← all papers · evidence quality (44) Science journalism, not medical advice.
- 1 in 5 Online Testosterone Clinics Invent Cardiovascular Benefits2026-05-19
253 testosterone clinic websites worldwide: 1 in 4 promote off-guideline treatments, 1 in 5 falsely claim cardiovascular benefits
Discordance Between Online Information and Male Hypogonadism Clinical Guidelines: A Global Multilingual Content Analysis hypogonadism testosterone therapy health services evidence quality
- Testosterone Therapy May Raise Fracture Risk2026-05-16
TRAVERSE trial found higher fracture rates in men randomized to testosterone — a result the review calls "unexpected"
Testosterone and Bone Health in Men testosterone testosterone therapy hypogonadism evidence quality
- Exercise Boosts Female Sexual Function—Evidence Weak2026-05-09
Exercise interventions produced a mean 5.31-point FSFI improvement vs. controls (15 studies), but evidence certainty is rated low.
Systematic Review and Meta-Analysis on the Beneficial Effect of Exercise on Sexual Dysfunction in Women sexual dysfunction systematic review meta-analysis women's health pelvic floor evidence quality
- Your Kidney Doctor Has No Idea You're Drinking That2026-05-07
~20% of kidney stone patients use cranberry extract or ACV; 87% believe them safe, almost none heard about them from a physician
Patient Perceptions of Dietary Supplement Use and Kidney Stone Disease kidney stones cross-sectional health services evidence quality
- Shockwave and PRP for ED? Still Experimental, Review Concludes2026-04-30
Narrative review synthesizes the full ED treatment ladder — prosthetics top 95% satisfaction; shockwave and PRP remain experimental.
Erectile Dysfunction: A Comprehensive Review of Pathophysiology, Diagnosis and Contemporary Management erectile dysfunction narrative review penile prosthesis sexual dysfunction evidence quality
- TCM Sperm Pill: 56 Animal Studies, 8 Human Trials2026-04-16
A PRISMA-screened evidence map finds mechanistic plausibility but only 8 clinical trials — most evidence is animal data
Multi-component, multi-target actions of Wuzi Yanzong Pill in male infertility: An evidence map linking clinical signals to mechanistic networks. male infertility traditional chinese medicine spermatogenesis oxidative stress evidence quality
- Sexual Medicine Has a Pleasure Problem2026-04-02
An editorial argues clinical sexual medicine neglects justice, rights, and pleasure — proposing a shift from fixing dysfunction to enabling well-being
Sexual Health Framing Sexual Medicine: Toward a More Humanistic Framework sexual dysfunction evidence quality women's health health services
- Web Therapy Helps ED—If Men Stick With It2026-04-02
21 studies found online CBT improved erectile function; ED remission rates were 20–30%, but fewer than 60% of participants stayed engaged
Internet-Based CBT and Online Counseling for Male Sexual Dysfunction: Systematic Review erectile dysfunction sexual dysfunction evidence quality
- Pharma Authors Write Fictional Stories, Call It Evidence2026-04-02
Two of four authors work for Viatris — a PDE5i manufacturer — yet COI is listed as "not listed"
Narrative-Based Sexual Medicine: Clinical Vignettes and PDE5 Inhibitor Management in Real-World ED erectile dysfunction evidence quality pharmacovigilance
- Your Antidepressant Has an 80% Sexual Side Effect Rate2026-04-01
Antidepressants cause sexual dysfunction in 25–80% of patients; antipsychotics in 16–60% — and most psychiatrists aren't asking
Psychiatric Disorders, Psychopharmacology and Sexual Dysfunction (ICSM 2024) antidepressants antipsychotics sexual dysfunction evidence quality
- Primary Care Penile Cancer Evidence: Coming Soon2026-03-30
A scoping review protocol — no findings yet — registering plans to map what evidence exists on these cancers in primary care
Strategies for Prevention, Early Detection and Management of Penile and Testicular Cancer in Primary Healthcare: Scoping Review Protocol penile cancer testicular cancer screening health services evidence quality
- Every Common Kidney Stone Fix Has Weak Evidence2026-03-24
