen quality biomarkers oxidative stress
- A Third Way Sperm Cells Die: Ferroptosis2026-05
Review maps three oxidative stress-driven cell death pathways in testicular tissue, spotlighting ferroptosis as an understudied mechanism
Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis male infertility oxidative stress spermatogenesis narrative review iron metabolism autophagy
- Melatonin for Low Testosterone: Interesting Theory, No Trials2026-05
Chinese TCM researchers propose melatonin could restore endogenous testosterone by repairing aging Leydig cells — supported by animal data and zero LOH clinical trials
From "Passive Supplementation" to "Active Repair": Melatonin Reshapes the Treatment Paradigm for Late-Onset Hypogonadism by Targeting Leydig Cell Senescence hypogonadism testosterone oxidative stress narrative review traditional chinese medicine
- When Should Teen Varicoceles Get Surgery?2026-04-30
One children's hospital's playbook for deciding which teens with varicocele need surgery
Adolescent varicocele: a surgical conundrum varicocele pediatric urology male infertility narrative review surgical outcomes
- Shockwave and PRP for ED? Still Experimental, Review Concludes2026-04-30
Narrative review synthesizes the full ED treatment ladder — prosthetics top 95% satisfaction; shockwave and PRP remain experimental.
Erectile Dysfunction: A Comprehensive Review of Pathophysiology, Diagnosis and Contemporary Management erectile dysfunction narrative review penile prosthesis sexual dysfunction evidence quality
- Your Genes, Not Your Diet, May Drive Low Phosphate2026-04-30
Narrative review argues that low phosphate in stone formers is driven by genetic defects in kidney transporters, not diet—and that supplementation may cut recurrence.
Hypophosphatemia in Kidney Stone Formers kidney stones genetics narrative review biomarkers
- Can Metformin Treat Male Infertility?2026-04-29
Review argues AMPK—an energy-sensing enzyme disrupted by obesity and diabetes—could be a druggable target for male infertility
Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies male infertility metabolic syndrome spermatogenesis narrative review oxidative stress testosterone
- Robotic Surgery's Edge Over Laparoscopy? Basically Nothing2026-04-27
44 studies, 6,121 patients: robotic rectal surgery shows no consistent advantage over laparoscopy for urinary or sexual function
Comparison of Functional Outcomes Between Robotic and Laparoscopic Surgery in Rectal Cancer Patients: Systematic Review and Meta-Analysis surgical outcomes meta-analysis sexual dysfunction robotics
- Five Pregnancy Factors Predict Hypospadias Risk2026-04-27
Five obstetric factors — gestational hypertension, abnormal placenta, and preterm birth among them — predicted hypospadias with AUC 0.857 in temporal validation
Risk Factor Analysis and Nomogram Predictive Model Construction for Neonatal Hypospadias: A Large-Scale Multicenter Study in East China hypospadias pediatric urology pregnancy biomarkers
- New Penile Cancer Guidelines Still Mostly Guesswork2026-04-27
Updated international penile cancer guidelines lean heavily on retrospective data and expert consensus, not trials
European Association of Urology and American Society of Clinical Oncology Guidelines on Penile Cancer: A Summary of the 2026 Guidelines Update penile cancer evidence quality survivorship quality of life
- Silent TB Hides Behind Infertility in 1 in 4 Women2026-04-27
Genital TB found in ~26% of infertile women, with most showing no respiratory symptoms — only infertility
TB Manifests as Infertility: A Systematic Review and Meta-Analysis infertility systematic review meta-analysis women's health tuberculosis
- Sperm Create the Toxins That Destroy Them2026-04-25
Oxidative stress causes at least one-third of male infertility, and sperm generate the damaging reactive oxygen species themselves
Molecular Advances in Male Infertility and Fertility: Importance of Redox Regulation and Oxidative Stress male infertility oxidative stress sperm capacitation narrative review
- Hypospadias Hints at Hidden Testicular Problems2026-04-22
113 Danish infants with hypospadias showed reduced Sertoli and Leydig cell markers during minipuberty, regardless of defect severity
Reproductive Hormones During Minipuberty Suggest Subtle Testicular Impairments in Boys With Hypospadias hypospadias pediatric urology testosterone biomarkers
- One Gene Variant Ties Infertility, Ataxia, and Brain Cell Death2026-04-22
RNF216 loss-of-function variants kill cells via runaway autophagy — found in 2 of 1,476 HH patients
RNF216 Variants Found in Patients With Dementia, Hypogonadotropic Hypogonadism, and Severe Ataxia Deregulate Autophagy genetics hypogonadism neurodegenerative diseases autophagy
- Skipping Testosterone Therapy Raises Death Risk2026-04-22
In 408 men with pituitary tumors followed 8 years, TRT showed no increase in heart attack or stroke risk — but untreated low T was tied to higher mortality
Secondary Hypogonadism and Effects of Testosterone Replacement Therapy on Cardiovascular Events hypogonadism testosterone therapy cardiovascular disease cohort study
- Dyslipidemia and ED: Plausible but Not Proven2026-04-22
A review maps five pathways linking dyslipidemia to ED, then concedes direct evidence for all five is limited
Mechanisms of Dyslipidemia-Induced Erectile Dysfunction: A Narrative Review erectile dysfunction narrative review cardiovascular disease vascular health metabolic syndrome oxidative stress
- Severe Sleep Apnea Suppresses Testosterone in Obese Men2026-04-22
62% of severely obese male inpatients had low testosterone; severe sleep apnea was an independent predictor, and CPAP raised T after 3 months in 14 men
The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity hypogonadism obesity testosterone cross-sectional
- Whose Infertility Hurts Whom More?2026-04-21
Female-factor infertility lowered male partners' wellbeing scores; male-factor infertility had no detectable effect on female partners
Male- and Female-Factor Infertility and Partners' Quality of Life During ART infertility male infertility cross-sectional quality of life
- Chemo Wrecks Testes — A Gut Molecule Probably Won't Fix It2026-04-19
Doxorubicin scrambles testicular metabolism in mice; a gut-derived molecule reduced cell-dish damage, but the human genetic signal didn't survive correction for multiple comparisons
Metabolomics and Exploratory Mendelian Randomization Identify Indole-3-Propionic Acid Associated with Doxorubicin-Induced Testicular Injury animal study male infertility oxidative stress biomarkers
- ED as an Early Warning Sign for Heart Damage2026-04-18
Review paper argues ED can show up 2-5 years before heart disease, or within months on certain cancer drugs
Erectile dysfunction as an early biomarker of cardiovascular toxicity: Mechanisms and clinical implications erectile dysfunction cardiovascular disease biomarkers narrative review
- Genetic Cause Found in Only 1 in 4 Female IHH Cases2026-04-18
Only 4 of 17 sequenced female IHH patients (23.5%) had an identifiable pathogenic variant; the majority remain genetically undiagnosed
Genetic variants analysis of 17 female patients with idiopathic hypogonadotropic hypogonadism genetics genomics hypogonadism women's health infertility
- 1 in 8 Diabetic Men Has ED, 660,000-Man Study Finds2026-04-17
659,501 men in Catalonia: ED prevalence was 12.6% in T2DM vs 8.3% in non-diabetic men — a 1.5-fold difference peaking at ages 55–64.
Prevalence and Clinical Characteristics of Erectile Dysfunction Among Men with Type 2 Diabetes in Primary Care: A Cross-Sectional Study in Catalonia diabetes erectile dysfunction cross-sectional epidemiology cardiovascular disease health services
- 31 Studies, Still No Clear Answer2026-04-17
31 studies on UI and sexual function reviewed; inconsistent findings prevent any conclusions about what actually works
Strategies to Improve Sexual Health in Women with Urinary Incontinence: A Scoping Review urinary incontinence sexual dysfunction women's health pelvic floor scoping review
- Genetics Breaks the Prostatitis-ED Link2026-04-17
Genetic analysis of FinnGen data found no causal link between prostatitis and ED in either direction (OR=1.132, P=.199)
No Causal Effect Between Prostatitis and Erectile Dysfunction: Insights from a 2-Sample Bidirectional Mendelian Randomization Study erectile dysfunction genetics inflammation genomics
- TCM Sperm Pill: 56 Animal Studies, 8 Human Trials2026-04-16
A PRISMA-screened evidence map finds mechanistic plausibility but only 8 clinical trials — most evidence is animal data
Multi-component, multi-target actions of Wuzi Yanzong Pill in male infertility: An evidence map linking clinical signals to mechanistic networks. male infertility traditional chinese medicine spermatogenesis oxidative stress evidence quality
- Testicular Cancer's Suicide Risk Lasts a Decade2026-04-15
Men with testicular cancer had 31% higher suicide mortality than the general population; risk doubled in year one and persisted for 10 years
Persistent Suicide Risk in Survivors of Testicular Cancer: A Population-Based Cohort Study testicular cancer survivorship cohort study epidemiology
- Testosterone-Tipped Nanoparticles Find the Testes in Mice2026-04-15
Nanoparticles carrying green tea extract (EGCG) and zinc reduced testicular inflammation and preserved sperm structure in a mouse orchitis model
Testosterone-Modified Liposomes Loaded with the Zn-Polyphenol Complex for Treatment of Male Infertility animal study male infertility inflammation oxidative stress spermatogenesis
- Treating Rare Tumors Quietly Wrecks Fertility2026-04-15
Review finds chemotherapy has proven fertility harm in NET patients, while somatostatin analogues appear relatively safe — but data on sexual function is nearly absent
Reproductive and Sexual Sequelae of Neuroendocrine Tumour Therapies sexual dysfunction infertility survivorship systematic review
- Beyond Overheating: Varicocele's Multi-Front War on Sperm2026-04-15
Narrative review maps varicocele's damage chain: dilated veins trigger heat, oxidative damage, inflammation, and immune attacks that collectively wreck sperm
Testicular Microenvironment Disruption in Varicocele: Mechanisms and Implications for Spermatogenesis varicocele male infertility oxidative stress spermatogenesis narrative review
- AI Stone Predictions Work—Until You Pool Them2026-04-15
Only 5 retrospective cohorts met inclusion criteria; heterogeneity was so extreme the authors declared their own pooled estimates "clinically uninterpretable"
Can AI and Predictive Models Accurately Predict Stone-Free Status? A Systematic Review and Meta-Analysis artificial intelligence kidney stones systematic review meta-analysis
- This paper is out of scope for penisdoc.md.2026-04-15
This paper is out of scope for penisdoc.md.
- Testicular Calcifications Are Only Scary With Baggage2026-04-15
65 studies reviewed: isolated testicular microlithiasis carries minimal cancer risk on its own — the company it keeps is what matters
From Incidentaloma to Actionable Insight: A Clinical-Molecular-Imaging Framework for Risk-Stratified Management of Testicular Microlithiasis testicular cancer testicular disease scoping review biomarkers screening
- The Gene That Breaks Sperm—But Not Eggs2026-04-15
Mice lacking the RNA-binding protein LARP1 produce sperm with defective flagella, malformed heads, and poor motility — females are unaffected
Deficiency of LARP1 Impairs Spermatogenesis and Leads to Male Subfertility in Mice animal study male infertility spermatogenesis genetics
- AI Designs an Iron Nanoparticle to Treat Diabetic ED2026-04-14
An ML-guided iron nanozyme reduced oxidative stress in diabetic rat corpus cavernosum, restoring erectile function in an animal model
Design of Single-Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single-Cell RNA Sequencing and Machine Learning erectile dysfunction diabetes nanomedicine oxidative stress artificial intelligence animal study
- Vitamin D Improves Sperm, Not Pregnancies2026-04-13
Vitamin D boosted sperm motility by 6.96% and testosterone slightly, but had no measurable effect on pregnancy or live birth rates (n=1,168)
Vitamin D supplementation in infertile men: a systematic review and meta-analysis of effects on semen quality and endocrine function male infertility semen quality testosterone meta-analysis systematic review
- The 100-Year-Old Prolapse Surgery That Still Wins2026-04-13
Old uterus-sparing prolapse surgery beat newer techniques on recurrence and cost, but pregnancy data is thin
The Manchester procedure: A systematic review of recurrence, perioperative measures, and financial cost, and a scoping review of sexual dysfunction, gynecologic cancer, and obstetric outcomes surgical outcomes systematic review scoping review women's health
- 328 Stones, One Conflict of Interest2026-04-11
96% intraoperative stone clearance in a 22-min median op time—one author is a paid consultant for the device maker.
A Feasibility Study on a Digital Disposable Semirigid Nephroscope for Suction Mini-Percutaneous Nephrolithotripsy kidney stones surgical outcomes
- Pelvic Muscle Tears After Birth: Sex Impact Unclear2026-04-11
9 studies, 1,623 women: only 2 of 9 found a link between levator ani avulsion and postpartum sexual dysfunction
The Relationship Between Levator Ani Integrity and Postpartum Sexual Dysfunction: A Systematic Review systematic review pelvic floor sexual dysfunction women's health pregnancy
- A 12-Fold ED Risk Gap Hidden in Your DNA2026-04-11
A deep learning model trained on 810 genetic variants predicted post-radiation ED with AUC 0.75 and an 11.8-fold odds gap between risk groups.
Deep Learning on Genome-Wide Association Studies to Predict the Patient-Specific Risk of Radiation-Induced Erectile Dysfunction artificial intelligence erectile dysfunction genetics genomics prostate cancer
- Malnutrition Splits Non-Seminoma Survival: 16% vs 97%2026-04-10
Non-seminoma patients with depleted metabolic profiles had 16.1% five-year survival vs 97.4% in those with preserved profiles
Metabolic Profile and Skeletal Muscle as Predictors of Survival in Testicular Germ Cell Tumors testicular cancer biomarkers survivorship cohort study
- Sling Surgery Lifts Sexual Function at 6 Months, Then Fades2026-04-09
MUS surgery improved PISQ-12 scores by 4.49 points at 6 months, but the gains largely reversed by 12 months and didn't recover
Impact of Mid-Urethral Sling Surgery on Sexual Function in Women with Stress Urinary Incontinence: A Meta-Analysis of Randomized Controlled Trials meta-analysis systematic review sexual dysfunction pelvic floor surgical outcomes women's health urinary incontinence
- Depression Nearly Doubles Penile Implant Infection Risk2026-04-09
Men with anxiety or depression had 79% higher 90-day infection rates after penile implant surgery; antidepressants didn't close the gap.
