← all papers · systematic review (38) Science journalism, not medical advice.
- Female Testosterone Therapy: Only 2 Trials Back Premenopausal Use2026-07-03
Postmenopausal testosterone therapy has 7 RCTs behind it, premenopausal use has just 2
Testosterone therapy for female sexual dysfunction: a systematic review of the literature demonstrating outcomes in premenopausal and postmenopausal women testosterone therapy women's health sexual dysfunction systematic review menopause
- The Fertility Add-On That Doesn't Add Up2026-07-01
ICSI showed no live birth edge over standard IVF in 1,438 couples without severe male infertility
Does Intracytoplasmic Sperm Injection Outperform Conventional In Vitro Fertilization in Couples Without Severe Male Factor Infertility? A Systematic Review and Meta-Analysis of Randomized Controlled Trials infertility male infertility evidence quality systematic review
- OCD Linked to Female Arousal Problems, Not Male2026-06-30
A 13-study review finds OCD symptoms track with female desire and arousal problems, but the male sexual function data is a wash
The interplay between the obsessive-compulsive disorder and sexual function: a systematic review sexual dysfunction mental health systematic review women's health evidence quality
- Routine Kidney Stone Stents: More Pain, No Benefit2026-06-13
32 RCTs and 3,572 patients find routine double-J stenting after ureteroscopy increases morbidity without improving stone clearance
Does Omitting a Ureteral Stent Affect the Outcomes of Uncomplicated Ureteroscopy for Ureteral and Kidney Stones in Adults? Results from a Systematic Review and Meta-Analysis of Comparative Randomized Trials by the EAU Endourology Section kidney stones surgical outcomes systematic review meta-analysis quality of life
- Sildenafil Wins — But Viatris Paid For It2026-06-05
Network meta-analysis of 83 RCTs finds sildenafil 100mg has the highest odds ratio (9.06) vs placebo — funded by sildenafil's manufacturer
A Comparative Evaluation of On-Demand Phosphodiesterase-5 Inhibitor Efficacy in Erectile Dysfunction Treatment: A Systematic Review and Network Meta-Analysis of Double-Blind, Placebo-Controlled, Randomized Trials erectile dysfunction systematic review meta-analysis pharmacovigilance
- Shockwave, PRP, Stem Cells: Still Not Proven2026-06-05
ISSM-commissioned review of 36 studies finds mixed, inconsistent evidence for all restorative ED therapies, with 78% of trials failing to report clinically meaningful outcomes
Systematic Review on the Safety and Effectiveness of Restorative Therapies for Erectile Dysfunction erectile dysfunction systematic review evidence quality stem cells
- Insulin Pumps May Protect Female Sexual Function2026-05-28
About 1 in 3 women with T1DM has sexual dysfunction — twice the rate of healthy controls, and higher than T2DM
Female Sexual Dysfunction in Type 1 Diabetes: A Systematic Review and Meta-Analysis diabetes sexual dysfunction women's health meta-analysis systematic review
- Online Sex Therapy: 8 Studies, Mostly Cancer Patients2026-05-11
A meta-analysis of 8 studies and 961 participants — mostly cancer patients — found online CBT and psychoeducation measurably improved sexual function
Online Interventions for the Treatment of Sexual Dysfunctions: Systematic Review and Meta-Analysis sexual dysfunction systematic review meta-analysis mental health quality of life
- Exercise Moves the Needle on Prostate Cancer Sex Life2026-05-11
Exercise improved sexual activity (SMD 0.38) and sexual function (SMD 0.32) in prostate cancer patients across 10 RCTs of 558 men
Effects of Exercise on Sexual Activity and Sexual Dysfunction in Patients with Prostate Cancer: A Systematic Review and Meta-Analysis exercise prostate cancer sexual dysfunction systematic review meta-analysis quality of life
- Yes, Exercise Helps ED. The Effect Is Modest.2026-05-11
16 RCTs, 1,477 men: lifestyle interventions improved IIEF scores by 2.35 points — statistically significant, clinically borderline.
Efficacy of Lifestyle Interventions in Treating Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials erectile dysfunction systematic review meta-analysis vascular health exercise
- Exercise Boosts Female Sexual Function—Evidence Weak2026-05-09
Exercise interventions produced a mean 5.31-point FSFI improvement vs. controls (15 studies), but evidence certainty is rated low.
Systematic Review and Meta-Analysis on the Beneficial Effect of Exercise on Sexual Dysfunction in Women sexual dysfunction systematic review meta-analysis women's health pelvic floor evidence quality
- Half of Cancer Survivors Can't Sleep. Nobody's Asking.2026-05-05
Commentary argues sleep disorders go unscreened in testicular cancer follow-up, citing a meta-analysis finding 60.7% prevalence of sleep disturbance across cancer survivors
Integrating the Relevance of Sleep into Testicular-Cancer Survivorship Care testicular cancer survivorship systematic review meta-analysis
- Breast Cancer Therapy's Unspoken Sexual Toll2026-05-04
An integrative review of 43 studies found sexual dysfunction in 51–93% of breast cancer patients on endocrine therapy, yet providers routinely stay silent about it.