31-study review finds "low" strength-of-evidence for nearly every kidney stone prevention strategy, and zero data on surveillance imaging
Prevention of Recurrent Nephrolithiasis in Adults and Children: A Systematic Review kidney stones systematic review evidence quality pediatric urology
- Female Sexual Dysfunction: Still Going Unasked2026-03-24
A PA-focused clinical review covering FSD classification, risk factors, and treatments — no original data, no reported effect sizes
Female Sexual Dysfunction: Screening, Diagnosis, and Management sexual dysfunction women's health evidence quality screening
- China's Math on Male HPV Vaccination Is Clear2026-03-20
Modeling 22 strategies, 20 cleared China's cost-effectiveness bar; vaccinating 14-year-olds with a 4-valent vaccine won
Economic Evaluation of 22 HPV Vaccination Strategies to Minimize the Risk of Penile, Anal, and Oropharyngeal Cancers in Chinese Males: A Markov Model Analysis penile cancer health services immunology evidence quality
- Male Fertility Prevention: Everything but the Numbers2026-03-18
Narrative review maps primary-to-tertiary prevention in male reproductive health — broad scope, no original data, no quantified effect sizes
Preventive Strategies and Biomarkers in Male Reproductive Health from Multidisciplinary Perspective: Narrative Review male infertility biomarkers infertility screening evidence quality
- New Kidney Stone Surgery Bleeds Less, Clears as Well2026-03-12
Meta-analysis of 3 RCTs (n=1,020) finds FANS-RIRS matches mini-PCNL for stone clearance but cuts hemorrhage risk by 92% and shortens hospital stay by 1.75 days
Efficacy and Safety of FANS-RIRS Versus Mini-PCNL for 2–3 cm Renal Stones: A Systematic Review and Meta-Analysis of RCTs kidney stones meta-analysis surgical outcomes evidence quality
- Kidney Stone Genes: Who Actually Needs Testing?2026-03-12
Review finds genetic testing pays off in high-risk cases, but polygenic risk scores remain unproven for most patients
Genetic Testing and Personalized Treatment for Kidney Stone Formers kidney stones genetics genomics evidence quality
- Four Guideline Panels, Four Different Playbooks2026-03-08
Four major urology societies agree on diagnosis basics but split on when to treat and what works—mostly because the evidence is thin.
Guideline of Guidelines: Peyronie's Disease Peyronie's disease evidence quality erectile dysfunction surgical outcomes
- Shockwave ED Stats Look Good. Patients Disagree.2026-03-07
LI-ESWT improved IIEF scores across 19 RCTs, but most studies failed to reach the minimally clinically important difference
A Close Look at the Evidence on Low-Intensity Shockwave Therapy in Erectile Dysfunction — A Systematic Review and Meta-Analysis of Randomized Controlled Trials erectile dysfunction meta-analysis evidence quality sexual dysfunction
- Most ED Evidence Is Garbage2026-03-06
95% of treatment evidence rated low or very low quality across 23 meta-analyses
Current treatment for erectile dysfunction: an umbrella review of systematic reviews and meta-analyses erectile dysfunction evidence quality meta-analysis
- Two IPP Brands, One Conflicted Reviewer2026-03-05
Narrative review declares both major IPP brands roughly equivalent — written by an author with industry ties to both manufacturers
Three-Piece Inflatable Penile Prosthesis Implantation in Clinical Practice penile prosthesis erectile dysfunction surgical outcomes evidence quality
- Stone Prevention: APPs In, Oversight Out2026-03-05
Survey of 69 urologists finds APPs handle stone prevention in ~half of U.S. practices, with half those practices reporting no formal physician oversight
Integrating Advanced Practice Providers in Kidney Stone Prevention: Patterns, Barriers, and Opportunities kidney stones health services evidence quality
- Shockwave Therapy for ED Fades After 12 Months2026-03-02
Li-ESWT pushed IIEF-EF from 11 to 21 at 12 months in 188 PDE5-refractory men — but scores slipped to 18 by 18 months
Low-Intensity Extracorporeal Shock Wave Therapy in Vasculogenic ED Refractory to PDE5 Inhibitors: A Prospective Study with 12- and 18-Month Outcomes erectile dysfunction vascular health evidence quality
