← all papers · narrative review (35) Science journalism, not medical advice.
- The Testicular Tumors That Fool Even Pathologists2026-05-17
10% of testicular sex cord stromal tumors follow an aggressive, therapy-resistant course that can rapidly become fatal
Testicular Sex Cord Stromal Tumors testicular cancer testicular disease pathology narrative review
- Gut Bacteria May Hurt Sperm. The Evidence Is Thin.2026-05-16
A plausible gut-testis axis linking dysbiosis to poor sperm quality — authors themselves admit few human studies back it up
Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions gut microbiome male infertility spermatogenesis narrative review testosterone inflammation
- Curable Cancer That Still Kills Young Men2026-05-14
Testicular cancer is among the most curable metastatic solid tumors — but the poor-risk subset still carries significant mortality in young men
How to Optimize Treatment for Patients With Poor-Risk Testicular Cancer testicular cancer narrative review surgical outcomes survivorship
- Immune War in the Testis — Mostly Mouse Data2026-05-12
A review proposes that a shared immune-inflammatory cascade disrupts sperm production — then admits most evidence comes from animals, not men.
Immunological Mechanisms and Precision Stratification in Male Infertility immunology male infertility inflammation oxidative stress narrative review biomarkers spermatogenesis
- Plastic Chemicals May Rewrite Fertility Across Generations2026-05-08
A narrative review argues BPA harms male fertility via gut dysbiosis and epigenetic marks — but admits the transgenerational evidence is provisional at best
Transgenerational Exposure to Plastics-Derived Endocrine-Disrupting Bisphenol A and Its Analogs on Male Infertility: Impact of Gut Dysbiosis and Epigenetic Regulation environmental exposure epigenetics male infertility narrative review spermatogenesis gut microbiome
- Diabetes Breaks Both Sperm and Memory — Here's How2026-05-08
A narrative review proposes shared neuroendocrine-immune pathways linking diabetic infertility and cognitive decline — no new data, theory only
The relationships between diabetic male infertility, diabetic cognitive impairment, and the neuroendocrine-immune network: A review diabetes male infertility narrative review spermatogenesis neurodegenerative diseases
- Female Sexual Dysfunction: Still Playing Catch-Up2026-05-07
Narrative review from Duke maps all 4 DSM-5 subtypes of female sexual dysfunction and finds evidence for multiple treatments—but measurement tools remain unstandardized
Female Sexual Dysfunction: Current Models and Treatment Options sexual dysfunction women's health narrative review pelvic floor
- Testicular Cancer Gets Its First Moderate-Risk Gene2026-05-06
CHEK2 becomes the first moderate-penetrance predisposition gene identified for testicular germ cell tumors, alongside growing ties to inherited cancer syndromes
Recent Advances in Genetic Predisposition to Primary Testicular Tumors testicular cancer genetics genomics narrative review
- Lab-Grown Mini-Testes Make Hormones — Sperm Still Elusive2026-05-06
Testicular organoids sustain testosterone and inhibin B production for up to 12 weeks in culture, but complete spermatogenesis remains out of reach
Generation and Utility of Endocrine Functional Testicular Organoids stem cells spermatogenesis male infertility narrative review testicular disease
- A Third Way Sperm Cells Die: Ferroptosis2026-05
Review maps three oxidative stress-driven cell death pathways in testicular tissue, spotlighting ferroptosis as an understudied mechanism
Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis male infertility oxidative stress spermatogenesis narrative review iron metabolism autophagy
- Melatonin for Low Testosterone: Interesting Theory, No Trials2026-05
Chinese TCM researchers propose melatonin could restore endogenous testosterone by repairing aging Leydig cells — supported by animal data and zero LOH clinical trials
From "Passive Supplementation" to "Active Repair": Melatonin Reshapes the Treatment Paradigm for Late-Onset Hypogonadism by Targeting Leydig Cell Senescence hypogonadism testosterone oxidative stress narrative review traditional chinese medicine
- Shockwave and PRP for ED? Still Experimental, Review Concludes2026-04-30
Narrative review synthesizes the full ED treatment ladder — prosthetics top 95% satisfaction; shockwave and PRP remain experimental.