What is the impact of anxiety and depression on penile prosthesis outcomes? A population-level assessment. penile prosthesis surgical outcomes antidepressants health services
- More Dilation, Less Surgery During Penile Implants2026-04-09
Upgrading to larger dilators during IPP surgery in Peyronie's disease significantly reduced residual intraoperative curvature and the need for additional corrective steps (P < .01)
Extended Corporal Dilation Decreases Need for Adjuvant Maneuvers During Penile Implant Placement in Peyronie's Disease penile prosthesis surgical outcomes Peyronie's disease erectile dysfunction
- Newer Blood Pressure Drugs May Not Cause ED After All2026-04-09
A narrative review claims newer antihypertensives are ED-neutral or better, but cites no new data of its own
Erectile dysfunction and antihypertensive therapy: A critical reappraisal erectile dysfunction hypertension cardiovascular disease narrative review evidence quality
- Reddit Fills the Gap Pelvic Pain Doctors Left2026-04-09
201 Reddit posts reveal that pelvic pain patients turn online because medicine consistently fails to diagnose or validate their conditions
Seeking Answers and Finding Support: A Qualitative Analysis of Sexual and Pelvic Pain Online Communities on Reddit pelvic floor sexual dysfunction women's health health services
- New Obesity Hurts Erections More Than Chronic Obesity2026-04-09
Brazilian men who became newly obese had 2.46× the odds of persistent ED vs. stable healthy-weight men; those already obese had 1.73×
Longitudinal Associations Between Changes in Body Mass Index and Erectile Dysfunction erectile dysfunction obesity cohort study vascular health
- Sensation Loss Predicts Penile Implant Satisfaction2026-04-09
After IPP surgery in 159 men, sensory loss predicted 17.7-point lower satisfaction scores; penoscrotal vs. infrapubic approach made no difference
Patient-Reported Penile Sensory Loss, Not Surgical Approach, Is Associated with Sexual Satisfaction After Inflatable Penile Prosthesis Implantation penile prosthesis erectile dysfunction surgical outcomes sexual dysfunction
- After Anal Cancer Radiation, Sexual Damage Persists for Years2026-04-09
32 studies found vaginal dryness in up to 98% of women after anal cancer radiotherapy — and it often doesn't resolve
Prevalence, Risk Factors, and Interventions for Female Sexual Dysfunction After Radiotherapy for Anal Cancer: A Systematic Review systematic review sexual dysfunction survivorship women's health pelvic floor
- Eye Autoimmunity to ED: Pure Speculation2026-04-08
A hypothesis paper proposes that autoimmune retinopathy might damage circadian-regulating retinal cells and thereby impair testosterone and nitric oxide signaling — no data included
A Hypothetical Circadian–Endocrine Pathway Linking Melanopsin-Expressing ipRGC Dysfunction in Autoimmune Retinopathy to Sexual Dysfunction erectile dysfunction sexual dysfunction immunology biomarkers
- Anti-Aging Peptide Fights Post-Surgery ED — in Rats2026-04-08
A Klotho-derived peptide reduced penile fibrosis and preserved erectile function in rats after cavernous nerve injury — no human data yet
Klotho-Derived Peptide Preserves Erectile Function by Limiting Fibrosis, Oxidative Stress, and Apoptosis of Penile Smooth Muscle Cells in Cavernous Nerve Injured-Rats Through Suppression of the TGF-β1/TGF-β Type II Receptor Signaling animal study erectile dysfunction oxidative stress prostate cancer
- Six Providers, Five Sessions, No Patients Tested Yet2026-04-08
Sexual dysfunction affects 20–50% of childhood cancer survivors; six oncology providers spent 5 co-design sessions building a screening prototype — none of it tested on patients yet
Provider-Engaged Development of a Sexual Dysfunction Screening Approach for Adolescents and Young Adult Childhood Cancer Survivors: Iterative Co-Design Study screening sexual dysfunction survivorship health services
- Gallstones Double Your Kidney Stone Risk2026-04-08
People with gallstones had 80% higher odds of developing kidney stones in a 121,000-person Taiwanese cohort
Gallstone Disease Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study kidney stones cohort study cross-sectional metabolic syndrome
- Central Asia's Male Infertility Problem Is Getting Worse2026-04-06
Male infertility prevalence rose in 4 of 5 Central Asian countries over 32 years; incidence climbed in all five
Long-Term Epidemiological Trends and Regional Disparities in Male Infertility in Central Asia (1991-2023) male infertility health services epidemiology environmental exposure
- Fasting Hormone Reverses SSRI Sexual Side Effects — In Rats2026-04-05
Asprosin injected directly into rat brains reversed paroxetine-induced erectile dysfunction, sperm loss, and testicular damage across all 5 endpoints measured
Asprosin Infusion Modulates Central Circuits to Rescue Selective Serotonin Reuptake Inhibitor-Induced Male Dysfunction antidepressants sexual dysfunction animal study semen quality
- Female Fetal Ligaments Aren't Hormonally Passive2026-04-05
In first-trimester human fetuses, caudal genital ligaments in both sexes express receptors for androgens, estrogens, and INSL3 — the "passive female default" model doesn't hold in humans
Receptivity of the Human Male and Female Fetal Caudal Genital Ligament to Gonadal Hormones cryptorchidism pediatric urology environmental exposure pregnancy genomics
- Burned-Out Testis After Chemo Rarely Hides Viable Tumor2026-04-03
After chemo for metastatic testicular cancer, no viable invasive tumor was found in men whose post-chemo ultrasound showed normal, burned-out, or sub-centimeter residual findings.
Postchemotherapy Orchiectomy in Metastatic Testicular Germ Cell Tumors: Pathologic Findings and Predictors of Residual Viable Disease testicular cancer pathology surgical outcomes retrospective cohort
- Sexual Medicine Has a Pleasure Problem2026-04-02
An editorial argues clinical sexual medicine neglects justice, rights, and pleasure — proposing a shift from fixing dysfunction to enabling well-being
Sexual Health Framing Sexual Medicine: Toward a More Humanistic Framework sexual dysfunction evidence quality women's health health services
- Stroke, Parkinson's, MS All Disrupt Bladder2026-04-02
Review maps how neural damage from cortex to ganglia produces distinct bladder and sexual dysfunction across 10+ neurological conditions
Urogenital Dysfunction in Neurological Diseases Parkinson's disease multiple sclerosis sexual dysfunction erectile dysfunction
- Could Infertility Predict Brain Disease? Too Soon to Tell2026-04-02
13-study systematic review finds preliminary mechanistic overlap between male infertility and neurodegeneration — no prospective evidence yet
Male Infertility and Neurodegenerative Diseases: A Systematic Review of Associations and Molecular Mechanisms systematic review male infertility neurodegenerative diseases oxidative stress biomarkers
- Web Therapy Helps ED—If Men Stick With It2026-04-02
21 studies found online CBT improved erectile function; ED remission rates were 20–30%, but fewer than 60% of participants stayed engaged
Internet-Based CBT and Online Counseling for Male Sexual Dysfunction: Systematic Review erectile dysfunction sexual dysfunction evidence quality
- Shockwave Beats Kegels in Diabetic ED, but Both Help2026-04-02
Adding either Li-ESWT or home pelvic floor training to sildenafil improved penile blood flow in 90 diabetic men; shockwave led by 10 cm/sec
Low-intensity shockwave therapy and pelvic floor muscle training each mitigate erectile dysfunction in men with diabetes: a randomised controlled trial erectile dysfunction pelvic floor vascular health diabetes
- Pharma Authors Write Fictional Stories, Call It Evidence2026-04-02
Two of four authors work for Viatris — a PDE5i manufacturer — yet COI is listed as "not listed"
Narrative-Based Sexual Medicine: Clinical Vignettes and PDE5 Inhibitor Management in Real-World ED erectile dysfunction evidence quality pharmacovigilance
- Your Antidepressant Has an 80% Sexual Side Effect Rate2026-04-01
Antidepressants cause sexual dysfunction in 25–80% of patients; antipsychotics in 16–60% — and most psychiatrists aren't asking
Psychiatric Disorders, Psychopharmacology and Sexual Dysfunction (ICSM 2024) antidepressants antipsychotics sexual dysfunction evidence quality
- Adding Testosterone Cuts Drug Dose, Not Sperm Rates2026-04-01
Triple therapy (hCG + FSH + testosterone) cut the median hCG dose needed by 17% but didn't significantly improve spermatogenesis rates in 45 CHH men
Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial hypogonadism spermatogenesis testosterone infertility
- Robot Fixes Floppy Ureteroscope Tip by 70%2026-04
A foldable bedside robot corrected ureteroscope tip bending error by 69.64% using a Bouc-Wen hysteresis model, validated in kidney phantoms and live animals.
Optimization Design and Bending Hysteresis Compensation of a Flexible Ureteroscopy Robot kidney stones surgical outcomes animal study robotics
- Cancer Clinics Are Dropping the Ball on Sexual Health2026-04
Sexual dysfunction is common across cancer types but rarely addressed in oncology care, per this narrative review — no numbers provided
Oncosexology: A Narrative Review on Sexual Health and Quality of Life in Cancer Patients sexual dysfunction survivorship narrative review women's health
- A Chinese Herbal Formula Targets Iron Cell Death — in Rats2026-04
TCM formula SFZYD reduced ferroptosis markers and improved erectile function in diabetic rats via the Nrf2/HO-1/GPX4 pathway — no human data
Mechanism of Shaofu Zhuyu Decoction in Improving Diabetes Mellitus Erectile Dysfunction Inhibition of Ferroptosis Based on Network Pharmacology and Experimental Validation diabetes erectile dysfunction traditional chinese medicine oxidative stress animal study
- Mesh Clinic Patients: Pain Gets Treated, Psych Distress Doesn't2026-04
74 women with mesh complications waited a median 185 days to see a specialist — and only 13.5% were referred to psychology despite high distress scores
A Retrospective Cohort Study Investigating the Clinical Care Pathway for Patients at a Pelvic Mesh Complications Clinic in a Western Australian Tertiary Hospital pelvic floor urinary incontinence women's health health services cohort study surgical outcomes
- Clear Guidelines Aren't Enough to Close the Rural Gap2026-03-31
Rural U.S. patients with early-stage kidney and prostate cancer were up to 26% less likely to receive guideline-concordant care than urban patients
Rural-Urban Variation in Guideline-Concordant Management of Early-Stage Kidney, Prostate, and Testicular Cancer in the United States (2010–2022) kidney cancer prostate cancer testicular cancer health services epidemiology surgical outcomes retrospective cohort
- Three Mouse Studies Don't Make a Therapy2026-03-31
A systematic review of exactly 3 mouse studies concludes fat-cell secretions partially regenerate chemotherapy-damaged testes — in rodents
Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Testicular Regeneration Following Chemically Induced Injury: A Review of Preclinical Studies male infertility stem cells animal study spermatogenesis
- Dog Tumor Marker Study Oversells Its Findings2026-03-31
87% of canine testicular seminomas expressed ezrin; higher expression correlated with the more invasive diffuse subtype (n=23)
Histomorphological Features and Ezrin Expression in Testicular Seminomas in Dogs: An Association with Potential Prognostic Value animal study testicular cancer pathology biomarkers
- A Mouse "Space Sperm" Study Finds a Fertility Protein2026-03-31
Mouse and cell study ties a mitochondrial peptide to sperm cell survival under simulated microgravity stress
Mitochondrial-Derived Peptide MOTS-c Targets SLC7A11 to Preserve Spermatogenesis by Suppressing Ferroptosis male infertility spermatogenesis oxidative stress animal study biomarkers
- Primary Care Penile Cancer Evidence: Coming Soon2026-03-30
A scoping review protocol — no findings yet — registering plans to map what evidence exists on these cancers in primary care
Strategies for Prevention, Early Detection and Management of Penile and Testicular Cancer in Primary Healthcare: Scoping Review Protocol penile cancer testicular cancer screening health services evidence quality
- Shockwave Therapy for ED: Short-Term Gains Fall Below the Meaningful Threshold2026-03-30
Cochrane review of 21 RCTs finds LiSWT may improve erectile function, but the short-term effect (MD 3.89 points) falls below the 4-point minimal clinically important difference — and all evidence is low certainty.
