← all papers · biomarkers (47) Science journalism, not medical advice.
- Folate Doesn't Move the Needle on Kidney Stones2026-05-29
Folate intake and circulating folate markers had no significant association with kidney stone disease in 9,208 US adults after adjusting for confounders.
Association Between Dietary and Circulating Folate Markers and Kidney Stones in American Adults: A Cross-Sectional NHANES Analysis kidney stones cross-sectional epidemiology biomarkers
- Immune War in the Testis — Mostly Mouse Data2026-05-12
A review proposes that a shared immune-inflammatory cascade disrupts sperm production — then admits most evidence comes from animals, not men.
Immunological Mechanisms and Precision Stratification in Male Infertility immunology male infertility inflammation oxidative stress narrative review biomarkers spermatogenesis
- Frailty Score Predicts ED—But Only Moderately2026-05-08
Frail men had 22% higher odds of ED vs. non-frail men in a 1,372-person NHANES analysis; predictive accuracy was moderate (AUC 0.662)
Association Between Frailty Index and Erectile Dysfunction: A Cross-Sectional Study Using NHANES 2001 to 2004 Data erectile dysfunction cross-sectional epidemiology biomarkers
- Inside Infertile Sperm: The Missing Power Switch2026-05
In sperm from oligoasthenospermic men, ATP synthase subunits dropped significantly while cytochrome c oxidase rose — in just 17 men
High-Resolution Imaging Reveals Mitochondrial Protein Imbalance in Sperm of Oligoasthenospermic Men male infertility semen quality biomarkers oxidative stress
- Your Genes, Not Your Diet, May Drive Low Phosphate2026-04-30
Narrative review argues that low phosphate in stone formers is driven by genetic defects in kidney transporters, not diet—and that supplementation may cut recurrence.
Hypophosphatemia in Kidney Stone Formers kidney stones genetics narrative review biomarkers
- Five Pregnancy Factors Predict Hypospadias Risk2026-04-27
Five obstetric factors — gestational hypertension, abnormal placenta, and preterm birth among them — predicted hypospadias with AUC 0.857 in temporal validation
Risk Factor Analysis and Nomogram Predictive Model Construction for Neonatal Hypospadias: A Large-Scale Multicenter Study in East China hypospadias pediatric urology pregnancy biomarkers
- Hypospadias Hints at Hidden Testicular Problems2026-04-22
113 Danish infants with hypospadias showed reduced Sertoli and Leydig cell markers during minipuberty, regardless of defect severity
Reproductive Hormones During Minipuberty Suggest Subtle Testicular Impairments in Boys With Hypospadias hypospadias pediatric urology testosterone biomarkers
- Testicular Calcifications Are Only Scary With Baggage2026-04-15
65 studies reviewed: isolated testicular microlithiasis carries minimal cancer risk on its own — the company it keeps is what matters
From Incidentaloma to Actionable Insight: A Clinical-Molecular-Imaging Framework for Risk-Stratified Management of Testicular Microlithiasis testicular cancer testicular disease scoping review biomarkers screening
- Malnutrition Splits Non-Seminoma Survival: 16% vs 97%2026-04-10
Non-seminoma patients with depleted metabolic profiles had 16.1% five-year survival vs 97.4% in those with preserved profiles
Metabolic Profile and Skeletal Muscle as Predictors of Survival in Testicular Germ Cell Tumors testicular cancer biomarkers survivorship cohort study
- Eye Autoimmunity to ED: Pure Speculation2026-04-08
A hypothesis paper proposes that autoimmune retinopathy might damage circadian-regulating retinal cells and thereby impair testosterone and nitric oxide signaling — no data included
A Hypothetical Circadian–Endocrine Pathway Linking Melanopsin-Expressing ipRGC Dysfunction in Autoimmune Retinopathy to Sexual Dysfunction erectile dysfunction sexual dysfunction immunology biomarkers
- Could Infertility Predict Brain Disease? Too Soon to Tell2026-04-02
13-study systematic review finds preliminary mechanistic overlap between male infertility and neurodegeneration — no prospective evidence yet
Male Infertility and Neurodegenerative Diseases: A Systematic Review of Associations and Molecular Mechanisms systematic review male infertility neurodegenerative diseases oxidative stress biomarkers
