← all papers · infertility (33) Science journalism, not medical advice.
- The Fertility Add-On That Doesn't Add Up2026-07-01
ICSI showed no live birth edge over standard IVF in 1,438 couples without severe male infertility
Does Intracytoplasmic Sperm Injection Outperform Conventional In Vitro Fertilization in Couples Without Severe Male Factor Infertility? A Systematic Review and Meta-Analysis of Randomized Controlled Trials infertility male infertility evidence quality systematic review
- Vitamins Topped Every Other Lifestyle Factor in IVF2026-06-10
Of 501 couples undergoing IVF, the only factor linked to pregnancy when both partners were assessed together was taking vitamins, minerals, and trace elements
Occupational and Lifestyle Factors of Male and Female Infertility Patients: Do They Impact ART Success? infertility male infertility occupational exposure pregnancy cohort study
- Your Father's Chemical Exposure May Shape Your Health2026-06-03
Review links six ubiquitous EDC classes to sperm damage and transgenerational harm — paternal occupational exposure tied to low birth weight and congenital heart disease in offspring
Endocrine Disruption and Male Fertility environmental exposure epigenetics male infertility semen quality oxidative stress infertility
- Oxidative Lipid Damage Markers: A New IVF Yardstick?2026-05-23
A narrative review argues F2-isoprostanes and isofurans could be stable, reliable markers of reproductive oxidative damage — but admits the evidence base is thin
Isoprostanes and Isofurans in Infertility and Assisted Reproduction: What Do We Know So Far? oxidative stress infertility male infertility biomarkers narrative review semen quality
- Brain Immune Cells Gatekeep Fertility Hormones2026-05-21
Brain immune cells (microglia) use RANK signaling to control GnRH neurons — and rare RANK variants show up in 564 hypogonadism patients
Microglia Rank Signaling Regulates GnRH Neuronal Function and the Hypothalamic-Pituitary-Gonadal Axis hypogonadism infertility genetics animal study
- Silent TB Hides Behind Infertility in 1 in 4 Women2026-04-27
Genital TB found in ~26% of infertile women, with most showing no respiratory symptoms — only infertility
TB Manifests as Infertility: A Systematic Review and Meta-Analysis infertility systematic review meta-analysis women's health tuberculosis
- Whose Infertility Hurts Whom More?2026-04-21
Female-factor infertility lowered male partners' wellbeing scores; male-factor infertility had no detectable effect on female partners
Male- and Female-Factor Infertility and Partners' Quality of Life During ART infertility male infertility cross-sectional quality of life
- Genetic Cause Found in Only 1 in 4 Female IHH Cases2026-04-18
Only 4 of 17 sequenced female IHH patients (23.5%) had an identifiable pathogenic variant; the majority remain genetically undiagnosed
Genetic variants analysis of 17 female patients with idiopathic hypogonadotropic hypogonadism genetics genomics hypogonadism women's health infertility
- Treating Rare Tumors Quietly Wrecks Fertility2026-04-15
Review finds chemotherapy has proven fertility harm in NET patients, while somatostatin analogues appear relatively safe — but data on sexual function is nearly absent
Reproductive and Sexual Sequelae of Neuroendocrine Tumour Therapies sexual dysfunction infertility survivorship systematic review
- Adding Testosterone Cuts Drug Dose, Not Sperm Rates2026-04-01
Triple therapy (hCG + FSH + testosterone) cut the median hCG dose needed by 17% but didn't significantly improve spermatogenesis rates in 45 CHH men
Comparing the response of triple therapy and conventional treatment in male congenital hypogonadotropic hypogonadism: a randomized controlled trial hypogonadism spermatogenesis testosterone infertility
- Infant Hormone Window Predicts Adult Fertility2026-03-26
Hormone levels at 1–3 months of life predict adult reproductive capacity and can flag hypogonadism before symptoms appear
Clinical Implications of Minipuberty pediatric urology hypogonadism biomarkers infertility
- Male Fertility Prevention: Everything but the Numbers2026-03-18
Narrative review maps primary-to-tertiary prevention in male reproductive health — broad scope, no original data, no quantified effect sizes
Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review male infertility biomarkers infertility screening evidence quality
- When the Testes Lose Their Immune Shield2026-03-17
A narrative review estimates up to 15% of male infertility stems from immune dysregulation at the blood-testis barrier
Testicular Immune Privilege Revisited: When Protection Fails male infertility immunology narrative review antisperm antibodies spermatogenesis infertility
- AI Will Fix Male Infertility (Trust Us)2026-03-16
A solo computer scientist argues LLMs could transform male infertility research — with zero data to show for it
Future directions in infertility research: the role of generative AI and large language models. male infertility infertility genetics epigenetics
- Gum Disease and Infertility: Mostly Speculation So Far2026-03-08
A narrative review argues gum disease may worsen fertility via inflammation, but admits the human data barely supports it
Infertility and Periodontitis: Are We Connecting the Right Dots? infertility male infertility inflammation oxidative stress narrative review
- 1 in 4 Infertile Women at Risk for Sexual Dysfunction2026-03-01
25% of women and 7% of men newly diagnosed with unexplained infertility screen positive for sexual dysfunction
Sexual Functioning and Its Determinants in Couples with Unexplained Infertility infertility sexual dysfunction
- Lab-Grown Sperm: Closer, But Not There2026-03-01