Low-intensity shockwave therapy for erectile dysfunction: An abridged Cochrane review erectile dysfunction systematic review meta-analysis evidence quality
- What's That on the X-Ray? A Urological Device Guide2026-03-27
Radiology review catalogues imaging appearances of penile implants, incontinence devices, cosmetic augmentations, and BPH hardware
Imaging Review of Male Genitourinary Devices and Augmentations penile prosthesis erectile dysfunction BPH urinary incontinence
- Four Blood Ratios, Kidney Stones, Mixed Signals2026-03-27
Four composite blood ratios tied to kidney stone prevalence in 27K Americans — but one of the four didn't hold up under scrutiny
Association Between Novel Indicators for Inflammation and Metabolism and Kidney Stones: A Cross-Sectional Analysis of NHANES 2007-2018 kidney stones inflammation biomarkers cross-sectional metabolic syndrome
- Infant Hormone Window Predicts Adult Fertility2026-03-26
Hormone levels at 1–3 months of life predict adult reproductive capacity and can flag hypogonadism before symptoms appear
Clinical Implications of Minipuberty pediatric urology hypogonadism biomarkers infertility
- Weight Loss Surgery Raises Testosterone — But Not the Free Kind2026-03-25
21 studies, 695 men: bariatric surgery improved IIEF-5 scores by 6.45 points and raised total testosterone, but free testosterone didn't move
The impact of bariatric surgery on male sexual function: a systematic review and meta-analysis obesity erectile dysfunction testosterone meta-analysis systematic review surgical outcomes
- Plant Compounds in Nanopackages Won't Fix ED Yet2026-03-24
Chemical engineering duo reviews plant-derived compounds delivered via nanoparticles for ED — heavy on preclinical data, light on clinical evidence
Phytochemical-Based Nanomedicine as a Promising Therapeutic Strategy for Erectile Dysfunction erectile dysfunction narrative review oxidative stress nanomedicine
- Every Common Kidney Stone Fix Has Weak Evidence2026-03-24
31-study review finds "low" strength-of-evidence for nearly every kidney stone prevention strategy, and zero data on surveillance imaging
Prevention of Recurrent Nephrolithiasis in Adults and Children: A Systematic Review kidney stones systematic review evidence quality pediatric urology
- Female Sexual Dysfunction: Still Going Unasked2026-03-24
A PA-focused clinical review covering FSD classification, risk factors, and treatments — no original data, no reported effect sizes
Female Sexual Dysfunction: Screening, Diagnosis, and Management sexual dysfunction women's health evidence quality screening
- Sperm's Molecular On-Switch — And How to Flip It2026-03-23
A narrative review maps the cAMP signaling cascade that triggers sperm capacitation — and flags it as a dual target for infertility treatment and non-hormonal male contraception
Mechanistic Insights into Sperm cAMP Signaling: Relevance for Male Infertility and Contraceptive Development male infertility sperm capacitation contraception oxidative stress
- Too Many Gene Copies Wreck Yak Hybrid Sperm2026-03-21
Yak Y chromosomes carry 2–4× more active sperm-related gene copies than cattle; researchers propose this mismatch explains complete hybrid male sterility
Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility male infertility spermatogenesis genomics animal study
- A Body Measurement Tracks Hypospadias Severity2026-03-21
Boys with hypospadias have shorter anogenital distance (SMD −1.24), with the gap widening as severity increases across 6,905 infants
Association Between Anogenital Distance and Hypospadias: A Systematic Review and Meta-Analysis hypospadias meta-analysis pediatric urology biomarkers environmental exposure
- China's Math on Male HPV Vaccination Is Clear2026-03-20
Modeling 22 strategies, 20 cleared China's cost-effectiveness bar; vaccinating 14-year-olds with a 4-valent vaccine won
Economic Evaluation of 22 HPV Vaccination Strategies to Minimize the Risk of Penile, Anal, and Oropharyngeal Cancers in Chinese Males: A Markov Model Analysis penile cancer health services immunology evidence quality
- New Drug Saves Mice From Fatal Kidney Disease2026-03-20
In mice bred to die of kidney failure by 15 weeks, a daily pill restored normal survival and stopped stone formation entirely
N-propargylglycine restores survival by preventing calcium oxalate stone formation, tubular injury, and kidney dysfunction in a lethal mouse model of primary hyperoxaluria type 2 kidney stones animal study genetics chronic kidney disease
- After Prostate Surgery, Literacy Predicts Who Actually Follows Through2026-03-20
Men with low health literacy were 71% less likely to maintain ≥80% rehab adherence after prostatectomy, per a Chinese single-center study of 1,615.
Health Literacy Correlates, Barriers, and Adherence in Post-Prostatectomy Sexual Rehabilitation: Cross-Sectional Findings from China prostate cancer sexual dysfunction cross-sectional health services survivorship
- Heat Kills Sperm. Can L-Citrulline Help? Ask a Pig2026-03-20
A narrative review of mostly animal data argues L-citrulline may protect sperm from heat damage via nitric oxide pathways — human evidence is thin
Heat Stress-Mediated Oxidative Damage in Male Germ Cells: Potential Protective Effects of L-Citrulline oxidative stress male infertility spermatogenesis animal study
- One Gene Deletion Kills All Sperm Maturation in Mice2026-03-20
Knocking out a single gene in mice triggers complete male infertility by blocking the histone-to-protamine swap that compacts sperm DNA
PRAMEL12 orchestrates spermiogenesis to ensure male fertility in mice animal study male infertility spermatogenesis genetics epigenetics
- Ginger Improves Sperm in Obese Rats — Humans TBD2026-03-20
Ginger and fenofibrate each reversed obesity-induced sperm and hormone deficits in rats — no human data exists
Effect of Ginger Extract and/or Fenofibrate on the Associated Infertility of Experimentally Induced Obese Wistar Albino Male Rats animal study obesity male infertility oxidative stress spermatogenesis testosterone
- One Blood Test Stands Out — But Should It?2026-03-19
In 198 Ghanaian ART patients, only serum chloride differed between pregnancy and non-pregnancy groups — a marginal gap within normal range
Male Factors Associated With Success Following Assisted Reproduction Technology Among Infertile Couples in Ghana male infertility semen quality cross-sectional biomarkers pregnancy
- Immunotherapy Shows Early Pulse in Rare Penile Cancer2026-03-19
First prospective trial of perioperative chemoimmunotherapy in locally advanced PSCC reports 53% response rate in 17 evaluable patients
Neoadjuvant and/or Adjuvant Immune Checkpoint Inhibitors Combined with Chemotherapy for Locally Advanced Resectable Penile Squamous Cell Carcinoma penile cancer immunology surgical outcomes cohort study
- The Testicular Tumor Hiding Behind Wrong Diagnoses2026-03-19
A review of an ultra-rare testicular malignancy, defined by EWSR1::ATF1 gene fusions, that has been routinely misclassified as other tumor types
Inflammatory and Nested Testicular Sex Cord Tumors: Clinical and Molecular Characterization testicular cancer genetics pathology biomarkers
- Male Fertility Prevention: Everything but the Numbers2026-03-18
Narrative review maps primary-to-tertiary prevention in male reproductive health — broad scope, no original data, no quantified effect sizes
Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review male infertility biomarkers infertility screening evidence quality
- Years Playing, Not Injury Severity, Predicts Bladder Control2026-03-18
In 69 paralyzed rugby players, years of sport participation predicted bladder control better than injury classification did
Urinary Symptoms and Sexual Dysfunction in National Level Wheelchair Rugby Male Athletes With Spinal Cord Injury sexual dysfunction erectile dysfunction cross-sectional spinal cord injury
- Vaginal Surgical Access Rarely Damages Sex Life2026-03-18
Across 30 studies and 2,488 women, transvaginal specimen extraction showed low rates of postoperative dyspareunia and no clinically meaningful decline in sexual function scores.
Dyspareunia and Sexual Dysfunction After Transvaginal Specimen Extraction — A Systematic Review surgical outcomes sexual dysfunction women's health systematic review
- FSH, Not Just Testosterone, May Drive Muscle Loss2026-03-17
Men with Klinefelter syndrome had significantly less lean mass than Kallmann men (ALMI 7.28 vs 8.37 kg/m²), implicating FSH
Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study hypogonadism testosterone therapy genetics biomarkers
- Stone History Doesn't Always Bar Kidney Donation2026-03-17
CT imaging detects Randall's plaques as false positives; true stone prevalence in donor candidates is 2–8%, half the general population rate.
Evaluation of Nephrolithiasis and Its Risk Factors in Living Kidney Donor Candidates kidney stones narrative review screening health services
- 75,000 Exams to Find One Testicular Cancer2026-03-17
Screening 300,793 adolescents caught 4 testicular cancers in 6 months — and 86% of all cases were stage I anyway
Screening of Adolescents for Testicular Cancer — A Nationwide Retrospective Cohort Study screening testicular cancer cohort study pediatric urology
- Most CHH Cases Have No Single Gene to Blame2026-03-17
In 88 Japanese CHH patients, only 39% had a confirmed pathogenic variant; the rest showed hallmarks of multi-gene inheritance
Comprehensive Molecular Studies in 88 Japanese Patients With Congenital Hypogonadotropic Hypogonadism genetics hypogonadism male infertility genomics
- ACE Inhibitors Beat Beta-Blockers for Female Sexual Function2026-03-17
ACEIs/ARBs improved all sexual function domains in hypertensive women; beta-blockers helped less, especially in uncontrolled hypertension (n=125, 3 months)
Sexual Function Among Hypertensive Females Receiving Beta-Blockers or ACEI/ARB and Thiazides: A Prospective Randomized Controlled Study sexual dysfunction cardiovascular disease women's health vascular health
- PE, Anxiety, and SSRIs: One Broken System2026-03-17
A 2026 narrative review maps how serotonin and BDNF link premature ejaculation to comorbid anxiety and depression — and makes a pitch for TCM adjuncts
Role of 5-HT and BDNF in Premature Ejaculation With Anxiety or Depression sexual dysfunction antidepressants traditional chinese medicine biomarkers
- When the Testes Lose Their Immune Shield2026-03-17
A narrative review estimates up to 15% of male infertility stems from immune dysregulation at the blood-testis barrier
Testicular Immune Privilege Revisited: When Protection Fails male infertility immunology narrative review antisperm antibodies spermatogenesis infertility
- Sperm's Chemical Entourage Signals the Uterus2026-03-16
Review argues seminal cytokines don't just carry sperm — they actively shape uterine receptivity and embryo implantation
Seminal Fluid Cytokines in Reproductive Health and Fertility of Men male infertility immunology semen quality inflammation narrative review
- AI Will Fix Male Infertility (Trust Us)2026-03-16
A solo computer scientist argues LLMs could transform male infertility research — with zero data to show for it
Future directions in infertility research: the role of generative AI and large language models. male infertility infertility genetics epigenetics
- Combat Didn't Raise Cancer Risk. Infantry Did.2026-03-15
Infantry soldiers had twice the adjusted testicular cancer risk of other Army occupations — but combat deployment showed no association
Factors Associated With Testicular Cancer Risk Among New American Military Recruits During Wartime testicular cancer environmental exposure health services survivorship
- The Cilia Gene Running the Sperm Factory2026-03-15
Knocking out a cilia gene in fish collapses the testicular niche — sperm motility fails and Sertoli cells die off before sperm do
NPHP4 Deficiency Disrupts Testicular Homeostasis and Impairs Male Fertility in Medaka (*Oryzias latipes*) animal study male infertility spermatogenesis genetics
- Planet-Friendly Diet Cuts Kidney Stone Risk 19%2026-03-14
Eating closer to the EAT-Lancet planetary health diet linked to 19% lower kidney stone incidence; genetics barely changed the math
Adherence to the EAT-Lancet Diet, Genetic Predisposition, and Risk of Kidney Stone Disease kidney stones cohort study genetics obesity
- Why Is One-Third of Male Infertility Unexplained?2026-03-14
Male infertility causes 20–30% of all infertility cases globally, yet 30–40% of cases have no identified cause
Epidemiology, Etiopathogenesis, Diagnosis, and Treatment of Male Infertility — Current Trends and Future Directions: A Narrative Review male infertility epigenetics environmental exposure biomarkers
- Mood, Not Birth Method, Drives Postpartum Sexual Dysfunction2026-03-14
Sexual function scores hit a nadir 6–8 weeks postpartum and depression predicted decline better than delivery mode or breastfeeding
Longitudinal Trajectories and Psychosocial Predictors of Postpartum Sexual Dysfunction from Early Pregnancy to 12 Months Postpartum sexual dysfunction women's health pregnancy biomarkers
- Welding May Triple Testicular Cancer Risk — But the Data Is Thin2026-03-14
Regular welders had a non-significant 2× elevated testicular cancer risk; non-seminoma risk tripled, but rests on very few cases
Risk of Testicular Cancer and Exposure to Welding Fumes testicular cancer environmental exposure occupational exposure case-control study
- Penile Cancer's RNA Biomarkers: Big Promise, Small Studies2026-03-13
A Brazilian review catalogs miRNAs tied to penile cancer progression and HPV status — but the underlying studies are nearly all too small and descriptive to act on
MicroRNAs in Penile Cancer: Challenges, Opportunities, and Translational Perspectives penile cancer biomarkers genomics HPV narrative review
- The Preventable Cancer Quietly Killing Old Men2026-03-13
Penile cancer incidence is rising in wealthy countries, mortality peaks in men 75+, and two treatable precursor conditions drive most cases
Penile Cancer-A Preventable Cause of Death in Elderly Men penile cancer HPV screening surgical outcomes
- Impressive Kidney Stone Numbers, Massive Asterisk2026-03-13
Suction-enabled access sheaths nearly 6x the odds of clearing kidney stones—but 87% heterogeneity makes that number nearly meaningless
Efficacy and Safety of Flexible and Navigable Suction Ureteral Access Sheath Versus Conventional Ureteral Access Sheath in Retrograde Intrarenal Surgery: An Updated Systematic Review and Meta-Analysis kidney stones meta-analysis surgical outcomes
- Fixing a Fertility Problem Also Lifts Testosterone2026-03-13
Varicocele repair raised testosterone by 80-100 ng/dL on average, per a review of existing studies
Varicocele and low testosterone varicocele hypogonadism testosterone male infertility narrative review
- New Kidney Stone Surgery Bleeds Less, Clears as Well2026-03-12
Meta-analysis of 3 RCTs (n=1,020) finds FANS-RIRS matches mini-PCNL for stone clearance but cuts hemorrhage risk by 92% and shortens hospital stay by 1.75 days
Efficacy and Safety of FANS-RIRS Versus Mini-PCNL for 2–3 cm Renal Stones: A Systematic Review and Meta-Analysis of RCTs kidney stones meta-analysis surgical outcomes evidence quality
- Sperm-Only Ion Channels Could Enable Male Contraception2026-03-12
A review of the ion transport machinery in sperm membranes — some of it unique to sperm — and why mutations in these systems cause infertility
The systems that transport ions and their impact on sperm function and male fertility. male infertility sperm capacitation genetics contraception narrative review
- 51% Needed Reoperations — 97% Still Don't Regret It2026-03-12
Half of patients required unplanned reoperations; only 2.9% of adolescents later reported decisional regret about early surgery.