- Dog Tumor Marker Study Oversells Its Findings2026-03-31
87% of canine testicular seminomas expressed ezrin; higher expression correlated with the more invasive diffuse subtype (n=23)
Histomorphological Features and Ezrin Expression in Testicular Seminomas in Dogs: An Association with Potential Prognostic Value animal study testicular cancer pathology biomarkers
- Four Blood Ratios, Kidney Stones, Mixed Signals2026-03-27
Four composite blood ratios tied to kidney stone prevalence in 27K Americans — but one of the four didn't hold up under scrutiny
Association Between Novel Indicators for Inflammation and Metabolism and Kidney Stones: A Cross-Sectional Analysis of NHANES 2007-2018 kidney stones inflammation biomarkers cross-sectional metabolic syndrome
- Infant Hormone Window Predicts Adult Fertility2026-03-26
Hormone levels at 1–3 months of life predict adult reproductive capacity and can flag hypogonadism before symptoms appear
Clinical Implications of Minipuberty pediatric urology hypogonadism biomarkers infertility
- A Body Measurement Tracks Hypospadias Severity2026-03-21
Boys with hypospadias have shorter anogenital distance (SMD −1.24), with the gap widening as severity increases across 6,905 infants
Association Between Anogenital Distance and Hypospadias: A Systematic Review and Meta-Analysis hypospadias meta-analysis pediatric urology biomarkers environmental exposure
- One Blood Test Stands Out — But Should It?2026-03-19
In 198 Ghanaian ART patients, only serum chloride differed between pregnancy and non-pregnancy groups — a marginal gap within normal range
Male Factors Associated With Success Following Assisted Reproduction Technology Among Infertile Couples in Ghana male infertility semen quality cross-sectional biomarkers pregnancy
- The Testicular Tumor Hiding Behind Wrong Diagnoses2026-03-19
A review of an ultra-rare testicular malignancy, defined by EWSR1::ATF1 gene fusions, that has been routinely misclassified as other tumor types
Inflammatory and Nested Testicular Sex Cord Tumors: Clinical and Molecular Characterization testicular cancer genetics pathology biomarkers
- Male Fertility Prevention: Everything but the Numbers2026-03-18
Narrative review maps primary-to-tertiary prevention in male reproductive health — broad scope, no original data, no quantified effect sizes
Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review male infertility biomarkers infertility screening evidence quality
- FSH, Not Just Testosterone, May Drive Muscle Loss2026-03-17
Men with Klinefelter syndrome had significantly less lean mass than Kallmann men (ALMI 7.28 vs 8.37 kg/m²), implicating FSH
Body Composition by DXA in Patients with Klinefelter and Kallmann Syndrome: The Kama Study hypogonadism testosterone therapy genetics biomarkers
- PE, Anxiety, and SSRIs: One Broken System2026-03-17
A 2026 narrative review maps how serotonin and BDNF link premature ejaculation to comorbid anxiety and depression — and makes a pitch for TCM adjuncts
Role of 5-HT and BDNF in Premature Ejaculation With Anxiety or Depression sexual dysfunction antidepressants traditional chinese medicine biomarkers
- Why Is One-Third of Male Infertility Unexplained?2026-03-14
Male infertility causes 20–30% of all infertility cases globally, yet 30–40% of cases have no identified cause
Epidemiology, Etiopathogenesis, Diagnosis, and Treatment of Male Infertility — Current Trends and Future Directions: A Narrative Review male infertility epigenetics environmental exposure biomarkers
- Mood, Not Birth Method, Drives Postpartum Sexual Dysfunction2026-03-14
Sexual function scores hit a nadir 6–8 weeks postpartum and depression predicted decline better than delivery mode or breastfeeding
Longitudinal Trajectories and Psychosocial Predictors of Postpartum Sexual Dysfunction from Early Pregnancy to 12 Months Postpartum sexual dysfunction women's health pregnancy biomarkers
- Three Metabolic Flags for Silent Heart Damage in ED Men2026-03-09
Dyslipidemia more than doubled the odds of diastolic heart dysfunction in 398 men with ED; BMI was the only factor linking to both types
