← all papers · inflammation (22) Science journalism, not medical advice.
- Five Cell Death Routes Killing Sperm2026-06-16
Narrative review maps five regulated cell death pathways — apoptosis, autophagy, pyroptosis, ferroptosis, efferocytosis — as drivers of spermatogenic failure
Targeting Programmed Cell Death in Male Infertility: Pathogenic Mechanisms and Therapeutic Strategies male infertility spermatogenesis autophagy oxidative stress narrative review inflammation
- Can Varicocele Inflammation Reach the Penis?2026-05-25
A narrative review proposes that varicocele-driven systemic inflammation may impair erectile function — but the clinical evidence is thin
Advances in Immune-Inflammatory Interactions Within the Testicular-Penile Microenvironment of Varicocele Patients varicocele erectile dysfunction inflammation narrative review oxidative stress spermatogenesis immunology male infertility
- Plastic in Every Kidney Stone Tested2026-05-19
Microplastics found in 100% of kidney stone samples tested, median 12.89 μg/g, with six distinct polymer types identified
Multimodal Detection of Microplastics in Human Kidney Stones and Multi-Omics Exploration of Renal Cell Metaflammation kidney stones environmental exposure oxidative stress inflammation
- Gut Bacteria May Hurt Sperm. The Evidence Is Thin.2026-05-16
A plausible gut-testis axis linking dysbiosis to poor sperm quality — authors themselves admit few human studies back it up
Gut Microbial Dysbiosis and Male Reproductive Health: Current Insights and Future Directions gut microbiome male infertility spermatogenesis narrative review testosterone inflammation
- Immune War in the Testis — Mostly Mouse Data2026-05-12
A review proposes that a shared immune-inflammatory cascade disrupts sperm production — then admits most evidence comes from animals, not men.
Immunological Mechanisms and Precision Stratification in Male Infertility immunology male infertility inflammation oxidative stress narrative review biomarkers spermatogenesis
- Semen Inflammation Signals Sperm DNA Damage — With Caveats2026-05-06
High sperm DNA fragmentation correlated with elevated NLRP3, caspase-1, IL-1β, and IL-18 — but the protein data came from only 5 men per group
Inflammasome-Related Markers and Long Non-Coding RNAs in Seminal Plasma: Associations with Sperm DNA Fragmentation and Male Infertility male infertility DNA fragmentation inflammation biomarkers epigenetics oxidative stress
- Viral Orchitis Treatments Still Largely Inadequate2026-05-05
This narrative review covers how viruses like HIV and mumps damage testicular function—and admits current treatments fall short
Viral Orchitis and Male Infertility: A Comprehensive Review of Pathogenic Mechanisms and Outcomes male infertility orchitis spermatogenesis inflammation narrative review immunology
- Genetics Breaks the Prostatitis-ED Link2026-04-17
Genetic analysis of FinnGen data found no causal link between prostatitis and ED in either direction (OR=1.132, P=.199)
No Causal Effect Between Prostatitis and Erectile Dysfunction: Insights from a 2-Sample Bidirectional Mendelian Randomization Study erectile dysfunction genetics inflammation genomics
- Testosterone-Tipped Nanoparticles Find the Testes in Mice2026-04-15
Nanoparticles carrying green tea extract (EGCG) and zinc reduced testicular inflammation and preserved sperm structure in a mouse orchitis model
Testosterone-Modified Liposomes Loaded with the Zn-Polyphenol Complex for Treatment of Male Infertility animal study male infertility inflammation oxidative stress spermatogenesis
- Four Blood Ratios, Kidney Stones, Mixed Signals2026-03-27
Four composite blood ratios tied to kidney stone prevalence in 27K Americans — but one of the four didn't hold up under scrutiny
Association Between Novel Indicators for Inflammation and Metabolism and Kidney Stones: A Cross-Sectional Analysis of NHANES 2007-2018 kidney stones inflammation biomarkers cross-sectional metabolic syndrome
- Sperm's Chemical Entourage Signals the Uterus2026-03-16
Review argues seminal cytokines don't just carry sperm — they actively shape uterine receptivity and embryo implantation
Seminal Fluid Cytokines in Reproductive Health and Fertility of Men male infertility immunology semen quality inflammation narrative review