Adolescent Satisfaction and Decisional Regret After Hypospadias Repair in Early Childhood hypospadias pediatric urology surgical outcomes patient satisfaction
- When Your Body Attacks Your Own Sperm2026-03-12
Editorial overview of a themed issue: blood-testis barrier, antisperm antibodies, seminal cytokines, and genital pathogens as fertility disruptors
Male Infertility and Immune Function immunology male infertility semen quality systematic review narrative review inflammation antisperm antibodies
- One Surgeon's Opinion Dressed Up as a Literature Review2026-03-12
A "comprehensive" review of varicocele surgery for testicle pain ends in personal opinion, not pooled data
Varicocele repair for chronic orchialgia varicocele testicular disease narrative review evidence quality
- Kidney Stone Genes: Who Actually Needs Testing?2026-03-12
Review finds genetic testing pays off in high-risk cases, but polygenic risk scores remain unproven for most patients
Genetic Testing and Personalized Treatment for Kidney Stone Formers kidney stones genetics genomics evidence quality
- Does Your Doctor Ask About Your Sex Life?2026-03-11
A 2026 review maps primary care's role in four sexual health conditions: ED, premature ejaculation, sexual pain, and low desire.
Addressing Sexual Health in Primary Care erectile dysfunction premature ejaculation sexual dysfunction health services narrative review
- MS Ruins Sex Life—For Nearly Everyone. Sample: 372026-03-11
87.5% of men with relapsing-remitting MS screened positive for ED in a 37-person self-selected online survey
Hidden Challenges: A Cross-Sectional Study on Prevalence and Determinants of Sexual Dysfunction in Men and Women with Multiple Sclerosis sexual dysfunction erectile dysfunction cross-sectional multiple sclerosis
- HPV Raises Antisperm Antibodies Tenfold2026-03-11
GU infections were linked to measurable sperm parameter declines, but pregnancy outcomes mostly held — HPV was the outlier, with a tenfold antisperm antibody spike
Impact of Male Genital Tract Infections on Semen Quality: A Systematic Review and Meta-Analysis male infertility semen quality systematic review meta-analysis HPV antisperm antibodies inflammation
- When Your Immune System Attacks Your Sperm2026-03-09
Antisperm antibodies affect 5–12% of infertile men; immunosuppression was abandoned as ineffective — ICSI now mechanically bypasses the immune barrier at >80% antibody binding
Antisperm Antibodies and Autoimmunity in the Era of Assisted Reproduction male infertility immunology antisperm antibodies narrative review
- Mapping What Nurses Actually Do for ED2026-03-09
A systematic review of 14 studies maps RN and NP roles in ED care — organizational, not clinical
Nurses' Roles in Managing Erectile Dysfunction: A Mixed-Method Systematic Review erectile dysfunction
- Testosterone Rescues Muscle Loss on Tirzepatide2026-03-09
Adding TRT to tirzepatide in 5 non-responding men preserved lean mass and doubled physical activity at 6 months
Effects of Testosterone Undecanoate as Add-On Therapy in Obese Hypogonadal Men That Are Late Responders to Tirzepatide: A Pilot Study hypogonadism obesity testosterone therapy erectile dysfunction metabolic syndrome
- Three Metabolic Flags for Silent Heart Damage in ED Men2026-03-09
Dyslipidemia more than doubled the odds of diastolic heart dysfunction in 398 men with ED; BMI was the only factor linking to both types
Risk Factors Associated with Cardiac Dysfunction in Men with Erectile Dysfunction erectile dysfunction cardiovascular disease cross-sectional metabolic syndrome biomarkers
- Four Guideline Panels, Four Different Playbooks2026-03-08
Four major urology societies agree on diagnosis basics but split on when to treat and what works—mostly because the evidence is thin.
Guideline of Guidelines: Peyronie's Disease Peyronie's disease evidence quality erectile dysfunction surgical outcomes
- Half of Asthma Patients Report Sexual Dysfunction2026-03-08
Meta-analysis found sexual dysfunction in 54% of asthma patients and 19% with atopic dermatitis
Global Prevalence of Sexual Dysfunction in Individuals With Atopic Dermatitis and Asthma: A Systematic Review and Meta-Analysis sexual dysfunction meta-analysis systematic review epidemiology
- Gum Disease and Infertility: Mostly Speculation So Far2026-03-08
A narrative review argues gum disease may worsen fertility via inflammation, but admits the human data barely supports it
Infertility and Periodontitis: Are We Connecting the Right Dots? infertility male infertility inflammation oxidative stress narrative review
- Your Antipsychotic Determines Which Sexual Side Effect You Get2026-03-07
Aripiprazole flagged for compulsive sexual behavior (ROR: 296.23); risperidone and paliperidone linked to decreased libido and anorgasmia — signals vary sharply by drug
Female Sexual Dysfunction Induced by Second-Generation Antipsychotic Drugs — A Disproportionality Analysis Based on the FAERS Database sexual dysfunction women's health antipsychotics pharmacovigilance
- In Cryptorchidism, the Support Cells Fail First2026-03-07
In a mouse cryptorchidism model, Sertoli and peritubular myoid cells show stress signals within 3 days — before germ cells begin dying
Somatic Cell Dysfunction Precedes Testicular Degeneration in a Surgical Model of Cryptorchidism cryptorchidism animal study pediatric urology spermatogenesis
- Shockwave ED Stats Look Good. Patients Disagree.2026-03-07
LI-ESWT improved IIEF scores across 19 RCTs, but most studies failed to reach the minimally clinically important difference
A Close Look at the Evidence on Low-Intensity Shockwave Therapy in Erectile Dysfunction — A Systematic Review and Meta-Analysis of Randomized Controlled Trials erectile dysfunction meta-analysis evidence quality sexual dysfunction
- Poor Sperm, Worse Health: The Iceberg Below2026-03-06
Review argues 1–6% of infertile men have undetected life-threatening pathology, yet workup stops at semen analysis
Is Male Infertility an Early Warning of More Serious Diseases? male infertility genetics semen quality biomarkers
- Most ED Evidence Is Garbage2026-03-06
95% of treatment evidence rated low or very low quality across 23 meta-analyses
Current treatment for erectile dysfunction: an umbrella review of systematic reviews and meta-analyses erectile dysfunction evidence quality meta-analysis
- Dirty Air, Worse Sperm: Meta-Analysis Confirms2026-03-06
Four meta-analyses pooled: air pollution correlates with modestly lower sperm motility, concentration, and morphology
Air pollution and male infertility: A meta-umbrella study of evidence on semen quality male infertility air pollution semen quality meta-analysis
- Two IPP Brands, One Conflicted Reviewer2026-03-05
Narrative review declares both major IPP brands roughly equivalent — written by an author with industry ties to both manufacturers
Three-Piece Inflatable Penile Prosthesis Implantation in Clinical Practice penile prosthesis erectile dysfunction surgical outcomes evidence quality
- Lichen Extract Nearly Triples Sperm Motility — In Rats2026-03-05
Atranorin, a lichen-derived compound, restored sperm motility by 189% and testosterone by 90% in alloxan-diabetic rats at 170 mg/kg.
Extraction, Characterization, and Biological Evaluation of Atranorin Against Diabetes-Induced Reproductive Dysfunction Through Modulation of Oxidative Stress, Inflammatory Pathways and Key Reproductive Enzymes animal study male infertility oxidative stress semen quality testosterone
- Breaking Kidney Stones While You're Wide Awake2026-03-05
Early clinical data suggests BWL fragments kidney and ureteral stones in awake patients with mostly minor side effects — but the evidence base is still thin.
Burst Wave Lithotripsy: Insights on Effectiveness and Safety kidney stones narrative review surgical outcomes
- Stone Prevention: APPs In, Oversight Out2026-03-05
Survey of 69 urologists finds APPs handle stone prevention in ~half of U.S. practices, with half those practices reporting no formal physician oversight
Integrating Advanced Practice Providers in Kidney Stone Prevention: Patterns, Barriers, and Opportunities kidney stones health services evidence quality
- When a Boy's Anatomy Needs Genetic Answers First2026-03-04
In 43 children with proximal hypospadias, every patient had severe ventral chordee and most had an underlying disorder of sex development requiring workup before surgery
In Which Cases of Proximal Hypospadias Detailed Investigations Are Necessary pediatric urology cryptorchidism surgical outcomes hypospadias
- Can AI Read Sperm Better Than Humans?2026-03-03
Systematic review maps AI applications in male fertility — sperm analysis, treatment prediction — but reports no pooled numbers
Artificial Intelligence and Infertility: A Systematic Review male infertility systematic review semen quality artificial intelligence
- Plastics at Birth, Testicular Cancer Later?2026-03-03
Newborn blood spots show phthalate mixtures at birth may predict testicular cancer decades later
Phthalates measured at birth and risk of testicular cancer in adolescents and young adults. testicular cancer environmental exposure
- Old Prostate Exam Survives the MRI Era2026-03-03
A 164-patient retrospective found suspicious DRE was present in 48.5% of clinically significant prostate cancer cases and correlated with advanced pathological stage (≥pT3)
In the Era of mpMRI and PSMA PET/CT: Does Digital Rectal Examination Still Matter? prostate cancer screening retrospective cohort surgical outcomes biomarkers
- Iron Overload May Drive Kidney Stones2026-03-03
NHANES cross-section finds dietary iron intake and transferrin saturation independently associated with kidney stone formation
Dysregulated Iron Metabolism and Kidney Stone Risk: An Epidemiological and Experimental Study kidney stones iron metabolism
- The 'We Don't Know' Label Hiding Oxidative Damage2026-03-03
Up to 40% of male infertility is labeled "idiopathic" — this review argues that's a diagnostic failure, not a biological reality
Idiopathic Male Infertility Revisited: Can Redox Endophenotypes Reframe the 'Idiopathic' Label? male infertility oxidative stress biomarkers spermatogenesis
- Shockwave Therapy for ED Fades After 12 Months2026-03-02
Li-ESWT pushed IIEF-EF from 11 to 21 at 12 months in 188 PDE5-refractory men — but scores slipped to 18 by 18 months
Low-Intensity Extracorporeal Shock Wave Therapy in Vasculogenic ED Refractory to PDE5 Inhibitors: A Prospective Study with 12- and 18-Month Outcomes erectile dysfunction vascular health evidence quality
- Vitamins Nudge Sperm Motility, Not Much Else2026-03-02
Antioxidant/vitamin combo raised sperm motility from 17% to 24% in infertile men — statistically significant, still well below normal
Therapeutic Supplementation With Antioxidants and Vitamins Improved Sperm Motility Among Infertile Men With Idiopathic Low Spermatogenesis male infertility oxidative stress spermatogenesis semen quality cohort study
- 1 in 4 Infertile Women at Risk for Sexual Dysfunction2026-03-01
25% of women and 7% of men newly diagnosed with unexplained infertility screen positive for sexual dysfunction
Sexual Functioning and Its Determinants in Couples with Unexplained Infertility infertility sexual dysfunction
- 92% Continence After Prostate Surgery — No Robot Required2026-03-01
360-patient Italian series reports 92.5% continence and 83% erectile function recovery at 6-12 months with 3D laparoscopy, no robotic platform
3D Laparoscopic Radical Prostatectomy: The Romolo Hospital Experience prostate cancer surgical outcomes urinary incontinence erectile dysfunction robotics
- Lab-Grown Sperm: Closer, But Not There2026-03-01
Narrative review maps iPSC-to-sperm progress — validated precursor cells exist, but maturation to functional sperm remains unsolved
The road to restore male fertility using in vitro-derived germ cells male infertility infertility genetics stem cells
- Lifestyle Trims Help Sperm; Surgery Doesn't2026-03-01
Losing weight may help sperm quality, but the method matters—and most of the evidence is weak
The effect of obesity interventions on male fertility: a systematic review and meta-analysis male infertility obesity meta-analysis
- COVID-19 Damages Sperm. Five Measures Down.2026-03
This meta-analysis of cohort studies found statistically significant reductions in sperm concentration, count, motility, and DNA fragmentation index following SARS-CoV-2 infection.
The Impact of SARS-CoV-2 on Male Infertility: A Systematic Review and Meta-Analysis of Cohort Studies male infertility semen quality meta-analysis COVID-19 DNA fragmentation
- Mom's Diet Shapes Her Son's Sperm, in Cattle2026-03
Genetics explains only ~15% of male infertility; a cattle review argues epigenetic marks fill the gap — and pass across generations
Bull Fertility and Epigenetics: Exploring Influences Beyond Genetics animal study male infertility genetics epigenetics biomarkers
- Three in Four Transplant Women Never Asked About Sex2026-03
74% of female transplant recipients reported no provider had asked about sexual health in the past year
Study of Sexual Health in Peri and Postmenopausal Solid Organ Transplant Recipients sexual dysfunction women's health survivorship cross-sectional
- One in Four Penile Implants Needs Revision2026-02-28
24% of patients required reintervention over a median 39-month follow-up; median prosthesis survival was 7 years, but no independent risk factors were confirmed.
Prolonged Survival and Risk Factors for Reintervention After Inflatable Penile Prosthesis Implantation erectile dysfunction penile prosthesis surgical outcomes
- One Gene Knockout Tanks Sperm Count in Mice2026-02-28
Germ-cell deletion of TNXB in mice causes testicular atrophy, tubular degeneration, and near-total loss of spermatogenesis
TNXB Regulates Spermatogenesis by Maintaining Cytoskeleton and Cell Junction Stability male infertility genetics animal study semen quality
- Wheat Protein Tanks Rat Testosterone and Sperm2026-02-27
Wheat germ agglutinin at 250 mg/kg/day impaired sperm quality, cut testosterone, and damaged testicular tissue in prepubertal rats across 2–10 weeks
From Food to Infertility: Disruption of the Male Reproductive Axis by Wheat Lectin in Rats animal study male infertility oxidative stress spermatogenesis
- Lead Ages Immune Cells. Those Cells Tank Your Sperm.2026-02-27
A 170-man study linked urinary lead and cadmium to lower sperm motility; mouse work traced the mechanism to senescent immune cells in the epididymis.