Risk Factors Associated with Cardiac Dysfunction in Men with Erectile Dysfunction erectile dysfunction cardiovascular disease cross-sectional metabolic syndrome biomarkers
- Poor Sperm, Worse Health: The Iceberg Below2026-03-06
Review argues 1–6% of infertile men have undetected life-threatening pathology, yet workup stops at semen analysis
Is Male Infertility an Early Warning of More Serious Diseases? male infertility genetics semen quality biomarkers
- Old Prostate Exam Survives the MRI Era2026-03-03
A 164-patient retrospective found suspicious DRE was present in 48.5% of clinically significant prostate cancer cases and correlated with advanced pathological stage (≥pT3)
In the Era of mpMRI and PSMA PET/CT: Does Digital Rectal Examination Still Matter? prostate cancer screening retrospective cohort surgical outcomes biomarkers
- The 'We Don't Know' Label Hiding Oxidative Damage2026-03-03
Up to 40% of male infertility is labeled "idiopathic" — this review argues that's a diagnostic failure, not a biological reality
Idiopathic Male Infertility Revisited: Can Redox Endophenotypes Reframe the 'Idiopathic' Label? male infertility oxidative stress biomarkers spermatogenesis
- Mom's Diet Shapes Her Son's Sperm, in Cattle2026-03
Genetics explains only ~15% of male infertility; a cattle review argues epigenetic marks fill the gap — and pass across generations
Bull Fertility and Epigenetics: Exploring Influences Beyond Genetics animal study male infertility genetics epigenetics biomarkers
- AMH Flags Azoospermia But Can't Predict Sperm Count2026-02-20
AMH is lower in men with non-obstructive azoospermia, but doesn't independently predict sperm concentration once FSH and testicular volume are accounted for
Serum Antimüllerian Hormone as a Biomarker of Functional Testicular Reserve: A Comparative Analysis male infertility biomarkers semen quality infertility
- Does Iron Boost Testosterone? Barely2026-02-20
Serum iron associates with testosterone in middle-aged men — but the causal story is murkier than the headline suggests
Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies iron metabolism biomarkers genetics hypogonadism
- Blood Test Predicts Who Survives Salvage Chemo for Testicular Cancer2026-02-19
In relapsed germ cell tumors, a liquid biopsy tumor fraction above threshold predicted significantly worse OS; miR-371a-3p did not.
Impact of Circulating Tumor DNA and Copy-Number Alterations on Clinical Outcome in Relapsed/Refractory Germ Cell Tumors Treated With Salvage High-Dose Chemotherapy testicular cancer biomarkers genomics cohort study
- Inflammation Scores Track With Lower Testosterone2026-02-18
In 7,576 men from NHANES, higher composite inflammation scores independently predicted lower total and free testosterone — but the age-stratified FT findings raise questions
Association Between Chronic Inflammation Status and Serum Testosterone and Free Testosterone in Adult Males cross-sectional testosterone hypogonadism biomarkers inflammation
- Can a Blood Draw Replace Testicular Cancer Imaging?2026-02-11
Rising TGCT incidence, murky risk factors, and two emerging biomarkers — a military urology team surveys the field
Decoding testicular germ cell tumors: integrating risk, biology, and biomarkers into future care testicular cancer biomarkers genetics
- Insulin Resistance Linked to Softer Erections2026-02-11
Higher TyG index — a proxy for insulin resistance — correlated weakly with lower penile rigidity on objective testing (r = −0.22 at best)
Association Between Triglyceride-Glucose Index and AVSS-RigiScan Test Parameters in Men With Erectile Dysfunction erectile dysfunction metabolic syndrome biomarkers vascular health
- Why Some Sperm Can't Swim: A Molecular Tag2026-02-09
Kmal levels were significantly elevated in asthenozoospermic men and inversely correlated with progressive motility across 94 participants
Lysine Malonylation Regulates Human Sperm Motility male infertility semen quality spermatogenesis biomarkers
- Single-Cell Map Reveals Penile Cancer's Immune Blind Spots2026-02-04
