← all papers · traditional chinese medicine (12) Science journalism, not medical advice.
- Melatonin for Low Testosterone: Interesting Theory, No Trials2026-05
Chinese TCM researchers propose melatonin could restore endogenous testosterone by repairing aging Leydig cells — supported by animal data and zero LOH clinical trials
From "Passive Supplementation" to "Active Repair": Melatonin Reshapes the Treatment Paradigm for Late-Onset Hypogonadism by Targeting Leydig Cell Senescence hypogonadism testosterone oxidative stress narrative review traditional chinese medicine
- TCM Sperm Pill: 56 Animal Studies, 8 Human Trials2026-04-16
A PRISMA-screened evidence map finds mechanistic plausibility but only 8 clinical trials — most evidence is animal data
Multi-component, multi-target actions of Wuzi Yanzong Pill in male infertility: An evidence map linking clinical signals to mechanistic networks. male infertility traditional chinese medicine spermatogenesis oxidative stress evidence quality
- A Chinese Herbal Formula Targets Iron Cell Death — in Rats2026-04
TCM formula SFZYD reduced ferroptosis markers and improved erectile function in diabetic rats via the Nrf2/HO-1/GPX4 pathway — no human data
Mechanism of Shaofu Zhuyu Decoction in Improving Diabetes Mellitus Erectile Dysfunction Inhibition of Ferroptosis Based on Network Pharmacology and Experimental Validation diabetes erectile dysfunction traditional chinese medicine oxidative stress animal study
- PE, Anxiety, and SSRIs: One Broken System2026-03-17
A 2026 narrative review maps how serotonin and BDNF link premature ejaculation to comorbid anxiety and depression — and makes a pitch for TCM adjuncts
Role of 5-HT and BDNF in Premature Ejaculation With Anxiety or Depression sexual dysfunction antidepressants traditional chinese medicine biomarkers
- Horny Goat Weed Gets a Mechanistic Review2026-02-26
A narrative review maps how icariin, horny goat weed's active compound, may improve sperm function — mostly in rodents
Icariin in Male Reproduction: Multi-Target Pharmacological Mechanisms and Therapeutic Potential traditional chinese medicine male infertility oxidative stress animal study spermatogenesis
- TCM for ED: Mostly Animal Data, Few Clinical Trials2026-02-13
A narrative review of TCM mechanisms for ED — heavy on preclinical theory, thin on human evidence
Mechanism of traditional Chinese medicine in treating erectile dysfunction: A review erectile dysfunction traditional chinese medicine animal study
- Plant Compound Cuts Kidney Crystals—In Mice Only2026-02-09
Luteolin reduced calcium oxalate crystal deposition in mice and blocked PI3K/Akt signaling in kidney cells—no human data.
Luteolin Prevents Hyperoxaluria-Induced Renal Injury by Inhibiting Crystal Deposition and Renal Inflammation kidney stones animal study inflammation traditional chinese medicine
- Ginseng Compound Raises Testosterone — In Obese Mice2026-01-28
A ginseng-derived compound raised testicular testosterone in high-fat-diet mice by activating the cAMP/PKA/CREB pathway — no human data yet
Ginsenoside Rf Promotes Testosterone Synthesis Through the cAMP/PKA/CREB Signaling Pathway to Improve Obesity-Related Male Hypogonadism animal study hypogonadism testosterone obesity traditional chinese medicine
- Ancient TCM Formula Targets Copper-Mediated Sperm Death2025-12-13
A rat study found Zuogui Wan improved sperm quality partly by reducing testicular copper accumulation and suppressing cuproptosis
Research on the Mechanism of Zuogui Wan in Ameliorating Oligoasthenozoospermia in Rats via Modulating Cuproptosis-Related Pathways animal study male infertility spermatogenesis traditional chinese medicine oxidative stress
- Herbal Skin Patch Protects Rat Sperm from Plasticizer2025-11-28
In rats exposed to DEHP plasticizer, icariin microneedle patches reduced testicular damage and outperformed oral icariin — in rats
Transdermal Delivery of Icariin via Microneedle Patches Attenuates Phthalate-Induced Testicular Injury animal study male infertility traditional chinese medicine environmental exposure
- Chinese Herbal Mix Reverses Rat Infertility2025-10-31
TCM formula QYYJF improved sperm motility and HPG axis hormones in chemotherapy-damaged rats, via 25 identified serum compounds
Qingyu Yangjing Formula Ameliorates Cyclophosphamide-Induced Oligoasthenospermia by Regulating the Hypothalamic-Pituitary-Gonadal Axis and Inhibiting Testicular Oxidative Stress and Apoptosis in Rats traditional chinese medicine male infertility animal study semen quality
- TCM Formula Improves Sperm in Fat Mice2025-10-16
A traditional Chinese herbal formula reduced abnormal sperm and boosted concentration in obese mice — in mice only
Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1/p53 axis male infertility traditional chinese medicine animal study