Epididymal Macrophage Senescence Contributes to Sperm Motility Decrease upon Environmental Stress male infertility environmental exposure immunology animal study cross-sectional semen quality
- The Testicular "Heart Attack" That Wasn't Torsion2026-02-27
A single case of segmental testicular infarction resolved with heparin — no surgery, no orchiectomy
Segmental Testicular Infarction: A Case Report testicular disease case report
- Nurse Counseling Barely Moves Prostate Cancer Sex Scores2026-02-27
14-study meta-analysis finds nurse-led psychoeducational programs improve sexual function (SMD=0.31) and satisfaction (SMD=0.27) — effects just clear zero
Cancer Nursing Interventions for Sexual Function and Satisfaction in Men with Prostate Cancer: A Systematic Review and Meta-analysis prostate cancer meta-analysis sexual dysfunction survivorship
- Horny Goat Weed Gets a Mechanistic Review2026-02-26
A narrative review maps how icariin, horny goat weed's active compound, may improve sperm function — mostly in rodents
Icariin in Male Reproduction: Multi-Target Pharmacological Mechanisms and Therapeutic Potential traditional chinese medicine male infertility oxidative stress animal study spermatogenesis
- Can Protein Tangles Kill Prostate Cancer Cells?2026-02-25
Review surveys disulfidptosis — a newly described cell death mechanism — as a theoretical target in prostate, testicular, and bladder cancer; no original data
Disulfidptosis and Androgenic Cancers: From Molecular Mechanisms to Clinical Applications and Future Translational Research prostate cancer testicular cancer pathology oxidative stress
- The Penile Implant Germany Won't Use2026-02-25
Germany implants far fewer penile prostheses than evidence warrants — and the authors say structural barriers, not lack of efficacy, are to blame
Penile Implant Surgery in Germany — Effective, Established, Yet Underused penile prosthesis erectile dysfunction health services surgical outcomes
- Nobody Diagnosed Opioid Hypogonadism. Not Once.2026-02-24
57% of long-term opioid users had at least one hormone disorder; quitting dropped hypogonadism prevalence from 27% to 3%
Endocrinopathies and Their Recovery in a 20-Year Cohort Study of People With Heroin Dependence hypogonadism testosterone mental health longitudinal study opioids
- Sexual Dysfunction as a Heart Disease Early Warning2026-02-22
ED may flag cardiovascular disease years before symptoms — the evidence for women lags far behind
Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective erectile dysfunction cardiovascular disease sexual dysfunction
- SSRIs Triple Orgasm Dysfunction Risk2026-02-21
High-certainty meta-analysis of 13 RCTs, but all data is from 1990–2014
Sexual dysfunction associated with selective serotonin reuptake inhibitors in adults with depression: a systematic review and meta-analysis sexual dysfunction antidepressants
- TRT: Lower Prostate Cancer, Higher BPH Risk2026-02-20
A Medicare study of 547K men found TRT linked to 16% lower prostate cancer hazard but 13% higher BPH risk
Association Between Testosterone Replacement Therapy and Prostatic Disorders in Elderly Hypogonadal Men hypogonadism prostate cancer BPH testosterone therapy
- AMH Flags Azoospermia But Can't Predict Sperm Count2026-02-20
AMH is lower in men with non-obstructive azoospermia, but doesn't independently predict sperm concentration once FSH and testicular volume are accounted for
Serum Antimüllerian Hormone as a Biomarker of Functional Testicular Reserve: A Comparative Analysis male infertility biomarkers semen quality infertility
- Male Infertility Tests Haven't Changed in a Decade2026-02-20
A review of upcoming fertility tests genomics, AI, imaging with zero new data of its own
Emerging Diagnostics Tools for Severe Male Infertility and Non-obstructive Azoospermia male infertility genomics artificial intelligence biomarkers narrative review
- Half of Klinefelter Men Have Fatty Liver2026-02-20
Nearly half of Klinefelter patients had fatty liver, driven by metabolic syndrome — not low testosterone
Metabolic Dysfunction-associated Steatotic Liver Disease in Klinefelter Syndrome: High Prevalence Uncovers an Unmet Need hypogonadism genetics cardiovascular disease metabolic syndrome
- Osteoporosis Drug Fails Oligospermia Trial2026-02-20
Denosumab 60 mg produced no improvement in sperm concentration over placebo in 39 men with severe oligospermia
Effect of Denosumab on Sperm Concentration in Men With Severe Oligospermia: A Randomized Controlled Trial male infertility semen quality infertility
- Does Iron Boost Testosterone? Barely2026-02-20
Serum iron associates with testosterone in middle-aged men — but the causal story is murkier than the headline suggests
Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies iron metabolism biomarkers genetics hypogonadism
- The Infertility Fallback Guide Ferring Helped Write2026-02-19
Industry-sponsored "expert opinion" recommends gonadotropins + hCG luteal support when pulsatile GnRH therapy is unavailable — no original data included
Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion. infertility women's health evidence quality hypogonadism
- Blood Test Predicts Who Survives Salvage Chemo for Testicular Cancer2026-02-19
In relapsed germ cell tumors, a liquid biopsy tumor fraction above threshold predicted significantly worse OS; miR-371a-3p did not.
Impact of Circulating Tumor DNA and Copy-Number Alterations on Clinical Outcome in Relapsed/Refractory Germ Cell Tumors Treated With Salvage High-Dose Chemotherapy testicular cancer biomarkers genomics cohort study
- Inflammation Scores Track With Lower Testosterone2026-02-18
In 7,576 men from NHANES, higher composite inflammation scores independently predicted lower total and free testosterone — but the age-stratified FT findings raise questions
Association Between Chronic Inflammation Status and Serum Testosterone and Free Testosterone in Adult Males cross-sectional testosterone hypogonadism biomarkers inflammation
- After Pelvic Radiation, Sexual Recovery Is Partial2026-02-18
26 studies, 5,646 patients: pelvic radiation reliably causes vaginal dryness, dyspareunia, and lasting sexual dysfunction — dilation helps some, not all
A Systematic Review of Patient-Reported Outcomes on the Impact of Radiation Therapy on Sexual Health in Patients With Gynecologic Cancer systematic review sexual dysfunction cancer survivors women's health survivorship quality of life
- Gene Variant Predicted Zero Sperm in Every Case2026-02-18
Biallelic MEI1 mutations found in 1.9% of azoospermic men; surgical sperm retrieval failed 12/12 times
A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics. genetics genomics male infertility spermatogenesis
- CBAVD Sperm Retrieval: No One Agrees2026-02-18
Among 51 reproductive urologists, no extraction technique dominated: testicular (39%), epididymal (29%), or a combination (31%)
Reproductive Urologist Preferences for Sperm Extraction in Congenital Bilateral Absence of the Vas Deferens male infertility health services surgical outcomes genetics
- Diet Sweeteners Flag a Fertility Gene — In Mouse Cells2026-02-17
Computational screening flagged aspartame, neotame, and sucralose as reproductive toxins targeting FGFR1; validated only in mouse Leydig cells in a dish
Artificial sweeteners and male infertility: Network toxicology and experimental evidence reveal FGFR1 as the critical target. male infertility environmental exposure animal study spermatogenesis
- Vanished Testicles Rarely Harbor Cancer Risk2026-02-14
In 262 boys with absent testes, only 1.1% of remnants contained viable germ cells — and no malignancy was found in 15 years.
Testicular Regression Syndrome Revisited: Insights from a 15-Year Retrospective Study and Evolving Perspectives on Management pediatric urology cryptorchidism testicular disease surgical outcomes retrospective cohort
- TCM for ED: Mostly Animal Data, Few Clinical Trials2026-02-13
A narrative review of TCM mechanisms for ED — heavy on preclinical theory, thin on human evidence
Mechanism of traditional Chinese medicine in treating erectile dysfunction: A review erectile dysfunction traditional chinese medicine animal study
- Cisplatin's Kidney Damage Cascades Into Heart Disease2026-02-13
41% of testicular cancer survivors had reduced kidney function a decade post-chemo; it cascades into hypertension, hyperlipidemia, and CVD
Renal Impairment and Late Toxicities Comparing Contemporary Chemotherapy Regimens for Testicular Cancer in a Real-World Setting testicular cancer survivorship cardiovascular disease vascular health
- The Cleanup Crew Sperm Can't Live Without2026-02-13
Review surveys mouse knockout evidence linking ubiquitin-editing enzymes to spermatogenic failure; no human clinical data
The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility male infertility genetics animal study spermatogenesis
- AAS and ED: Most Reviews Nearly Worthless2026-02-12
Six systematic reviews on AAS-induced ED: four rated critically low confidence, one low, one medium
Erectile Dysfunction and Related Variables Due to Anabolic Steroid Use: A Review of Reviews erectile dysfunction hypogonadism systematic review evidence quality anabolic steroids
- Can a Blood Draw Replace Testicular Cancer Imaging?2026-02-11
Rising TGCT incidence, murky risk factors, and two emerging biomarkers — a military urology team surveys the field
Decoding testicular germ cell tumors: integrating risk, biology, and biomarkers into future care testicular cancer biomarkers genetics
- Insulin Resistance Linked to Softer Erections2026-02-11
Higher TyG index — a proxy for insulin resistance — correlated weakly with lower penile rigidity on objective testing (r = −0.22 at best)
Association Between Triglyceride-Glucose Index and AVSS-RigiScan Test Parameters in Men With Erectile Dysfunction erectile dysfunction metabolic syndrome biomarkers vascular health
- Why Some Sperm Can't Swim: A Molecular Tag2026-02-09
Kmal levels were significantly elevated in asthenozoospermic men and inversely correlated with progressive motility across 94 participants
Lysine Malonylation Regulates Human Sperm Motility male infertility semen quality spermatogenesis biomarkers
- Plant Compound Cuts Kidney Crystals—In Mice Only2026-02-09
Luteolin reduced calcium oxalate crystal deposition in mice and blocked PI3K/Akt signaling in kidney cells—no human data.
Luteolin Prevents Hyperoxaluria-Induced Renal Injury by Inhibiting Crystal Deposition and Renal Inflammation kidney stones animal study inflammation traditional chinese medicine
- Which SSRI Hits Male Sexual Function Hardest?2026-02-07
Escitalopram and citalopram showed the strongest ED signals (ROR ~8) across 6.6 million FAERS reports; fluvoxamine's signal didn't reach significance
Male Sexual Dysfunction Associated with Selective Serotonin Reuptake Inhibitors (SSRIs): A Pharmacovigilance Disproportionality Analysis of FAERS Data antidepressants erectile dysfunction pharmacovigilance sexual dysfunction
- It's Not Age That Tanks Testosterone2026-02-06
Review of current evidence finds aging alone doesn't cause low T — obesity and diabetes do, and recent RCTs report no added cardiovascular risk from treatment
Functional Testosterone Deficiency in Aging Men: Clinical Impact, Diagnostic Pathways, and Treatment Strategies hypogonadism testosterone therapy metabolic syndrome narrative review
- Scrotal Calcifications Don't Trigger Immune Attack2026-02-06
In 1,755 infertile men, testicular microlithiasis was not associated with higher antisperm antibody rates (1.2% vs 3.5%, p=0.17)
Testicular Immune Privilege Maintained in Incidental Testicular Microlithiasis: Evidence from 1755 Infertile Men testicular disease infertility immunology semen quality
- Ultrasound Pattern Could Spare Testicles From Surgery2026-02-06
17 men with testicular sarcoidosis had tiny, stable nodules that mimicked cancer on ultrasound
Multiparametric Ultrasound Findings of Testicular Sarcoidosis testicular disease case report pathology testicular cancer
- Same DNA Repair Flaw, Infertile Men and Women2026-02-05
Exome sequencing of three consanguineous families found homozygous loss-of-function variants in SPIDR, TOP6BL, or RAD51AP2 — all meiotic DNA repair genes — causing infertility in both sexes.
Disruption of Meiotic Double-Strand Break Dynamics Provokes Germline Human Infertility in Both Sexes genetics male infertility infertility spermatogenesis
- One in Four Penile Implant Patients Loses Glans Sensitivity2026-02-05
116 men followed 6+ years after infrapubic penile implant: 27% developed glans numbness, 9.5% needed reoperation
Infrapubic Approach for Inflatable Penile Prosthesis: Perioperative and Long-Term Outcomes penile prosthesis erectile dysfunction surgical outcomes
- Menopause Hurts Sex. Here's What Actually Helps.2026-02-04
A Stanford review surveys GSM treatments — hormonal, nonhormonal, and device-based — without reporting a single effect size
The New Toolbox for Reducing Painful Sex in Menopause sexual dysfunction women's health evidence quality menopause
- Single-Cell Map Reveals Penile Cancer's Immune Blind Spots2026-02-04
A 66,421-cell atlas of penile squamous cell carcinoma identifies SEMA3C-high tumor cells and exhausted T cells as key drivers of metastasis
Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single-Cell RNA Sequencing penile cancer biomarkers immunology genetics
- One Mouth Graft, Near-Zero Failures in Pediatric Urethral Repair2026-02-04
Lip mucosa grafted dorsally onto the urethra cut stricture recurrence to 4.5% over a median 6-year follow-up in 22 boys
Dorsal Onlay Oral Mucosa (DOOM) Urethroplasty for Post-Hypospadias Stricture hypospadias pediatric urology surgical outcomes retrospective cohort
- Sertoli vs. Leydig: New Marker, Tiny Sample2026-02-03
LEF1 stained positive in all 5 Sertoli cell tumors and zero of 12 Leydig cell tumors — promising signal, absurdly small dataset
LEF1 and IL13RA2 in Testicular Sex Cord-Stromal Tumors: LEF1 as a Potential Diagnostic Marker for Sertoli Cell Tumors testicular cancer pathology biomarkers retrospective cohort
- Half of Infertility Is Male, Insurance Barely Covers It2026-01-30
Male factor drives up to 50% of infertility cases, yet insurance and specialist access lag far behind
Barriers to Male Infertility Care and Strategic Solutions for Advancement: Increasing Access, Health Policy, and Advocacy Efforts male infertility health services narrative review screening
- One in Four "Causative" IHH Variants: Actually Benign2026-01-30
When re-scored by ACMG standards, 26% of reported "causative" IHH/Kallmann variants were benign — and ClinVar confirmed only 18% as pathogenic
Overestimation of Pathogenic Variants in Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome genetics genomics hypogonadism evidence quality
- Nerve-Sparing Rectal Surgery Still Harms 1 in 132026-01-30
Nerve-preserving rectal resection cut post-op sexual dysfunction to 7.7%, but IIEF-5 scores still fell significantly at 6 months.