- The Infertility Fallback Guide Ferring Helped Write2026-02-19
Industry-sponsored "expert opinion" recommends gonadotropins + hCG luteal support when pulsatile GnRH therapy is unavailable — no original data included
Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion. infertility women's health evidence quality hypogonadism
- AAS and ED: Most Reviews Nearly Worthless2026-02-12
Six systematic reviews on AAS-induced ED: four rated critically low confidence, one low, one medium
Erectile Dysfunction and Related Variables Due to Anabolic Steroid Use: A Review of Reviews erectile dysfunction hypogonadism systematic review evidence quality anabolic steroids
- Menopause Hurts Sex. Here's What Actually Helps.2026-02-04
A Stanford review surveys GSM treatments — hormonal, nonhormonal, and device-based — without reporting a single effect size
The New Toolbox for Reducing Painful Sex in Menopause sexual dysfunction women's health evidence quality menopause
- One in Four "Causative" IHH Variants: Actually Benign2026-01-30
When re-scored by ACMG standards, 26% of reported "causative" IHH/Kallmann variants were benign — and ClinVar confirmed only 18% as pathogenic
Overestimation of Pathogenic Variants in Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome genetics genomics hypogonadism evidence quality
- Men Think Average Is Small. Research Agrees They're Wrong.2026-01-20
Only 7 studies exist on this topic — all found men overestimate what's "normal" in size and sexual performance while underestimating their own normalcy
Are Men Aware of Normal Penile Length and Sexual Function? A Narrative Review narrative review sexual dysfunction erectile dysfunction evidence quality
- 67 Sperm Risk Factors, Almost All Weak Evidence2026-01-13
67 risk factors linked to male infertility catalogued — but 78% of the underlying evidence rated low or very low quality
Current Risk Factors for Male Infertility and Semen Parameters: An Umbrella Review of Systematic Reviews and Meta-Analyses male infertility semen quality evidence quality environmental exposure systematic review meta-analysis
- 39% of Women in Primary Care Have Sexual Dysfunction2026-01-06
39% prevalence of female sexual dysfunction in primary care — but the evidence base is five years stale
Female Sexual Dysfunction in Primary Care: A Systematic Review and Meta-Analysis of Prevalence sexual dysfunction meta-analysis evidence quality
- Antioxidants Out, Varicocele Repair In: WHO Rules2026
WHO's first unified infertility guideline backs varicocele repair conditionally but won't endorse antioxidants—evidence too heterogeneous
The WHO 2025 Guideline for the Prevention, Diagnosis and Treatment of Infertility: A Comprehensive Review with Focus on Male Reproductive Health male infertility infertility evidence quality semen quality
- Surgery for Micropenis: Evidence Too Thin to Recommend2026
Narrative review of 36 studies: early testosterone therapy beats surgery for micropenis, but RCT data barely exists
Micropenis in Children and Adolescents: A Narrative Review hypogonadism testosterone therapy evidence quality pediatric urology
- EAU Panel: Varicocele Surgery for Azoospermia? Evidence Too Weak2025-12-23
EAU guidelines panel finds the evidence for varicocele surgery in nonobstructive azoospermia too weak to support a strong recommendation
Varicocele Treatment in Azoospermia Before Artificial Reproductive Techniques: Critical Considerations by the EAU Guidelines Panel on Sexual and Reproductive Health varicocele male infertility evidence quality narrative review
- Labiaplasty Scores Better Sex on Paper2025-12-13
Pooled data from 6 studies show a moderate FSFI improvement (SMD 0.52) after labiaplasty, but low certainty undermines the finding
Sexual Function After Female Genital Cosmetic Surgery: A Systematic Review and Meta-Analysis meta-analysis surgical outcomes sexual dysfunction women's health evidence quality
- PET Scans Outperform CT for Penile Cancer Staging2025-11-29
Review finds FDG PET/CT beats conventional imaging for lymph node staging in penile cancer, though evidence base remains limited.