- When Your Body Attacks Your Own Sperm2026-03-12
Editorial overview of a themed issue: blood-testis barrier, antisperm antibodies, seminal cytokines, and genital pathogens as fertility disruptors
Male Infertility and Immune Function immunology male infertility semen quality systematic review narrative review inflammation antisperm antibodies
- HPV Raises Antisperm Antibodies Tenfold2026-03-11
GU infections were linked to measurable sperm parameter declines, but pregnancy outcomes mostly held — HPV was the outlier, with a tenfold antisperm antibody spike
Impact of Male Genital Tract Infections on Semen Quality: A Systematic Review and Meta-Analysis male infertility semen quality systematic review meta-analysis HPV antisperm antibodies inflammation
- Gum Disease and Infertility: Mostly Speculation So Far2026-03-08
A narrative review argues gum disease may worsen fertility via inflammation, but admits the human data barely supports it
Infertility and Periodontitis: Are We Connecting the Right Dots? infertility male infertility inflammation oxidative stress narrative review
- Inflammation Scores Track With Lower Testosterone2026-02-18
In 7,576 men from NHANES, higher composite inflammation scores independently predicted lower total and free testosterone — but the age-stratified FT findings raise questions
Association Between Chronic Inflammation Status and Serum Testosterone and Free Testosterone in Adult Males cross-sectional testosterone hypogonadism biomarkers inflammation
- Plant Compound Cuts Kidney Crystals—In Mice Only2026-02-09
Luteolin reduced calcium oxalate crystal deposition in mice and blocked PI3K/Akt signaling in kidney cells—no human data.
Luteolin Prevents Hyperoxaluria-Induced Renal Injury by Inhibiting Crystal Deposition and Renal Inflammation kidney stones animal study inflammation traditional chinese medicine
- Your Partner's Bacteria Can Shift Your Sperm2026-01-27
Anaerobe-heavy seminal profiles correlate with higher sperm DNA fragmentation and lower motility; Lactobacillus-rich profiles align with better DNA integrity
Micromanagement: How the Male Reproductive Microbiome Shapes Male Fertility male infertility semen quality DNA fragmentation oxidative stress inflammation
- Childhood Obesity Shrinks Testicles Before Puberty Starts2026-01-27
Obese prepubertal boys had smaller testicular volume, shorter penis length, and lower testosterone than normal-weight peers in a 60-boy study.
Obesity Impairs Male Reproductive Development in Prepubertal Boys via Local Adipose Tissue Inflammation and the STAT3/CYP19A1 Pathway obesity male infertility testosterone pediatric urology inflammation animal study
- Better Sperm Quality, Still Not Pregnant2026-01-05
Treating seminal tract infections improves sperm parameters and reduces DNA fragmentation — but no evidence shows it increases conception rates
Infection and Inflammation of the Seminal Tract: A Review of Its Relationship to Male Fertility male infertility semen quality DNA fragmentation inflammation
- Blocking One Protein Protects Penile Vessels in Diabetic Rats2025-12-16
Rat study identifies a molecular pathway linking high blood sugar to penile endothelial aging — no human data yet
Inhibition of c-Jun/Bak Signaling Alleviates Endothelial Cell Senescence and Inflammation Caused by Mitochondrial Dysfunction in DMED erectile dysfunction animal study oxidative stress vascular health inflammation
- Herbal Capsule Tackles BPH and ED Together in Rats2025-05-27
A Chinese herbal capsule eased both prostate enlargement and erectile dysfunction in rats—finasteride only fixed one
Intervention of Bazi Bushen Capsule on Benign Prostatic Hyperplasia Concomitant with Erectile Dysfunction Induced by Testosterone Supplementation in Spontaneously Hypertensive Rats BPH erectile dysfunction traditional chinese medicine animal study inflammation
- Massive Genital Swelling: No Protocol Exists2024-12-04
No evidence-based treatment protocol exists for penoscrotal elephantiasis, a rare lymphatic condition causing irreversible penile and scrotal swelling
Operative Management of Penoscrotal Elephantiasis narrative review surgical outcomes inflammation pathology