Laparoscopic Rectal Cancer Resection With Pelvic Autonomic Nerve Preservation in Males: A Prospective Single-Center Study sexual dysfunction surgical outcomes
- Ginseng Compound Raises Testosterone — In Obese Mice2026-01-28
A ginseng-derived compound raised testicular testosterone in high-fat-diet mice by activating the cAMP/PKA/CREB pathway — no human data yet
Ginsenoside Rf Promotes Testosterone Synthesis Through the cAMP/PKA/CREB Signaling Pathway to Improve Obesity-Related Male Hypogonadism animal study hypogonadism testosterone obesity traditional chinese medicine
- Your Partner's Bacteria Can Shift Your Sperm2026-01-27
Anaerobe-heavy seminal profiles correlate with higher sperm DNA fragmentation and lower motility; Lactobacillus-rich profiles align with better DNA integrity
Micromanagement: How the Male Reproductive Microbiome Shapes Male Fertility male infertility semen quality DNA fragmentation oxidative stress inflammation
- X-Linked Gene Found in Sperm Failure, Monkeys Confirm It2026-01-27
A primate-exclusive X-linked gene, TFDP3, was defective in 8 infertile men with OAT — and silencing it in monkeys replicated the phenotype
Deficiency of Primate-Specific TFDP3 Causes Male Infertility with Oligoasthenoteratozoospermia in Humans and Cynomolgus Monkeys genetics male infertility spermatogenesis animal study
- Childhood Obesity Shrinks Testicles Before Puberty Starts2026-01-27
Obese prepubertal boys had smaller testicular volume, shorter penis length, and lower testosterone than normal-weight peers in a 60-boy study.
Obesity Impairs Male Reproductive Development in Prepubertal Boys via Local Adipose Tissue Inflammation and the STAT3/CYP19A1 Pathway obesity male infertility testosterone pediatric urology inflammation animal study
- Rare Testicular Tumors Get Diagnostic Clarity2026-01-26
Review maps how BAP1 and MTAP immunostaining now separate benign from malignant mesothelial lesions of the tunica vaginalis
Mesothelial Lesions of the Testis: A Review pathology testicular disease testicular cancer biomarkers
- Gene Variant Floods Sperm With Chromosome Errors2026-01-25
A single inherited frameshift variant left 18.8% of one man's sperm missing sex chromosomes entirely — and drove repeated miscarriages
Homozygous C12orf40 Variant Contributes to Severe Oligoasthenoteratozoospermia and Sperm Sex Chromosome Aneuploidy genetics male infertility spermatogenesis case report pregnancy
- More Kidney Stones, Worse Erections — But Why?2026-01-23
202 kidney stone patients surveyed: men with recurrent stones showed worse erectile function, women reported low arousal regardless of stone burden
Evaluating the Sexual Quality of Life of Kidney Stone Formers: A Multicentric Cross-Sectional Study kidney stones erectile dysfunction sexual dysfunction cross-sectional women's health
- HPV Splits Penile Cancer Into Two Paths2026-01-22
Moffitt Cancer Center classifies intraepithelial penile lesions by HPV status and cancer risk
Intraepithelial Penile Lesions penile cancer pathology
- Varicocele Surgery Rescues Sperm in Half of Near-Zero Cases2026-01-21
54% of men with cryptozoospermia (near-zero sperm) improved to at least oligozoospermia after varicocele repair in a 24-man study
Semen Parameter Response to Varicocele Repair in Infertile Men With Cryptozoospermia varicocele male infertility semen quality surgical outcomes retrospective cohort
- Testicular Macrophages Do More Than We Thought2026-01-21
Review maps macrophage roles in testicular disease but produces no original data
Decoding mechanisms and therapeutic opportunities in testicular development diseases through macrophage immunology testicular disease immunology
- The Cell-Recycling Process Tied to Broken Sperm2026-01-20
A review of animal and lab data argues autophagy imbalance may drive low sperm count and motility, no new evidence
A narrative review on the role of autophagy in male infertility-associated sperm abnormalities autophagy male infertility spermatogenesis narrative review
- Men Think Average Is Small. Research Agrees They're Wrong.2026-01-20
Only 7 studies exist on this topic — all found men overestimate what's "normal" in size and sexual performance while underestimating their own normalcy
Are Men Aware of Normal Penile Length and Sexual Function? A Narrative Review narrative review sexual dysfunction erectile dysfunction evidence quality
- A Stain That Spots Penile Precancer2026-01-20
New IHC marker GATA3 lost in 87–100% of HPV-independent penile intraepithelial neoplasia, potentially resolving a longstanding diagnostic ambiguity
GATA3 Is Underexpressed in Penile Neoplasia: Potential Implications in Diagnosis and Pathogenesis penile cancer pathology biomarkers HPV
- Rare Scrotal Cyst Mistaken for Tumor, Costs a Testicle2026-01-19
Meconium periorchitis — a sterile scrotal mass affecting 1 in 30,000 newborns — is routinely misdiagnosed as teratoma, potentially driving unnecessary orchiectomy
Meconium Periorchitis case report pediatric urology testicular disease pathology
- Nearly All HIV-Positive Women in Study Report Low Libido2026-01-16
53% of sexually active HIV-positive women met criteria for sexual dysfunction; 94% screened positive for hypoactive sexual desire.
Sexual Dysfunction and Hypoactive Sexual Desire in Women Living With HIV in Ceará, Brazil: A Cross-Sectional Study sexual dysfunction HIV women's health cross-sectional
- 60% of Women With Parkinson's Report Sexual Dysfunction2026-01-16
60.7% of women with Parkinson's had sexual dysfunction vs 17.9% of controls — but the two measurement scales disagreed
Sexual Dysfunction in Parkinson's Disease: What About Women? sexual dysfunction women's health cross-sectional Parkinson's disease
- PRP for Peyronie's? Small Study, Smaller Effect2026-01-14
38 men got PRP injections plus two other therapies; curvature dropped 10 degrees, but nobody can say which part worked
Trimodal Mini-Invasive Therapy for Stable-Phase Peyronie's Disease: A Two-Center Real-Life Prospective Pilot Study Peyronie's disease sexual dysfunction quality of life
- Three Cuts, 99% Straight: A Severe Hypospadias Series2026-01-13
Three ventral corporotomies alone corrected penile curvature in 81% of cases; adding one dorsal plication pushed success to 99% across 400 patients
Efficacy of Three Corporotomies to Correct Ventral Penile Curvature in 400 Patients With Severe Hypospadias hypospadias pediatric urology surgical outcomes
- More Soy, Fewer Sperm? Japanese Data Stirs the Debate2026-01-13
Men in the top daidzein quartile had 32–40% lower sperm counts than lowest-quartile men — but this is cross-sectional data from a fertility clinic.
Urinary Isoflavone Concentrations and Semen Parameters of Japanese Men Seeking Fertility Treatment male infertility semen quality environmental exposure cross-sectional epidemiology
- Blood Flow Physics May Explain ED2026-01-13
A narrative review of how mechanical force on vessel walls drives—or disrupts—the biology of erection
Exploring the Application of Shear Stress in Erectile Dysfunction erectile dysfunction vascular health
- When Infertility Care Forgets the Man2026-01-13
Male factor causes about half of infertility cases yet men are often left out of their own care
Procreation, Potency, and the Price of Paternity: The Social and Psychological Impact of a Diagnosis of Male Factor Infertility male infertility mental health infertility relationship health
- 67 Sperm Risk Factors, Almost All Weak Evidence2026-01-13
67 risk factors linked to male infertility catalogued — but 78% of the underlying evidence rated low or very low quality
Current Risk Factors for Male Infertility and Semen Parameters: An Umbrella Review of Systematic Reviews and Meta-Analyses male infertility semen quality evidence quality environmental exposure systematic review meta-analysis
- Hypospadias Surgeons Admit They're Undertrained2026-01-12
103 surveyed surgeons reported a gap between the case volume needed for competency and what residency actually delivers
Education and Training in Hypospadias Surgery: Current Status, Competency Assessment, and the Role of Modern Educational Tools hypospadias pediatric urology surgical outcomes health services
- New Lab Bench for a Rare Childhood Testicular Cancer2026-01-12
First PDX model for pediatric testicular yolk sac tumor, validated against a 109-patient retrospective series; 91.7% of patients presented at stage I
Establishment and Characterization of a Testicular Yolk Sac Tumor PDX Model testicular cancer pediatric urology animal study surgical outcomes
- One Surgery, Three Days Fewer in Hospital2026-01-09
Same-session bilateral kidney stone surgery cut hospital stays by nearly 3 days with no difference in stone clearance or complication rates across 749 patients
One Session or Two? A Meta-Analysis of Same-Session Versus Staged Bilateral Percutaneous Nephrolithotomy kidney stones meta-analysis surgical outcomes
- Undescended Testes Wreck Fertility in Several Ways2026-01-09
A review maps the biological pathways from undescended testes to infertility — temperature, hormones, oxidative stress, and autoimmunity
Cryptorchidism and Infertility: What Do We Know So Far? male infertility cryptorchidism
- Vitality Shields Diabetic Women from Sexual Dysfunction2026-01-08
Postmenopausal women with T2D had worse sexual function and quality of life — age raised FSD odds, but higher vitality reduced them.
Sexual Dysfunction and Quality of Life in Postmenopausal Type 2 Diabetes: Clinical and Laboratory Factors diabetes menopause sexual dysfunction quality of life cross-sectional women's health cardiovascular disease
- 55 Men, OR of 21 — Color Me Skeptical2026-01-07
An enzyme involved in oxidative stress showed lower activity in infertile men — in a study of 55 total subjects
Enzymatic and Genetic Evaluation of Butyrylcholinesterase in Male Infertility male infertility genetics oxidative stress biomarkers case-control study
- Penile-Implant Review Written By Its Sellers2026-01-06
Three of seven authors on this penile nerve-implant review work for the company selling the device
Implantable pelvic neurostimulators to restore erectile function: from concept to practice erectile dysfunction spinal cord injury narrative review neurostimulation
- 39% of Women in Primary Care Have Sexual Dysfunction2026-01-06
39% prevalence of female sexual dysfunction in primary care — but the evidence base is five years stale
Female Sexual Dysfunction in Primary Care: A Systematic Review and Meta-Analysis of Prevalence sexual dysfunction meta-analysis evidence quality
- Two Genes Predict Penile Cancer Outcomes2026-01-05
A 2026 pathologist-facing review codifies how HPV status and TP53 mutations should shape penile cancer prognosis
Select Updates in Pathology of Kidney, Testis, and Penile Cancer for 2026 penile cancer testicular cancer kidney cancer pathology
- New Blood Marker Flags ED — At 71% Accuracy2026-01-05
sTWEAK, an inflammatory cytokine, rose with ED severity in 90 patients vs. 90 controls — AUC 0.776, 71% sensitivity and specificity
New biomarker for erectile dysfunction: Soluble tumor necrosis factor-like weak inducer of apoptosis erectile dysfunction biomarkers vascular health cardiovascular disease
- Better Sperm Quality, Still Not Pregnant2026-01-05
Treating seminal tract infections improves sperm parameters and reduces DNA fragmentation — but no evidence shows it increases conception rates
Infection and Inflammation of the Seminal Tract: A Review of Its Relationship to Male Fertility male infertility semen quality DNA fragmentation inflammation
- Genetic Testing Solves Only 1 in 13 Infertility Cases2026-01-03
India's largest male infertility genomics cohort found a genetic cause in just 7.7% of 247 men with severe sperm defects
Genetic Diversity of Infertile Males in India genetics male infertility spermatogenesis infertility
- Three Specialties Finally Agree on Low T2026
Brazil's three major societies align on hypogonadism diagnosis and TRT — first multidisciplinary consensus for the country
Care of Patients with Male Hypogonadism: A Joint Position Statement from SBEM, SBU, and ABEMSS hypogonadism testosterone therapy metabolic syndrome obesity
- Antioxidants Out, Varicocele Repair In: WHO Rules2026
WHO's first unified infertility guideline backs varicocele repair conditionally but won't endorse antioxidants—evidence too heterogeneous
The WHO 2025 Guideline for the Prevention, Diagnosis and Treatment of Infertility: A Comprehensive Review with Focus on Male Reproductive Health male infertility infertility evidence quality semen quality
- Surgery for Micropenis: Evidence Too Thin to Recommend2026
Narrative review of 36 studies: early testosterone therapy beats surgery for micropenis, but RCT data barely exists
Micropenis in Children and Adolescents: A Narrative Review hypogonadism testosterone therapy evidence quality pediatric urology
- Semen Vesicles May Diagnose Infertility2025-12-31
Seminal exosomes carry RNA that may help diagnose male infertility — but this review is thin on specifics
Exosomal ncRNAs in Seminal Fluid: Unraveling Their Regulatory Roles in Male Infertility male infertility biomarkers
- Asthma Hurts Women's Sex Life, Not Marriage2025-12-31
80 asthmatic women scored worse on sexual function and sexual quality of life than matched controls, but marital adjustment scores were similar
Does Asthma Affect Women's Sexual Life and Marital Adjustment? case-control study cross-sectional sexual dysfunction women's health
- Only 12% of Men Satisfied With Surgical Appearance2025-12-26
Only 12% of men with repaired bladder exstrophy were satisfied with genital appearance; 43% of women met criteria for sexual dysfunction
Long-term Sexual Outcomes in Classic Bladder Exstrophy: Insights from Standardized Scores bladder exstrophy pediatric urology sexual dysfunction erectile dysfunction surgical outcomes patient satisfaction retrospective cohort quality of life
- Testosterone Review Skips the Hard Evidence2025-12-24
A non-systematic review says testosterone therapy is safe and effective, but cites no funding or conflicts
Testosterone Therapy in Adult Males with Hypogonadism testosterone therapy hypogonadism narrative review evidence quality
- EAU Panel: Varicocele Surgery for Azoospermia? Evidence Too Weak2025-12-23
EAU guidelines panel finds the evidence for varicocele surgery in nonobstructive azoospermia too weak to support a strong recommendation
Varicocele Treatment in Azoospermia Before Artificial Reproductive Techniques: Critical Considerations by the EAU Guidelines Panel on Sexual and Reproductive Health varicocele male infertility evidence quality narrative review
- Vascular Surgery's Sexual Side Effects: Nobody's Talking2025-12-20
88% of male AAA patients were never warned their procedure could affect sexual function—yet it did
Sexual Function Following Elective Endovascular Surgery for Abdominal Aortic Aneurysm surgical outcomes sexual dysfunction vascular health women's health
- Blood Type O and Infertility: Weak Signal, Big Caveats2025-12-19
Blood type O was overrepresented in infertile couples (39.5% vs 34.2%), but effect sizes were weak and key findings didn't survive correction
ABO Blood Group Distribution and Infertility Risk in Southern China: A Retrospective Analysis of the Ganzhou Region male infertility infertility genetics semen quality
- Sexual Problems Drive Dissatisfaction — Not Vice Versa2025-12-18
Sexual problems at baseline predicted lower satisfaction 2 years later, but satisfaction did not predict future problems — a one-way street in 83 couples
The Interrelationships Between Sexual Problems and Sexual Satisfaction: A Two-Year Longitudinal Study with Dyads sexual dysfunction quality of life longitudinal study relationship health
- When Pelvic Floor Therapy Conflicts With Trauma2025-12-17
~15% of French women report lifetime sexual violence; this review flags intravaginal PT as a trauma conflict for pelvic pain patients
Pelvic Floor Physical Therapy for Sexual Abuse Survivors With Pelvic Pain pelvic floor women's health sexual dysfunction narrative review vaginismus
- This Review Skipped Its Own Quality Check2025-12-17
A 30-year literature review on sexual dysfunction after cancer treatment applied no formal quality screen to the studies it included
Strategies for Treating Sexual Health Concerns After Breast and Gynecologic Cancer cancer survivors sexual dysfunction menopause narrative review
- Blocking One Protein Protects Penile Vessels in Diabetic Rats2025-12-16
Rat study identifies a molecular pathway linking high blood sugar to penile endothelial aging — no human data yet
Inhibition of c-Jun/Bak Signaling Alleviates Endothelial Cell Senescence and Inflammation Caused by Mitochondrial Dysfunction in DMED erectile dysfunction animal study oxidative stress vascular health inflammation
- Rare Ovarian Tumor: DICER1 in Every Case2025-12-15
In 11 cases of this exceptionally rare ovarian tumor type, 100% harbored DICER1 mutations and 86% carried double mutations, pointing to DICER1 as the primary driver.