Erectile Dysfunction: A Comprehensive Review of Pathophysiology, Diagnosis and Contemporary Management erectile dysfunction narrative review penile prosthesis sexual dysfunction evidence quality
- Your Genes, Not Your Diet, May Drive Low Phosphate2026-04-30
Narrative review argues that low phosphate in stone formers is driven by genetic defects in kidney transporters, not diet—and that supplementation may cut recurrence.
Hypophosphatemia in Kidney Stone Formers kidney stones genetics narrative review biomarkers
- Can Metformin Treat Male Infertility?2026-04-29
Review argues AMPK—an energy-sensing enzyme disrupted by obesity and diabetes—could be a druggable target for male infertility
Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies male infertility metabolic syndrome spermatogenesis narrative review oxidative stress testosterone
- Sperm Create the Toxins That Destroy Them2026-04-25
Oxidative stress causes at least one-third of male infertility, and sperm generate the damaging reactive oxygen species themselves
Molecular Advances in Male Infertility and Fertility: Importance of Redox Regulation and Oxidative Stress male infertility oxidative stress sperm capacitation narrative review
- Dyslipidemia and ED: Plausible but Not Proven2026-04-22
A review maps five pathways linking dyslipidemia to ED, then concedes direct evidence for all five is limited
Mechanisms of Dyslipidemia-Induced Erectile Dysfunction: A Narrative Review erectile dysfunction narrative review cardiovascular disease vascular health metabolic syndrome oxidative stress
- Beyond Overheating: Varicocele's Multi-Front War on Sperm2026-04-15
Narrative review maps varicocele's damage chain: dilated veins trigger heat, oxidative damage, inflammation, and immune attacks that collectively wreck sperm
Testicular Microenvironment Disruption in Varicocele: Mechanisms and Implications for Spermatogenesis varicocele male infertility oxidative stress spermatogenesis narrative review
- Cancer Clinics Are Dropping the Ball on Sexual Health2026-04
Sexual dysfunction is common across cancer types but rarely addressed in oncology care, per this narrative review — no numbers provided
Oncosexology: A Narrative Review on Sexual Health and Quality of Life in Cancer Patients sexual dysfunction survivorship narrative review women's health
- Plant Compounds in Nanopackages Won't Fix ED Yet2026-03-24
Chemical engineering duo reviews plant-derived compounds delivered via nanoparticles for ED — heavy on preclinical data, light on clinical evidence
Phytochemical-Based Nanomedicine as a Promising Therapeutic Strategy for Erectile Dysfunction erectile dysfunction narrative review oxidative stress nanomedicine
- When the Testes Lose Their Immune Shield2026-03-17
A narrative review estimates up to 15% of male infertility stems from immune dysregulation at the blood-testis barrier
Testicular Immune Privilege Revisited: When Protection Fails male infertility immunology narrative review antisperm antibodies spermatogenesis infertility
- Sperm's Chemical Entourage Signals the Uterus2026-03-16
Review argues seminal cytokines don't just carry sperm — they actively shape uterine receptivity and embryo implantation
Seminal Fluid Cytokines in Reproductive Health and Fertility of Men male infertility immunology semen quality inflammation narrative review
- Sperm-Only Ion Channels Could Enable Male Contraception2026-03-12
A review of the ion transport machinery in sperm membranes — some of it unique to sperm — and why mutations in these systems cause infertility
The systems that transport ions and their impact on sperm function and male fertility. male infertility sperm capacitation genetics contraception narrative review
- When Your Body Attacks Your Own Sperm2026-03-12
Editorial overview of a themed issue: blood-testis barrier, antisperm antibodies, seminal cytokines, and genital pathogens as fertility disruptors
Male Infertility and Immune Function immunology male infertility semen quality systematic review narrative review inflammation antisperm antibodies
- Does Your Doctor Ask About Your Sex Life?2026-03-11
A 2026 review maps primary care's role in four sexual health conditions: ED, premature ejaculation, sexual pain, and low desire.