A 66,421-cell atlas of penile squamous cell carcinoma identifies SEMA3C-high tumor cells and exhausted T cells as key drivers of metastasis
Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single-Cell RNA Sequencing penile cancer biomarkers immunology genetics
- Rare Testicular Tumors Get Diagnostic Clarity2026-01-26
Review maps how BAP1 and MTAP immunostaining now separate benign from malignant mesothelial lesions of the tunica vaginalis
Mesothelial Lesions of the Testis: A Review pathology testicular disease testicular cancer biomarkers
- A Stain That Spots Penile Precancer2026-01-20
New IHC marker GATA3 lost in 87–100% of HPV-independent penile intraepithelial neoplasia, potentially resolving a longstanding diagnostic ambiguity
GATA3 Is Underexpressed in Penile Neoplasia: Potential Implications in Diagnosis and Pathogenesis penile cancer pathology biomarkers HPV
- 55 Men, OR of 21 — Color Me Skeptical2026-01-07
An enzyme involved in oxidative stress showed lower activity in infertile men — in a study of 55 total subjects
Enzymatic and Genetic Evaluation of Butyrylcholinesterase in Male Infertility male infertility genetics oxidative stress biomarkers case-control study
- New Blood Marker Flags ED — At 71% Accuracy2026-01-05
sTWEAK, an inflammatory cytokine, rose with ED severity in 90 patients vs. 90 controls — AUC 0.776, 71% sensitivity and specificity
New biomarker for erectile dysfunction: Soluble tumor necrosis factor-like weak inducer of apoptosis erectile dysfunction biomarkers vascular health cardiovascular disease
- Semen Vesicles May Diagnose Infertility2025-12-31
Seminal exosomes carry RNA that may help diagnose male infertility — but this review is thin on specifics
Exosomal ncRNAs in Seminal Fluid: Unraveling Their Regulatory Roles in Male Infertility male infertility biomarkers
- PET Scans Outperform CT for Penile Cancer Staging2025-11-29
Review finds FDG PET/CT beats conventional imaging for lymph node staging in penile cancer, though evidence base remains limited.
The Value of FDG PET/CT in Penile Cancer: An Update penile cancer biomarkers surgical outcomes evidence quality
- Penile Cancer Staging Overtreats 80% of Patients2025-11-20
Review argues current DSNB guidelines trigger full lymph node dissection in over 80% of men who wouldn't benefit from it
Sentinel Node Mapping in Penile Cancer: An Update on Methods and Pitfalls penile cancer surgical outcomes evidence quality biomarkers
- Ureaplasma Hits Sperm DNA Without Tanking the Count2025-11-11
UU infection correlated with higher DNA fragmentation index and more abnormal morphology, but most routine semen parameters were unchanged
Effects of Ureaplasma urealyticum Infection on Sperm DNA and Semen Quality male infertility semen quality infertility biomarkers
- A Blood Test May Soon Detect Testicular Cancer2025-10-22
miR-371a-3p is approaching clinical use as a noninvasive diagnostic marker for testicular germ cell tumors
Testicular Germ Cell Tumors and Molecular Biomarkers testicular cancer biomarkers
- Genetics Flags Two New ED Drug Targets2025-06-15
Mendelian randomization across ~325K individuals flagged two candidate drug targets for ED, both expressed in penile endothelial and smooth muscle cells
Identification of potential drug targets for erectile dysfunction with single-cell RNA sequencing: A Mendelian randomization study erectile dysfunction genetics vascular health biomarkers
- Stone Formers' Own Urine Grows More Stones2025-05-23
Urine proteins from calcium oxalate stone patients actively promote crystal formation in vitro, while healthy urine proteins inhibit it — with ~2.5x more oxidized proteins driving the difference.
Urinary Proteins from Stone Formers Promote Calcium Oxalate Crystallization, Growth and Aggregation via Oxidative Modifications kidney stones biomarkers oxidative stress
- One Hormone Test to Find Where Hypogonadism Starts2025-01-20
A narrative review proposes kisspeptin stimulation as the first viable way to tell whether low testosterone originates in the hypothalamus or pituitary.
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders. hypogonadism narrative review biomarkers infertility testosterone