Ovarian Sertoli-Leydig Cell Tumors with Heterologous Rhabdomyosarcoma: Clinicopathologic Features and Molecular Analysis Highlighting Recurrent Genetic Alterations pathology genetics women's health
- Kidney Stone Tool Use Varies 24-Fold; Infections Don't2025-12-15
UAS used in 59% of kidney stone surgeries, but practice rates range from 4% to 99%—and 30-day infection hospitalizations are the same either way
Ureteral Access Sheath Use and Infection-Related Hospitalizations: Practice Patterns and Outcomes kidney stones surgical outcomes health services
- Ancient TCM Formula Targets Copper-Mediated Sperm Death2025-12-13
A rat study found Zuogui Wan improved sperm quality partly by reducing testicular copper accumulation and suppressing cuproptosis
Research on the Mechanism of Zuogui Wan in Ameliorating Oligoasthenozoospermia in Rats via Modulating Cuproptosis-Related Pathways animal study male infertility spermatogenesis traditional chinese medicine oxidative stress
- Labiaplasty Scores Better Sex on Paper2025-12-13
Pooled data from 6 studies show a moderate FSFI improvement (SMD 0.52) after labiaplasty, but low certainty undermines the finding
Sexual Function After Female Genital Cosmetic Surgery: A Systematic Review and Meta-Analysis meta-analysis surgical outcomes sexual dysfunction women's health evidence quality
- Microplastics Rival Chemo for Sperm Damage in Rats2025-12-05
Network meta-analysis of 201 rodent studies ranks microplastics alongside chemotherapy drugs for reproductive toxicity, with sperm counts dropping to ~19 million/mL
Quantitative Analysis and Toxicological Mechanisms of Various Male Infertility Inducers: A Network Meta-Analysis and Pharmacological Approach male infertility meta-analysis environmental exposure semen quality
- Doing Both Kidneys at Once: 75% Stone-Free2025-12-04
Egyptian retrospective study of 52 patients found a 75% primary stone-free rate for simultaneous bilateral kidney stone removal in one supine session
Single-Session Bilateral Supine Percutaneous Nephrolithotomy: Safety and Efficacy kidney stones surgical outcomes
- Painful Sex Tops QoL Concerns in Endometriosis2025-12-03
Dyspareunia was the dominant sexual dysfunction in 1,586 French endometriosis patients; the QoL-sex link disappeared in obese and low-education subgroups
Sexual Functioning and Quality of Life Among Women With Endometriosis: A French Cross-Sectional Survey cross-sectional sexual dysfunction women's health
- The Test Your Fertility Clinic Isn't Running2025-12-03
A narrative review arguing that histone modifications in sperm—disrupted by toxicants and lifestyle—may explain a large share of "unexplained" infertility cases.
Epigenetic Dysregulation in Idiopathic Male Infertility: The Role of Aberrant Histone Post-Translational Modifications epigenetics male infertility environmental exposure oxidative stress spermatogenesis
- Obesity and ED: 23 Studies, Still No Clear Answer2025-12-03
23 studies, 52,981 men — and researchers still can't agree on how common ED is in obese men
Prevalence and Incidence of Erectile Dysfunction in Men With Overweight and Obesity: A Systematic Literature Review erectile dysfunction obesity systematic review metabolic syndrome
- Is Air Pollution Killing Your Sperm?2025-12-01
A Chinese review synthesizes evidence that fine particulate matter damages male fertility through oxidative stress and hormone disruption
The Silent Threat: PM2.5-Associated Challenges in Male Reproductive Health male infertility air pollution
- PET Scans Outperform CT for Penile Cancer Staging2025-11-29
Review finds FDG PET/CT beats conventional imaging for lymph node staging in penile cancer, though evidence base remains limited.
The Value of FDG PET/CT in Penile Cancer: An Update penile cancer biomarkers surgical outcomes evidence quality
- Mice Missing CFAP77 Are Subfertile, Not Sterile2025-11-29
Mice engineered to lack a sperm tail protein called CFAP77 had sluggish sperm and fewer pups, but weren't infertile
Microtubule Inner Protein CFAP77 Contributes to Sperm Motility and Male Fertility in Mice male infertility animal study spermatogenesis genetics
- Herbal Skin Patch Protects Rat Sperm from Plasticizer2025-11-28
In rats exposed to DEHP plasticizer, icariin microneedle patches reduced testicular damage and outperformed oral icariin — in rats
Transdermal Delivery of Icariin via Microneedle Patches Attenuates Phthalate-Induced Testicular Injury animal study male infertility traditional chinese medicine environmental exposure
- Obesity Wrecks Fertility in Both Sexes2025-11-27
Narrative review of how adiposity impairs reproduction — admits the fix is unclear
Obesity and Infertility: A Double Whammy infertility obesity
- Intraoperative Biopsy Saved 81 Testes From Unnecessary Removal2025-11-20
Frozen section biopsy correctly identified 58% of small testicular masses as benign, sparing those patients radical orchidectomy — with zero false negatives across 135 cases.
Testicular Mass Frozen Section Examination: Pathological Insights and Diagnostic Accuracy testicular cancer testicular disease surgical outcomes pathology
- Penile Cancer Staging Overtreats 80% of Patients2025-11-20
Review argues current DSNB guidelines trigger full lymph node dissection in over 80% of men who wouldn't benefit from it
Sentinel Node Mapping in Penile Cancer: An Update on Methods and Pitfalls penile cancer surgical outcomes evidence quality biomarkers
- Three Guidelines on Penile Cancer Can't Agree2025-11-19
Three major oncology guideline bodies disagree on lymph node staging and treatment in penile cancer, leaving surgeons without consensus at every decision point.
Penile Cancer and Lymph Node Management: A Call for Standardization penile cancer surgical outcomes narrative review evidence quality
- Sildenafil Beats Tadalafil—But Read the Fine Print2025-11-19
Sildenafil scored higher than tadalafil on satisfaction and hardness in 132,100 real-world patients; vardenafil had the worst side-effect profile (47.4% vs ~34%).
Head-to-head Comparison of the Safety and Efficacy Profiles of Three Phosphodiesterase Type 5 Inhibitors through Patient-reported Outcomes of 130 000 Patients from a Direct-to-consumer Platform Database erectile dysfunction pharmacovigilance health services evidence quality
- Gut Metabolite Cuts Kidney Stone Damage—in Mice2025-11-19
A pomegranate-derived gut metabolite reduced kidney crystal deposits in mice by reactivating a mitochondrial cleanup pathway via PCK1
Urolithin A Protects Against Calcium Oxalate-Induced Crystal Formation and Kidney Injury by Regulating PCK1 to Restore Mitophagy Function in Kidney Stone Disease kidney stones animal study
- When the "Tumor" Was Just Misplaced Spleen2025-11-17
A 10-year-old's para-testicular "tumors" turned out to be ectopic splenic tissue — a rare anomaly that can prevent unnecessary surgery if recognized
An Unexpected Bond: Unraveling a Case of Spleno-Gonadal Fusion Anomaly Mistaken for Lymph Node and Testicular Tumor case report cryptorchidism pediatric urology testicular disease pathology
- Two Brothers, One Gene, Zero Sperm Motility2025-11-11
Two siblings share novel homozygous DNHD1 mutations causing severe flagellar defects and near-total sperm immotility
Novel Biallelic *DNHD1* Variants Associated with Male Infertility with Severe MMAF Phenotype genetics male infertility semen quality case report
- Sperm's "Power Plant" Role Has Been Overstated2025-11-11
The textbook model of sperm energy production — mitochondria fuel the tail — is more complicated than it looked
Sperm mitochondrial sheath formation - how and why? male infertility spermatogenesis narrative review infertility
- Ureaplasma Hits Sperm DNA Without Tanking the Count2025-11-11
UU infection correlated with higher DNA fragmentation index and more abnormal morphology, but most routine semen parameters were unchanged
Effects of Ureaplasma urealyticum Infection on Sperm DNA and Semen Quality male infertility semen quality infertility biomarkers
- Venlafaxine Nearly Doubles Sexual Dysfunction Risk in Depressed Men2025-11-08
Venlafaxine raised sexual dysfunction risk 27% vs citalopram overall — and 93% higher among hospitalized depression patients
Sexual Dysfunction in Male Patients After Initiating Treatment with Antidepressants antidepressants sexual dysfunction pharmacovigilance cohort study
- Two Implants at Once After Prostatectomy: Small Trials, Decent Numbers2025-11-07
Simultaneous penile prosthesis + incontinence device implantation appears safe, with continence rates of 72–100% and IPP satisfaction of 84–100% — but all 21 included studies are small and mostly retrospective
Surgical Treatment Options for Concomitant Post-Prostatectomy ED and Stress Urinary Incontinence erectile dysfunction penile prosthesis surgical outcomes prostate cancer
- Uterus in Males: A Hidden Infertility Cause2025-11-07
Only 1 in 5 men with PMDS have conceived naturally at time of diagnosis; most present with cryptorchidism or hernias
Persistent Müllerian Duct Syndrome - A Rare but Important Cause of Male Factor Infertility cryptorchidism male infertility narrative review pediatric urology
- Suction Scopes Look Promising, Evidence Still Thin2025-11-06
Systematic review of 35 studies finds suction-assisted ureteroscopy improves stone clearance and cuts infection risk, but high-quality evidence is scarce.
Complication Rates and Outcomes of Suction Devices in Ureteroscopy and Retrograde Intrarenal Surgery: A Systematic Review kidney stones evidence quality
- Chinese Herbal Mix Reverses Rat Infertility2025-10-31
TCM formula QYYJF improved sperm motility and HPG axis hormones in chemotherapy-damaged rats, via 25 identified serum compounds
Qingyu Yangjing Formula Ameliorates Cyclophosphamide-Induced Oligoasthenospermia by Regulating the Hypothalamic-Pituitary-Gonadal Axis and Inhibiting Testicular Oxidative Stress and Apoptosis in Rats traditional chinese medicine male infertility animal study semen quality
- Prone PCNL: Same Stones Cleared, More Complications2025-10-29
Prone positioning matched supine for stone clearance (85% vs 81%) but had higher rates of blood transfusion, renal pelvic perforation, and pneumothorax
Comparison of Prone and Supine Positions for Suction Mini-PCNL kidney stones surgical outcomes
- Swapping One Protein Rescues Infertile Mouse Sperm Cells2025-10-28
Deleting a common protein-recycling complex stops sperm cell development in mice — swapping in a related complex fixes it
The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice male infertility spermatogenesis animal study genetics
- A Blood Test May Soon Detect Testicular Cancer2025-10-22
miR-371a-3p is approaching clinical use as a noninvasive diagnostic marker for testicular germ cell tumors
Testicular Germ Cell Tumors and Molecular Biomarkers testicular cancer biomarkers
- High-Volume Exercise Linked to Bladder Leaks in Men2025-10-21
Scoping review of 10 studies finds LUTS rates up to 18.8% in male athletes, with a strong dose-response correlation (R = 0.87) between weekly exercise volume and urinary symptoms.
