← all papers · testosterone (25) Science journalism, not medical advice.
- Low T From Stress Isn't Broken Testicles2026-07-15
Military and athlete studies suggest stress-related low testosterone is often reversible brain signaling, not testicular failure
Stress-associated testosterone suppression: central adaptation or hypogonadism? testosterone hypogonadism narrative review stress exercise
- Skip Leg Day, Hurt Your Fertility?2026-07-11
A narrative review argues weak muscles and low testosterone track with worse sperm quality, but cites no new data of its own
Male fertility as an integral reflection of metabolic, endocrine, and musculoskeletal health male infertility narrative review testosterone exercise
- Most Low Testosterone Is Just Obesity2026-06-23
JAMA review puts obesity-driven low T (2–8% prevalence) well ahead of true gonadal failure (<1%), with weight loss as first-line.
Adult Male Hypogonadism: A Review hypogonadism testosterone obesity testosterone therapy narrative review
- One Testosterone Test Isn't Enough for ED2026-06-16
Lab review argues most ED workups over-order hormones and under-order glucose and lipids
High-value laboratory testing in erectile dysfunction, reduced sexual desire, and suspected hypogonadism: analytical pitfalls and selective biomarker use erectile dysfunction hypogonadism testosterone biomarkers narrative review
- Weight Loss Surgery Improved Sperm Quality — No Pregnancies Followed2026-05-23
43 obese infertile men saw testosterone rise and semen motility improve after bariatric surgery — but zero pregnancies in 12 months
The Influence of Different Bariatric Surgeries on Male Sex Hormones and Semen Parameters Among Infertile Obese Male Patients: An Observational Study male infertility obesity testosterone semen quality surgical outcomes
- Gut Bacteria May Hurt Sperm. The Evidence Is Thin.2026-05-16
A plausible gut-testis axis linking dysbiosis to poor sperm quality — authors themselves admit few human studies back it up
Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions gut microbiome male infertility spermatogenesis narrative review testosterone inflammation
- Testosterone Therapy May Raise Fracture Risk2026-05-16
TRAVERSE trial found higher fracture rates in men randomized to testosterone — a result the review calls "unexpected"
Testosterone and Bone Health in Men testosterone testosterone therapy hypogonadism evidence quality
- One Editorial, No New Data on Varicocele2026-05-12
A leading infertility surgeon's editorial preview of a themed issue, containing no original data of its own
Varicocele: new perspectives on an old problem varicocele male infertility narrative review testosterone
- Melatonin for Low Testosterone: Interesting Theory, No Trials2026-05
Chinese TCM researchers propose melatonin could restore endogenous testosterone by repairing aging Leydig cells — supported by animal data and zero LOH clinical trials
From "Passive Supplementation" to "Active Repair": Melatonin Reshapes the Treatment Paradigm for Late-Onset Hypogonadism by Targeting Leydig Cell Senescence hypogonadism testosterone oxidative stress narrative review traditional chinese medicine
- Can Metformin Treat Male Infertility?2026-04-29
Review argues AMPK—an energy-sensing enzyme disrupted by obesity and diabetes—could be a druggable target for male infertility
Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies male infertility metabolic syndrome spermatogenesis narrative review oxidative stress testosterone
- Hypospadias Hints at Hidden Testicular Problems2026-04-22
113 Danish infants with hypospadias showed reduced Sertoli and Leydig cell markers during minipuberty, regardless of defect severity
Reproductive Hormones During Minipuberty Suggest Subtle Testicular Impairments in Boys With Hypospadias hypospadias pediatric urology testosterone biomarkers
- Severe Sleep Apnea Suppresses Testosterone in Obese Men2026-04-22
62% of severely obese male inpatients had low testosterone; severe sleep apnea was an independent predictor, and CPAP raised T after 3 months in 14 men
The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity hypogonadism obesity testosterone cross-sectional
- Vitamin D Improves Sperm, Not Pregnancies2026-04-13
Vitamin D boosted sperm motility by 6.96% and testosterone slightly, but had no measurable effect on pregnancy or live birth rates (n=1,168)
Vitamin D supplementation in infertile men: a systematic review and meta-analysis of effects on semen quality and endocrine function male infertility semen quality testosterone meta-analysis systematic review
