← all papers · pathology (19) Science journalism, not medical advice.
- The Testicular Tumor That Fools Every Blood Test2026-06-19
A 21-year-old's painless testicular mass turned out to be a tumor type so rare it accounts for under 1% of testicular neoplasms — and all standard tumor markers came back normal.
Primary Testicular Neuroendocrine Tumor: Diagnostic Challenges and WHO 2022 Classification Insights case report testicular cancer testicular disease pathology biomarkers
- Bile Pigment Spotted Where Kidney Stones Form2026-06-04
Red-orange crystals in 1.1% of Randall's plaque stones were identified as calcium bilirubinate — a bile pigment — possibly linked to liver disease.
Calcium Bilirubinate at the Randall's Plaque-Kidney Stone Interface: First Description kidney stones pathology retrospective cohort case report
- The Testicular Tumors That Fool Even Pathologists2026-05-17
10% of testicular sex cord stromal tumors follow an aggressive, therapy-resistant course that can rapidly become fatal
Testicular Sex Cord Stromal Tumors testicular cancer testicular disease pathology narrative review
- Burned-Out Testis After Chemo Rarely Hides Viable Tumor2026-04-03
After chemo for metastatic testicular cancer, no viable invasive tumor was found in men whose post-chemo ultrasound showed normal, burned-out, or sub-centimeter residual findings.
Postchemotherapy Orchiectomy in Metastatic Testicular Germ Cell Tumors: Pathologic Findings and Predictors of Residual Viable Disease testicular cancer pathology surgical outcomes retrospective cohort
- Dog Tumor Marker Study Oversells Its Findings2026-03-31
87% of canine testicular seminomas expressed ezrin; higher expression correlated with the more invasive diffuse subtype (n=23)
Histomorphological Features and Ezrin Expression in Testicular Seminomas in Dogs: An Association with Potential Prognostic Value animal study testicular cancer pathology biomarkers
- The Testicular Tumor Hiding Behind Wrong Diagnoses2026-03-19
A review of an ultra-rare testicular malignancy, defined by EWSR1::ATF1 gene fusions, that has been routinely misclassified as other tumor types
Inflammatory and Nested Testicular Sex Cord Tumors: Clinical and Molecular Characterization testicular cancer genetics pathology biomarkers
- Can Protein Tangles Kill Prostate Cancer Cells?2026-02-25
Review surveys disulfidptosis — a newly described cell death mechanism — as a theoretical target in prostate, testicular, and bladder cancer; no original data
Disulfidptosis and Androgenic Cancers: From Molecular Mechanisms to Clinical Applications and Future Translational Research prostate cancer testicular cancer pathology oxidative stress
- Ultrasound Pattern Could Spare Testicles From Surgery2026-02-06
17 men with testicular sarcoidosis had tiny, stable nodules that mimicked cancer on ultrasound
Multiparametric Ultrasound Findings of Testicular Sarcoidosis testicular disease case report pathology testicular cancer
- Sertoli vs. Leydig: New Marker, Tiny Sample2026-02-03
LEF1 stained positive in all 5 Sertoli cell tumors and zero of 12 Leydig cell tumors — promising signal, absurdly small dataset
LEF1 and IL13RA2 in Testicular Sex Cord-Stromal Tumors: LEF1 as a Potential Diagnostic Marker for Sertoli Cell Tumors testicular cancer pathology biomarkers retrospective cohort
- Rare Testicular Tumors Get Diagnostic Clarity2026-01-26
Review maps how BAP1 and MTAP immunostaining now separate benign from malignant mesothelial lesions of the tunica vaginalis
Mesothelial Lesions of the Testis: A Review pathology testicular disease testicular cancer biomarkers
- HPV Splits Penile Cancer Into Two Paths2026-01-22
Moffitt Cancer Center classifies intraepithelial penile lesions by HPV status and cancer risk
Intraepithelial Penile Lesions penile cancer pathology
- A Stain That Spots Penile Precancer2026-01-20
New IHC marker GATA3 lost in 87–100% of HPV-independent penile intraepithelial neoplasia, potentially resolving a longstanding diagnostic ambiguity
GATA3 Is Underexpressed in Penile Neoplasia: Potential Implications in Diagnosis and Pathogenesis penile cancer pathology biomarkers HPV
- Rare Scrotal Cyst Mistaken for Tumor, Costs a Testicle2026-01-19
Meconium periorchitis — a sterile scrotal mass affecting 1 in 30,000 newborns — is routinely misdiagnosed as teratoma, potentially driving unnecessary orchiectomy
Meconium Periorchitis case report pediatric urology testicular disease pathology
- Two Genes Predict Penile Cancer Outcomes2026-01-05
A 2026 pathologist-facing review codifies how HPV status and TP53 mutations should shape penile cancer prognosis
Select Updates in Pathology of Kidney, Testis, and Penile Cancer for 2026 penile cancer testicular cancer kidney cancer pathology
- Rare Ovarian Tumor: DICER1 in Every Case2025-12-15
In 11 cases of this exceptionally rare ovarian tumor type, 100% harbored DICER1 mutations and 86% carried double mutations, pointing to DICER1 as the primary driver.
Ovarian Sertoli-Leydig Cell Tumors with Heterologous Rhabdomyosarcoma: Clinicopathologic Features and Molecular Analysis Highlighting Recurrent Genetic Alterations pathology genetics women's health
- Intraoperative Biopsy Saved 81 Testes From Unnecessary Removal2025-11-20
Frozen section biopsy correctly identified 58% of small testicular masses as benign, sparing those patients radical orchidectomy — with zero false negatives across 135 cases.
Testicular Mass Frozen Section Examination: Pathological Insights and Diagnostic Accuracy testicular cancer testicular disease surgical outcomes pathology
- When the "Tumor" Was Just Misplaced Spleen2025-11-17
A 10-year-old's para-testicular "tumors" turned out to be ectopic splenic tissue — a rare anomaly that can prevent unnecessary surgery if recognized
An Unexpected Bond: Unraveling a Case of Spleno-Gonadal Fusion Anomaly Mistaken for Lymph Node and Testicular Tumor case report cryptorchidism pediatric urology testicular disease pathology
- The Vote That Ended PeIN Grading2025-08-20
112 pathologists surveyed on how to classify penile precancer; 82% ultimately voted to abandon grading after starting nearly split 51/49
International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 Report on Terminology, Grading, and Molecular Testing Practices penile cancer HPV pathology biomarkers
- Massive Genital Swelling: No Protocol Exists2024-12-04
No evidence-based treatment protocol exists for penoscrotal elephantiasis, a rare lymphatic condition causing irreversible penile and scrotal swelling
Operative Management of Penoscrotal Elephantiasis narrative review surgical outcomes inflammation pathology