Prevalence of Pelvic Floor Dysfunction in Male Athletes and Its Dose-Dependency in High-Intensity Exercise: A Scoping Review erectile dysfunction evidence quality cross-sectional pelvic floor
- TCM Formula Improves Sperm in Fat Mice2025-10-16
A traditional Chinese herbal formula reduced abnormal sperm and boosted concentration in obese mice — in mice only
Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1/p53 axis male infertility traditional chinese medicine animal study
- Nanoparticles Sneak ATP Past the Testicular Wall2025-10-13
ATP-loaded nanoparticles crossed the testicular barrier in mice and improved sperm motility — no human data yet
Blood-Testis Barrier-Crossing Extracellular Vesicles for Asthenozoospermia Therapy via Synergistic ATP Replenishment and Ferroptosis Suppression male infertility spermatogenesis stem cells oxidative stress animal study
- Testicular Cancer Is Getting Older and Surviving Better2025-10-13
30-year Spanish single-center data: men over 40 at diagnosis quadrupled from 7% to 29%, and 10-year cause-specific survival reached 97%
Epidemiological Patterns, Temporal Trends in Management and Long-Term Outcomes in Testicular Cancer: a 30-Year Single Center Experience testicular cancer survivorship cohort study health services
- Kidney Stones as an Existential Crisis2025-10-10
Philosophers and urologists team up to argue kidney stones aren't just a medical problem — they're an existential one
Kidney Stone Disease: Phenomenological Perspectives kidney stones
- CoQ10 Cuts Varicocele Damage — In Rats2025-10-07
CoQ10 reduced oxidative stress and improved sperm parameters in rat varicocele and hypoxia models via the caspase1-IL1β-egr2 pathway
Ameliorative Effects of Coenzyme Q10 Against Hypoxia-Induced and Varicocele-Associated Spermatogenesis Dysfunction in Rat animal study male infertility semen quality testicular disease
- No Trials Yet, So Chemo Still Wins2025-10-01
A cancer so rare its "standard" chemo regimen has never been tested against newer immunotherapy in a randomized trial
An update on the pharmacotherapy of penile cancer penile cancer narrative review immunology evidence quality
- GLP-1 Drugs and Sperm: Mostly Rat Data So Far2025-09-26
Ozempic-class drugs may help sperm in obese men, but most of the evidence so far is from rats
Impact of GLP-1 Receptor Agonists on Male Fertility: Emerging Evidence and Future Directions obesity diabetes hypogonadism spermatogenesis animal study narrative review
- Testicular Cancer Rehab: Big Claims, Thin Evidence2025-09-22
A review urging exercise and psych support for testicular cancer survivors despite admitting the evidence base is sparse
Exercise, diet and psychological support for patients with testicular cancer. testicular cancer survivorship
- Surgically Retrieved Sperm Drags Down IVF Success2025-09-20
Testicular sperm extraction cut live birth rates vs. ejaculated sperm in ICSI — but only cumulative, not first-transfer outcomes
Effect of Abnormal Semen Parameters on ICSI: Morphokinetics and Cumulative Clinical Outcomes of 10,623 Embryos male infertility semen quality infertility surgical outcomes
- Two Cases, One Broken Flagella Gene2025-09-19
Whole-exome sequencing in two infertile men pinpoints new FSIP2 mutations that gut sperm flagella structure
Novel mutations in FSIP2 cause male infertility through multiple morphological abnormalities of the sperm flagella male infertility genetics
- A Puberty Gene Discovery Now Treats Hot Flashes2025-09-17
Over 60 genes are now linked to a puberty-blocking disorder, but genetics still explains only half of cases
Genetics of Idiopathic Hypogonadotropic Hypogonadism genetics hypogonadism male infertility narrative review
- A $165 to $101,510 Gap for the Same Surgery2025-09-15
The same kidney stone operation (PCNL) costs anywhere from $165 to $101,510 depending on where it's done — a 615-fold gap that makes cost comparisons nearly meaningless
Costs of Resolving a Ureteral or Kidney Stone Episode Worldwide: A Systematic Review kidney stones health services systematic review surgical outcomes
- Mutant DNA Repair Gene Found in Two Infertile Men2025-09-15
Two men with severe OAT carried novel loss-of-function variants in MDC1, a DNA damage checkpoint protein — one ICSI attempt failed
Novel Variants in MDC1 are Associated With Severe Oligoasthenoteratozoospermia genetics male infertility semen quality case report
- One New Implant Fails 1 in 4 Times2025-09-13
Across 30 studies, penile implant removal rates were generally below 10%, but one newer device (Zephyr ZSI 475®) showed a 25.7% early mechanical failure rate.
Removal Rate and Mechanical Failure in Penile Prosthesis Implantation: A Systematic Review penile prosthesis erectile dysfunction surgical outcomes evidence quality
- Vaginal Dryness Correlates With Higher Sexual Interest — Somehow2025-09-10
195 postmenopausal Turkish women: pain during sex lowered sexual interest; vaginal dryness paradoxically correlated with higher interest
The Association Between Day-to-Day Impact of Vaginal Aging and Female Sexual Function menopause sexual dysfunction women's health cross-sectional
- Suction Access Nearly Doubles Stone Clearance Odds2025-08-29
Vacuum-assisted mini-PCNL cleared stones at nearly twice the rate of conventional sheaths across 14 studies and 2,510 patients
Suction in Mini-Percutaneous Nephrolithotomy: A Meta-Analysis from the European Association of Urology Section of Endourology kidney stones meta-analysis
- Smaller Kidney Stone Scope, Same Results, Fewer Complications2025-08-29
UM-PCNL cleared stones as effectively as standard PCNL in 628 patients but with fewer complications and shorter hospital stays.
Comparative Efficacy and Safety of Ultra-Mini-Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy for Renal Calculi: A Systematic Review and Meta-Analysis kidney stones meta-analysis evidence quality
- Counseling Beats Silence for Pregnant Women's Sexual Function2025-08-27
Three counseling approaches improved sexual function scores in pregnant women — but 21 of 24 studies came from Iran
Non-pharmacologic therapies for treating sexual dysfunction during pregnancy: A systematic review and meta-analysis sexual dysfunction pregnancy
- The Vote That Ended PeIN Grading2025-08-20
112 pathologists surveyed on how to classify penile precancer; 82% ultimately voted to abandon grading after starting nearly split 51/49
International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 Report on Terminology, Grading, and Molecular Testing Practices penile cancer HPV pathology biomarkers
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- Does Your Gut Decide If a PE Drug Works?2025-07-22
Men who responded to dapoxetine had different gut bacteria than non-responders, but the link was weak
Uncovering novel therapeutic targets for premature ejaculation from gut microbiota: A prospective high-throughput sequencing study premature ejaculation gut microbiome biomarkers cohort study
- Nine Societies, No Consensus on Low Testosterone2025-07-19
Nine major specialist societies disagree on the name, diagnostic cutoffs, and monitoring protocols for male hypogonadism
Variations in Diagnostic Criteria for Male Hypogonadism: Is There a Need for Standardizing Specialist Society Guidelines? hypogonadism testosterone narrative review evidence quality
- Stone Patients Rate Their Pain 7 Out of 102025-07-15
44 UK stone patients rated QoL impact at median 7/10; 82% would take prophylactic medication, but no prevention drug yet has high-quality evidence behind it.
Patients' priorities in kidney stone disease kidney stones evidence quality surgical outcomes cross-sectional
- Older Mothers, More Severe Hypospadias: Small Study2025-07-15
Boys with hypospadias had shorter anogenital distance (4.64 vs 5.33 cm); maternal age ≥34 correlated with severe cases
Genetic Susceptibility and Pathogenesis of Hypospadias hypospadias pediatric urology case-control study genetics
- A New Heart Helps Your Sex Life. A New Pancreas Doesn't.2025-07-08
Transplantation linked to a 2.11% absolute drop in coded sexual dysfunction in men — statistically real, clinically modest
The Impact of Solid Organ Transplantation on Sexual Dysfunction and Infertility in Older Men and Women: A Claims-Based Study sexual dysfunction erectile dysfunction infertility retrospective cohort health services surgical outcomes
- A Rare Penile Condition With Almost No Research2025-07-07
Only 8 studies exist on hard-flaccid syndrome — most are case reports, leaving diagnosis and treatment without any established guidelines.
Hard-Flaccid Syndrome: A Systematic Review of Aetiopathophysiology, Clinical Presentation and Management erectile dysfunction sexual dysfunction systematic review pelvic floor case report
- Breast Cancer's Sexual Side Effects: Still Mostly Ignored2025-07-04
92% of breast cancer patients wanted systematic sexual health information; only 47% ever got any, and just 20% were screened
Information and Screening for Sexual Disorders of Patients with Non-Metastatic Breast Cancer: Results of a Survey sexual dysfunction screening survivorship women's health health services cross-sectional
- Sexual Self-Esteem Tracks Closely With ED and PE2025-07-04
In 5,665 German men at age 50, negative body image, low sexual self-esteem, and perceived sexual pressure each independently predicted ED, PE, and low libido (all p<0.001)
Dimensions of Sexual Self-Concept and Sexual Dysfunctions in Middle-Aged Men: Results of the Bavarian Men's Health Study erectile dysfunction sexual dysfunction cross-sectional epidemiology
- 18 'Male Fertility Genes' Turn Out Unnecessary2025-06-26
18 testis-enriched genes knocked out one by one in mice — none of them mattered for fertility
Mouse Genome Engineering Uncovers 18 Genes Dispensable for Male Reproduction animal study genetics male infertility semen quality
- Genetics Flags Two New ED Drug Targets2025-06-15
Mendelian randomization across ~325K individuals flagged two candidate drug targets for ED, both expressed in penile endothelial and smooth muscle cells
Identification of potential drug targets for erectile dysfunction with single-cell RNA sequencing: A Mendelian randomization study erectile dysfunction genetics vascular health biomarkers
- A Boy's Rare Mutation, Recreated in Mice2025-06-03
One boy's gene mutation was knocked into mice, who developed undescended testes and poor sperm quality
Cryptorchidism: Novel genetic insights into CCDC149 mutations cryptorchidism genetics animal study case report
- Sickle Cell Damages Sperm — So Does the Treatment2025-05-30
Systematic review finds SCD impairs sperm parameters, and both hydroxyurea and stem cell transplant make it worse
Reproductive function and sperm parameters in men with sickle cell disease: a systematic review male infertility semen quality genetics stem cells
- Herbal Capsule Tackles BPH and ED Together in Rats2025-05-27
A Chinese herbal capsule eased both prostate enlargement and erectile dysfunction in rats—finasteride only fixed one
Intervention of Bazi Bushen Capsule on Benign Prostatic Hyperplasia Concomitant with Erectile Dysfunction Induced by Testosterone Supplementation in Spontaneously Hypertensive Rats BPH erectile dysfunction traditional chinese medicine animal study inflammation
- Stone Formers' Own Urine Grows More Stones2025-05-23
Urine proteins from calcium oxalate stone patients actively promote crystal formation in vitro, while healthy urine proteins inhibit it — with ~2.5x more oxidized proteins driving the difference.
Urinary Proteins from Stone Formers Promote Calcium Oxalate Crystallization, Growth and Aggregation via Oxidative Modifications kidney stones biomarkers oxidative stress
- Mom's Obesity Linked to Son's Low Testosterone2025-05-14
Men whose mothers were obese during pregnancy had 5.9× higher odds of low testosterone — but only 12 of 418 men had that history
Low testosterone in primary infertile men is associated with a history of maternal obesity during pregnancy: Findings from a cross-sectional study. male infertility testosterone obesity pregnancy hypogonadism
- FSH Pharmacogenetics: Interesting Science, Unusable Data2025-04-30
Genetic variants in FSH and its receptor affect sperm production, but current evidence is too small and contradictory for clinical use
Pharmacogenetics of Follicle-Stimulating Hormone Action in the Male male infertility genetics infertility narrative review spermatogenesis
- Glans Removal Outcomes Look Good — If You Squint2025-04-15
14 studies, 327 procedures: 91% retained erectile function after glansectomy, but outcome reporting was too inconsistent to draw firm conclusions
Functional Outcomes of Glansectomy to Treat Localised Penile Cancer: A Systematic Review penile cancer surgical outcomes sexual dysfunction evidence quality
- hCG for Azoospermia: Settled Science for One Type, Guesswork for the Rest2025-02-04
A narrative review argues hCG may treat more azoospermia subtypes than currently accepted, introducing the unvalidated "APHRODITE criteria" to guide patient selection.
Human Chorionic Gonadotropin-Based Clinical Treatments for Infertile Men with Non-Obstructive Azoospermia male infertility spermatogenesis hypogonadism narrative review
- One Hormone Test to Find Where Hypogonadism Starts2025-01-20
A narrative review proposes kisspeptin stimulation as the first viable way to tell whether low testosterone originates in the hypothalamus or pituitary.
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders. hypogonadism narrative review biomarkers infertility testosterone
- After Hirschsprung Surgery, the Bowel Predicts ED2024-12-23
Nordic men who had pull-through surgery for Hirschsprung disease reported 12.7% failure to conceive — below the WHO population estimate of 16.5%
Fertility and Sexual Function in Males With Hirschsprung Disease: A Nordic Cross-sectional Study cross-sectional erectile dysfunction male infertility pediatric urology surgical outcomes quality of life
- Massive Genital Swelling: No Protocol Exists2024-12-04
No evidence-based treatment protocol exists for penoscrotal elephantiasis, a rare lymphatic condition causing irreversible penile and scrotal swelling
Operative Management of Penoscrotal Elephantiasis narrative review surgical outcomes inflammation pathology
- A Penile Erection Lasting 4+ Hours Is an Emergency in Kids Too2024-11-25
Sickle cell disease is the leading cause of priapism in boys, and delayed treatment risks permanent erectile dysfunction
Priapism in the paediatric and adolescent population pediatric urology priapism erectile dysfunction narrative review
- Robotic Surgery Halves Ejaculation Problems After Rectal Cancer2024-10-22
Robotic rectal surgery cut ejaculatory dysfunction from 41% to 25% vs. laparoscopic at 12 months — no edge on erections
Prospective Multicenter Comprehensive Survey on Male Sexual Dysfunction following Laparoscopic, Robotic, and Transanal Approaches for Rectal Cancer (the LANDMARC Study) surgical outcomes erectile dysfunction sexual dysfunction robotics quality of life
- Four Patients, Three Conflicts, One Recommendation2024-03-05
A 4-patient case series — with manufacturer financial ties declared by 3 of 5 authors — reports high satisfaction with a subcutaneous silicone penile implant post-prostatectomy.
Himplant® Subcutaneous Penile Implant Improves Penile Appearance and Erectile Dysfunction After Radical Prostatectomy: A Case Series penile prosthesis erectile dysfunction prostate cancer case report