Sexual Health Among Patients With Breast Cancer Undergoing Endocrine Therapy: An Integrative Review sexual dysfunction women's health survivorship systematic review
- Lupus Roughly Doubles the Odds of Female Sexual Dysfunction2026-05-04
58.8% of lupus patients screen positive for FSD — 2.6x healthy controls, though extreme heterogeneity muddies the estimate
Prevalence of Female Sexual Dysfunction Among Women with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis sexual dysfunction women's health immunology systematic review meta-analysis epidemiology
- The Psych Treatment That Works Isn't CBT2026-05-01
Overall effect looks strong (SMD=1.37), but CBT and mindfulness had near-zero effect — counseling and education drove the headline.
Psychological Treatments for Sexual Concerns in Perimenopausal and Postmenopausal Women: A Systematic Review and Meta-Analysis menopause women's health sexual dysfunction meta-analysis systematic review mental health
- Silent TB Hides Behind Infertility in 1 in 4 Women2026-04-27
Genital TB found in ~26% of infertile women, with most showing no respiratory symptoms — only infertility
TB Manifests as Infertility: A Systematic Review and Meta-Analysis infertility systematic review meta-analysis women's health tuberculosis
- Treating Rare Tumors Quietly Wrecks Fertility2026-04-15
Review finds chemotherapy has proven fertility harm in NET patients, while somatostatin analogues appear relatively safe — but data on sexual function is nearly absent
Reproductive and Sexual Sequelae of Neuroendocrine Tumour Therapies sexual dysfunction infertility survivorship systematic review
- AI Stone Predictions Work—Until You Pool Them2026-04-15
Only 5 retrospective cohorts met inclusion criteria; heterogeneity was so extreme the authors declared their own pooled estimates "clinically uninterpretable"
Can AI and Predictive Models Accurately Predict Stone-Free Status? A Systematic Review and Meta-Analysis artificial intelligence kidney stones systematic review meta-analysis
- Vitamin D Improves Sperm, Not Pregnancies2026-04-13
Vitamin D boosted sperm motility by 6.96% and testosterone slightly, but had no measurable effect on pregnancy or live birth rates (n=1,168)
Vitamin D supplementation in infertile men: a systematic review and meta-analysis of effects on semen quality and endocrine function male infertility semen quality testosterone meta-analysis systematic review
- The 100-Year-Old Prolapse Surgery That Still Wins2026-04-13
Old uterus-sparing prolapse surgery beat newer techniques on recurrence and cost, but pregnancy data is thin
The Manchester procedure: A systematic review of recurrence, perioperative measures, and financial cost, and a scoping review of sexual dysfunction, gynecologic cancer, and obstetric outcomes surgical outcomes systematic review scoping review women's health
- Pelvic Muscle Tears After Birth: Sex Impact Unclear2026-04-11
9 studies, 1,623 women: only 2 of 9 found a link between levator ani avulsion and postpartum sexual dysfunction
The Relationship Between Levator Ani Integrity and Postpartum Sexual Dysfunction: A Systematic Review systematic review pelvic floor sexual dysfunction women's health pregnancy
- Sling Surgery Lifts Sexual Function at 6 Months, Then Fades2026-04-09
MUS surgery improved PISQ-12 scores by 4.49 points at 6 months, but the gains largely reversed by 12 months and didn't recover
Impact of Mid-Urethral Sling Surgery on Sexual Function in Women with Stress Urinary Incontinence: A Meta-Analysis of Randomized Controlled Trials meta-analysis systematic review sexual dysfunction pelvic floor surgical outcomes women's health urinary incontinence
- After Anal Cancer Radiation, Sexual Damage Persists for Years2026-04-09
32 studies found vaginal dryness in up to 98% of women after anal cancer radiotherapy — and it often doesn't resolve
Prevalence, Risk Factors, and Interventions for Female Sexual Dysfunction After Radiotherapy for Anal Cancer: A Systematic Review systematic review sexual dysfunction survivorship women's health pelvic floor
- Could Infertility Predict Brain Disease? Too Soon to Tell2026-04-02
13-study systematic review finds preliminary mechanistic overlap between male infertility and neurodegeneration — no prospective evidence yet
Male Infertility and Neurodegenerative Diseases: A Systematic Review of Associations and Molecular Mechanisms systematic review male infertility neurodegenerative diseases oxidative stress biomarkers
- Shockwave Therapy for ED: Short-Term Gains Fall Below the Meaningful Threshold2026-03-30
Cochrane review of 21 RCTs finds LiSWT may improve erectile function, but the short-term effect (MD 3.89 points) falls below the 4-point minimal clinically important difference — and all evidence is low certainty.