Addressing Sexual Health in Primary Care erectile dysfunction premature ejaculation sexual dysfunction health services narrative review
- When Your Immune System Attacks Your Sperm2026-03-09
Antisperm antibodies affect 5–12% of infertile men; immunosuppression was abandoned as ineffective — ICSI now mechanically bypasses the immune barrier at >80% antibody binding
Antisperm Antibodies and Autoimmunity in the Era of Assisted Reproduction male infertility immunology antisperm antibodies narrative review
- Breaking Kidney Stones While You're Wide Awake2026-03-05
Early clinical data suggests BWL fragments kidney and ureteral stones in awake patients with mostly minor side effects — but the evidence base is still thin.
Burst Wave Lithotripsy: Insights on Effectiveness and Safety kidney stones narrative review surgical outcomes
- It's Not Age That Tanks Testosterone2026-02-06
Review of current evidence finds aging alone doesn't cause low T — obesity and diabetes do, and recent RCTs report no added cardiovascular risk from treatment
Functional Testosterone Deficiency in Aging Men: Clinical Impact, Diagnostic Pathways, and Treatment Strategies hypogonadism testosterone therapy metabolic syndrome narrative review
- Men Think Average Is Small. Research Agrees They're Wrong.2026-01-20
Only 7 studies exist on this topic — all found men overestimate what's "normal" in size and sexual performance while underestimating their own normalcy
Are Men Aware of Normal Penile Length and Sexual Function? A Narrative Review narrative review sexual dysfunction erectile dysfunction evidence quality
- EAU Panel: Varicocele Surgery for Azoospermia? Evidence Too Weak2025-12-23
EAU guidelines panel finds the evidence for varicocele surgery in nonobstructive azoospermia too weak to support a strong recommendation
Varicocele Treatment in Azoospermia Before Artificial Reproductive Techniques: Critical Considerations by the EAU Guidelines Panel on Sexual and Reproductive Health varicocele male infertility evidence quality narrative review
- When Pelvic Floor Therapy Conflicts With Trauma2025-12-17
~15% of French women report lifetime sexual violence; this review flags intravaginal PT as a trauma conflict for pelvic pain patients
Pelvic Floor Physical Therapy for Sexual Abuse Survivors With Pelvic Pain pelvic floor women's health sexual dysfunction narrative review vaginismus
- Three Guidelines on Penile Cancer Can't Agree2025-11-19
Three major oncology guideline bodies disagree on lymph node staging and treatment in penile cancer, leaving surgeons without consensus at every decision point.
Penile Cancer and Lymph Node Management: A Call for Standardization penile cancer surgical outcomes narrative review evidence quality
- Sperm's "Power Plant" Role Has Been Overstated2025-11-11
The textbook model of sperm energy production — mitochondria fuel the tail — is more complicated than it looked
Sperm mitochondrial sheath formation - how and why? male infertility spermatogenesis narrative review infertility
- FSH Pharmacogenetics: Interesting Science, Unusable Data2025-04-30
Genetic variants in FSH and its receptor affect sperm production, but current evidence is too small and contradictory for clinical use
Pharmacogenetics of Follicle-Stimulating Hormone Action in the Male male infertility genetics infertility narrative review spermatogenesis
- hCG for Azoospermia: Settled Science for One Type, Guesswork for the Rest2025-02-04
A narrative review argues hCG may treat more azoospermia subtypes than currently accepted, introducing the unvalidated "APHRODITE criteria" to guide patient selection.
Human Chorionic Gonadotropin-Based Clinical Treatments for Infertile Men with Non-Obstructive Azoospermia male infertility spermatogenesis hypogonadism narrative review
- One Hormone Test to Find Where Hypogonadism Starts2025-01-20
A narrative review proposes kisspeptin stimulation as the first viable way to tell whether low testosterone originates in the hypothalamus or pituitary.
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders. hypogonadism narrative review biomarkers infertility testosterone