The Value of FDG PET/CT in Penile Cancer: An Update penile cancer biomarkers surgical outcomes evidence quality
- Penile Cancer Staging Overtreats 80% of Patients2025-11-20
Review argues current DSNB guidelines trigger full lymph node dissection in over 80% of men who wouldn't benefit from it
Sentinel Node Mapping in Penile Cancer: An Update on Methods and Pitfalls penile cancer surgical outcomes evidence quality biomarkers
- Three Guidelines on Penile Cancer Can't Agree2025-11-19
Three major oncology guideline bodies disagree on lymph node staging and treatment in penile cancer, leaving surgeons without consensus at every decision point.
Penile Cancer and Lymph Node Management: A Call for Standardization penile cancer surgical outcomes narrative review evidence quality
- Sildenafil Beats Tadalafil—But Read the Fine Print2025-11-19
Sildenafil scored higher than tadalafil on satisfaction and hardness in 132,100 real-world patients; vardenafil had the worst side-effect profile (47.4% vs ~34%).
Head-to-head Comparison of the Safety and Efficacy Profiles of Three Phosphodiesterase Type 5 Inhibitors through Patient-reported Outcomes of 130 000 Patients from a Direct-to-consumer Platform Database erectile dysfunction pharmacovigilance health services evidence quality
- Suction Scopes Look Promising, Evidence Still Thin2025-11-06
Systematic review of 35 studies finds suction-assisted ureteroscopy improves stone clearance and cuts infection risk, but high-quality evidence is scarce.
Complication Rates and Outcomes of Suction Devices in Ureteroscopy and Retrograde Intrarenal Surgery: A Systematic Review kidney stones evidence quality
- High-Volume Exercise Linked to Bladder Leaks in Men2025-10-21
Scoping review of 10 studies finds LUTS rates up to 18.8% in male athletes, with a strong dose-response correlation (R = 0.87) between weekly exercise volume and urinary symptoms.
Prevalence of Pelvic Floor Dysfunction in Male Athletes and Its Dose-Dependency in High-Intensity Exercise: A Scoping Review erectile dysfunction evidence quality cross-sectional pelvic floor
- One New Implant Fails 1 in 4 Times2025-09-13
Across 30 studies, penile implant removal rates were generally below 10%, but one newer device (Zephyr ZSI 475®) showed a 25.7% early mechanical failure rate.
Removal Rate and Mechanical Failure in Penile Prosthesis Implantation: A Systematic Review penile prosthesis erectile dysfunction surgical outcomes evidence quality
- Smaller Kidney Stone Scope, Same Results, Fewer Complications2025-08-29
UM-PCNL cleared stones as effectively as standard PCNL in 628 patients but with fewer complications and shorter hospital stays.
Comparative Efficacy and Safety of Ultra-Mini-Percutaneous Nephrolithotomy Versus Standard Percutaneous Nephrolithotomy for Renal Calculi: A Systematic Review and Meta-Analysis kidney stones meta-analysis evidence quality
- Stone Patients Rate Their Pain 7 Out of 102025-07-15
44 UK stone patients rated QoL impact at median 7/10; 82% would take prophylactic medication, but no prevention drug yet has high-quality evidence behind it.
Patients' priorities in kidney stone disease kidney stones evidence quality surgical outcomes cross-sectional
- Glans Removal Outcomes Look Good — If You Squint2025-04-15
14 studies, 327 procedures: 91% retained erectile function after glansectomy, but outcome reporting was too inconsistent to draw firm conclusions
Functional Outcomes of Glansectomy to Treat Localised Penile Cancer: A Systematic Review penile cancer surgical outcomes sexual dysfunction evidence quality