Low-intensity shockwave therapy for erectile dysfunction: An abridged Cochrane review erectile dysfunction systematic review meta-analysis evidence quality
- Weight Loss Surgery Raises Testosterone — But Not the Free Kind2026-03-25
21 studies, 695 men: bariatric surgery improved IIEF-5 scores by 6.45 points and raised total testosterone, but free testosterone didn't move
The impact of bariatric surgery on male sexual function: a systematic review and meta-analysis obesity erectile dysfunction testosterone meta-analysis systematic review surgical outcomes
- Every Common Kidney Stone Fix Has Weak Evidence2026-03-24
31-study review finds "low" strength-of-evidence for nearly every kidney stone prevention strategy, and zero data on surveillance imaging
Prevention of Recurrent Nephrolithiasis in Adults and Children: A Systematic Review kidney stones systematic review evidence quality pediatric urology
- Vaginal Surgical Access Rarely Damages Sex Life2026-03-18
Across 30 studies and 2,488 women, transvaginal specimen extraction showed low rates of postoperative dyspareunia and no clinically meaningful decline in sexual function scores.
Dyspareunia and Sexual Dysfunction After Transvaginal Specimen Extraction — A Systematic Review surgical outcomes sexual dysfunction women's health systematic review
- When Your Body Attacks Your Own Sperm2026-03-12
Editorial overview of a themed issue: blood-testis barrier, antisperm antibodies, seminal cytokines, and genital pathogens as fertility disruptors
Male Infertility and Immune Function immunology male infertility semen quality systematic review narrative review inflammation antisperm antibodies
- HPV Raises Antisperm Antibodies Tenfold2026-03-11
GU infections were linked to measurable sperm parameter declines, but pregnancy outcomes mostly held — HPV was the outlier, with a tenfold antisperm antibody spike
Impact of Male Genital Tract Infections on Semen Quality: A Systematic Review and Meta-Analysis male infertility semen quality systematic review meta-analysis HPV antisperm antibodies inflammation
- Half of Asthma Patients Report Sexual Dysfunction2026-03-08
Meta-analysis found sexual dysfunction in 54% of asthma patients and 19% with atopic dermatitis
Global Prevalence of Sexual Dysfunction in Individuals With Atopic Dermatitis and Asthma: A Systematic Review and Meta-Analysis sexual dysfunction meta-analysis systematic review epidemiology
- Can AI Read Sperm Better Than Humans?2026-03-03
Systematic review maps AI applications in male fertility — sperm analysis, treatment prediction — but reports no pooled numbers
Artificial Intelligence and Infertility: A Systematic Review male infertility systematic review semen quality artificial intelligence
- After Pelvic Radiation, Sexual Recovery Is Partial2026-02-18
26 studies, 5,646 patients: pelvic radiation reliably causes vaginal dryness, dyspareunia, and lasting sexual dysfunction — dilation helps some, not all
A Systematic Review of Patient-Reported Outcomes on the Impact of Radiation Therapy on Sexual Health in Patients With Gynecologic Cancer systematic review sexual dysfunction cancer survivors women's health survivorship quality of life
- AAS and ED: Most Reviews Nearly Worthless2026-02-12
Six systematic reviews on AAS-induced ED: four rated critically low confidence, one low, one medium
Erectile Dysfunction and Related Variables Due to Anabolic Steroid Use: A Review of Reviews erectile dysfunction hypogonadism systematic review evidence quality anabolic steroids
- 67 Sperm Risk Factors, Almost All Weak Evidence2026-01-13
67 risk factors linked to male infertility catalogued — but 78% of the underlying evidence rated low or very low quality
Current Risk Factors for Male Infertility and Semen Parameters: An Umbrella Review of Systematic Reviews and Meta-Analyses male infertility semen quality evidence quality environmental exposure systematic review meta-analysis
- Obesity and ED: 23 Studies, Still No Clear Answer2025-12-03
23 studies, 52,981 men — and researchers still can't agree on how common ED is in obese men
Prevalence and Incidence of Erectile Dysfunction in Men With Overweight and Obesity: A Systematic Literature Review erectile dysfunction obesity systematic review metabolic syndrome
- A $165 to $101,510 Gap for the Same Surgery2025-09-15
The same kidney stone operation (PCNL) costs anywhere from $165 to $101,510 depending on where it's done — a 615-fold gap that makes cost comparisons nearly meaningless
Costs of Resolving a Ureteral or Kidney Stone Episode Worldwide: A Systematic Review kidney stones health services systematic review surgical outcomes
- A Rare Penile Condition With Almost No Research2025-07-07
Only 8 studies exist on hard-flaccid syndrome — most are case reports, leaving diagnosis and treatment without any established guidelines.
Hard-Flaccid Syndrome: A Systematic Review of Aetiopathophysiology, Clinical Presentation and Management erectile dysfunction sexual dysfunction systematic review pelvic floor case report