Narrative review maps iPSC-to-sperm progress — validated precursor cells exist, but maturation to functional sperm remains unsolved
The road to restore male fertility using in vitro-derived germ cells male infertility infertility genetics stem cells
- AMH Flags Azoospermia But Can't Predict Sperm Count2026-02-20
AMH is lower in men with non-obstructive azoospermia, but doesn't independently predict sperm concentration once FSH and testicular volume are accounted for
Serum Antimüllerian Hormone as a Biomarker of Functional Testicular Reserve: A Comparative Analysis male infertility biomarkers semen quality infertility
- Osteoporosis Drug Fails Oligospermia Trial2026-02-20
Denosumab 60 mg produced no improvement in sperm concentration over placebo in 39 men with severe oligospermia
Effect of Denosumab on Sperm Concentration in Men With Severe Oligospermia: A Randomized Controlled Trial male infertility semen quality infertility
- The Infertility Fallback Guide Ferring Helped Write2026-02-19
Industry-sponsored "expert opinion" recommends gonadotropins + hCG luteal support when pulsatile GnRH therapy is unavailable — no original data included
Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion. infertility women's health evidence quality hypogonadism
- Scrotal Calcifications Don't Trigger Immune Attack2026-02-06
In 1,755 infertile men, testicular microlithiasis was not associated with higher antisperm antibody rates (1.2% vs 3.5%, p=0.17)
Testicular Immune Privilege Maintained in Incidental Testicular Microlithiasis: Evidence from 1755 Infertile Men testicular disease infertility immunology semen quality
- Same DNA Repair Flaw, Infertile Men and Women2026-02-05
Exome sequencing of three consanguineous families found homozygous loss-of-function variants in SPIDR, TOP6BL, or RAD51AP2 — all meiotic DNA repair genes — causing infertility in both sexes.
Disruption of Meiotic Double-Strand Break Dynamics Provokes Germline Human Infertility in Both Sexes genetics male infertility infertility spermatogenesis
- When Infertility Care Forgets the Man2026-01-13
Male factor causes about half of infertility cases yet men are often left out of their own care
Procreation, Potency, and the Price of Paternity: The Social and Psychological Impact of a Diagnosis of Male Factor Infertility male infertility mental health infertility relationship health
- Genetic Testing Solves Only 1 in 13 Infertility Cases2026-01-03
India's largest male infertility genomics cohort found a genetic cause in just 7.7% of 247 men with severe sperm defects
Genetic Diversity of Infertile Males in India genetics male infertility spermatogenesis infertility
- Antioxidants Out, Varicocele Repair In: WHO Rules2026
WHO's first unified infertility guideline backs varicocele repair conditionally but won't endorse antioxidants—evidence too heterogeneous
The WHO 2025 Guideline for the Prevention, Diagnosis and Treatment of Infertility: A Comprehensive Review with Focus on Male Reproductive Health male infertility infertility evidence quality semen quality
- Blood Type O and Infertility: Weak Signal, Big Caveats2025-12-19
Blood type O was overrepresented in infertile couples (39.5% vs 34.2%), but effect sizes were weak and key findings didn't survive correction
ABO Blood Group Distribution and Infertility Risk in Southern China: A Retrospective Analysis of the Ganzhou Region male infertility infertility genetics semen quality
- Obesity Wrecks Fertility in Both Sexes2025-11-27
Narrative review of how adiposity impairs reproduction — admits the fix is unclear
Obesity and Infertility: A Double Whammy infertility obesity
- Sperm's "Power Plant" Role Has Been Overstated2025-11-11
The textbook model of sperm energy production — mitochondria fuel the tail — is more complicated than it looked
Sperm mitochondrial sheath formation - how and why? male infertility spermatogenesis narrative review infertility
- Ureaplasma Hits Sperm DNA Without Tanking the Count2025-11-11
UU infection correlated with higher DNA fragmentation index and more abnormal morphology, but most routine semen parameters were unchanged
Effects of Ureaplasma urealyticum Infection on Sperm DNA and Semen Quality male infertility semen quality infertility biomarkers
- Surgically Retrieved Sperm Drags Down IVF Success2025-09-20
Testicular sperm extraction cut live birth rates vs. ejaculated sperm in ICSI — but only cumulative, not first-transfer outcomes
Effect of Abnormal Semen Parameters on ICSI: Morphokinetics and Cumulative Clinical Outcomes of 10,623 Embryos male infertility semen quality infertility surgical outcomes
- A New Heart Helps Your Sex Life. A New Pancreas Doesn't.2025-07-08
Transplantation linked to a 2.11% absolute drop in coded sexual dysfunction in men — statistically real, clinically modest
The Impact of Solid Organ Transplantation on Sexual Dysfunction and Infertility in Older Men and Women: A Claims-Based Study sexual dysfunction erectile dysfunction infertility retrospective cohort health services surgical outcomes
- FSH Pharmacogenetics: Interesting Science, Unusable Data2025-04-30
Genetic variants in FSH and its receptor affect sperm production, but current evidence is too small and contradictory for clinical use
Pharmacogenetics of Follicle-Stimulating Hormone Action in the Male male infertility genetics infertility narrative review spermatogenesis
- One Hormone Test to Find Where Hypogonadism Starts2025-01-20
A narrative review proposes kisspeptin stimulation as the first viable way to tell whether low testosterone originates in the hypothalamus or pituitary.
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders. hypogonadism narrative review biomarkers infertility testosterone