- Adding Testosterone Cuts Drug Dose, Not Sperm Rates2026-04-01
Triple therapy (hCG + FSH + testosterone) cut the median hCG dose needed by 17% but didn't significantly improve spermatogenesis rates in 45 CHH men
Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial hypogonadism spermatogenesis testosterone infertility
- Weight Loss Surgery Raises Testosterone — But Not the Free Kind2026-03-25
21 studies, 695 men: bariatric surgery improved IIEF-5 scores by 6.45 points and raised total testosterone, but free testosterone didn't move
The impact of bariatric surgery on male sexual function: a systematic review and meta-analysis obesity erectile dysfunction testosterone meta-analysis systematic review surgical outcomes
- Ginger Improves Sperm in Obese Rats — Humans TBD2026-03-20
Ginger and fenofibrate each reversed obesity-induced sperm and hormone deficits in rats — no human data exists
Effect of Ginger Extract and/or Fenofibrate on the Associated Infertility of Experimentally Induced Obese Wistar Albino Male Rats animal study obesity male infertility oxidative stress spermatogenesis testosterone
- Fixing a Fertility Problem Also Lifts Testosterone2026-03-13
Varicocele repair raised testosterone by 80-100 ng/dL on average, per a review of existing studies
Varicocele and low testosterone varicocele hypogonadism testosterone male infertility narrative review
- Lichen Extract Nearly Triples Sperm Motility — In Rats2026-03-05
Atranorin, a lichen-derived compound, restored sperm motility by 189% and testosterone by 90% in alloxan-diabetic rats at 170 mg/kg.
Extraction, Characterization, and Biological Evaluation of Atranorin Against Diabetes-Induced Reproductive Dysfunction Through Modulation of Oxidative Stress, Inflammatory Pathways and Key Reproductive Enzymes animal study male infertility oxidative stress semen quality testosterone
- Nobody Diagnosed Opioid Hypogonadism. Not Once.2026-02-24
57% of long-term opioid users had at least one hormone disorder; quitting dropped hypogonadism prevalence from 27% to 3%
Endocrinopathies and Their Recovery in a 20-Year Cohort Study of People With Heroin Dependence hypogonadism testosterone mental health longitudinal study opioids
- Inflammation Scores Track With Lower Testosterone2026-02-18
In 7,576 men from NHANES, higher composite inflammation scores independently predicted lower total and free testosterone — but the age-stratified FT findings raise questions
Association Between Chronic Inflammation Status and Serum Testosterone and Free Testosterone in Adult Males cross-sectional testosterone hypogonadism biomarkers inflammation
- Ginseng Compound Raises Testosterone — In Obese Mice2026-01-28
A ginseng-derived compound raised testicular testosterone in high-fat-diet mice by activating the cAMP/PKA/CREB pathway — no human data yet
Ginsenoside Rf Promotes Testosterone Synthesis Through the cAMP/PKA/CREB Signaling Pathway to Improve Obesity-Related Male Hypogonadism animal study hypogonadism testosterone obesity traditional chinese medicine
- Childhood Obesity Shrinks Testicles Before Puberty Starts2026-01-27
Obese prepubertal boys had smaller testicular volume, shorter penis length, and lower testosterone than normal-weight peers in a 60-boy study.
Obesity Impairs Male Reproductive Development in Prepubertal Boys via Local Adipose Tissue Inflammation and the STAT3/CYP19A1 Pathway obesity male infertility testosterone pediatric urology inflammation animal study
- Nine Societies, No Consensus on Low Testosterone2025-07-19
Nine major specialist societies disagree on the name, diagnostic cutoffs, and monitoring protocols for male hypogonadism
Variations in Diagnostic Criteria for Male Hypogonadism: Is There a Need for Standardizing Specialist Society Guidelines? hypogonadism testosterone narrative review evidence quality
- Mom's Obesity Linked to Son's Low Testosterone2025-05-14
Men whose mothers were obese during pregnancy had 5.9× higher odds of low testosterone — but only 12 of 418 men had that history
Low testosterone in primary infertile men is associated with a history of maternal obesity during pregnancy: Findings from a cross-sectional study. male infertility testosterone obesity pregnancy hypogonadism
- One Hormone Test to Find Where Hypogonadism Starts2025-01-20
A narrative review proposes kisspeptin stimulation as the first viable way to tell whether low testosterone originates in the hypothalamus or pituitary.
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders. hypogonadism narrative review biomarkers infertility testosterone